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ONTOLOGY REPORT - ANNOTATIONS


Term:plasma cell differentiation
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Accession:GO:0002317 term browser browse the term
Definition:The process in which a B cell acquires the specialized features of a plasma cell. A plasma cell is a lymphocyte which develops from a B cell and produces high amounts of antibody.
Comment:Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
Synonyms:related_synonym: plasma cell development


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plasma cell differentiation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Itm2a integral membrane protein 2A ISO (MGI:MGI:5613782|PMID:24831988) MGI PMID:24831988 MGI:MGI:5613782 NCBI chrNW_004955557:2,235,223...2,243,911
Ensembl chrNW_004955557:2,235,223...2,243,927
JBrowse link
G Lgals1 galectin 1 ISO (MGI:MGI:5301217|PMID:21753146) MGI PMID:21753146 MGI:MGI:5301217 NCBI chrNW_004955413:24,072,086...24,075,452
Ensembl chrNW_004955413:24,072,086...24,075,452
JBrowse link
G Lgals8 galectin 8 ISO (MGI:MGI:5301217|PMID:21753146) MGI PMID:21753146 MGI:MGI:5301217 NCBI chrNW_004955492:3,673,233...3,693,777
Ensembl chrNW_004955492:3,673,233...3,693,776
JBrowse link
G Nkx2-3 NK2 homeobox 3 ISO (MGI:MGI:1888604|PMID:10926756) MGI PMID:10926756 MGI:MGI:1888604 NCBI chrNW_004955507:5,454,871...5,457,247
Ensembl chrNW_004955507:5,455,087...5,457,660
JBrowse link
positive regulation of plasma cell differentiation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Il10 interleukin 10 ISO (PMID:22962438) ARUK-UCL PMID:22962438 NCBI chrNW_004955406:42,307,789...42,312,255
Ensembl chrNW_004955406:42,307,664...42,312,779
JBrowse link
G Il2 interleukin 2 ISO (PMID:22962438) ARUK-UCL PMID:22962438 NCBI chrNW_004955428:18,163,010...18,168,157
Ensembl chrNW_004955428:18,162,467...18,168,265
JBrowse link
G Xbp1 X-box binding protein 1 ISO (PMID:11460154) UniProtKB PMID:11460154 NCBI chrNW_004955455:3,037,885...3,041,827 JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 11889
    immune system process 1907
      leukocyte activation 799
        leukocyte activation involved in immune response 243
          lymphocyte activation involved in immune response 170
            B cell activation involved in immune response 83
              mature B cell differentiation involved in immune response 25
                plasma cell differentiation 7
                  negative regulation of plasma cell differentiation 0
                  positive regulation of plasma cell differentiation 3
                  regulation of plasma cell differentiation + 3
Path 2
Term Annotations click to browse term
  biological_process 11889
    developmental process 5616
      anatomical structure development 5254
        multicellular organism development 4812
          system development 4532
            animal organ development 3492
              hematopoietic or lymphoid organ development 867
                hemopoiesis 821
                  leukocyte differentiation 518
                    lymphocyte differentiation 351
                      B cell differentiation 117
                        mature B cell differentiation 32
                          mature B cell differentiation involved in immune response 25
                            plasma cell differentiation 7
                              negative regulation of plasma cell differentiation 0
                              positive regulation of plasma cell differentiation 3
                              regulation of plasma cell differentiation + 3
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.