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ONTOLOGY REPORT - ANNOTATIONS


Term:plasma cell differentiation
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Accession:GO:0002317 term browser browse the term
Definition:The process in which a B cell acquires the specialized features of a plasma cell. A plasma cell is a lymphocyte which develops from a B cell and produces high amounts of antibody.
Comment:Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
Synonyms:related_synonym: plasma cell development


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plasma cell differentiation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G LGALS1 galectin 1 ISO (MGI:MGI:5301217|PMID:21753146) MGI PMID:21753146 MGI:MGI:5301217 NCBI chr10:26,932,351...26,935,580
Ensembl chr10:26,932,301...26,935,646
JBrowse link
G LGALS8 galectin 8 ISO (MGI:MGI:5301217|PMID:21753146) MGI PMID:21753146 MGI:MGI:5301217 NCBI chr 4:3,548,066...3,581,382
Ensembl chr 4:3,533,200...3,567,311
JBrowse link
G NKX2-3 NK2 homeobox 3 IEA Ensembl GO_REF:0000107 NCBI chr28:12,466,319...12,469,467
Ensembl chr28:12,466,368...12,469,473
JBrowse link
negative regulation of plasma cell differentiation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CR1L complement C3b/C4b receptor 1 like ISO (PMID:22962438) ARUK-UCL PMID:22962438 NCBI chr 7:6,484,281...6,549,677 JBrowse link
positive regulation of plasma cell differentiation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G IL10 interleukin 10 ISO (PMID:22962438) ARUK-UCL PMID:22962438 NCBI chr 7:5,933,285...5,937,057
Ensembl chr 7:5,933,285...5,937,057
JBrowse link
G IL2 interleukin 2 ISO (PMID:22962438) ARUK-UCL PMID:22962438 NCBI chr19:17,750,780...17,756,394
Ensembl chr19:17,750,780...17,756,394
JBrowse link
G XBP1 X-box binding protein 1 ISO (PMID:11460154) UniProtKB PMID:11460154 NCBI chr26:22,162,675...22,168,149 JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 16187
    immune system process 2291
      leukocyte activation 886
        leukocyte activation involved in immune response 272
          lymphocyte activation involved in immune response 190
            B cell activation involved in immune response 88
              mature B cell differentiation involved in immune response 25
                plasma cell differentiation 7
                  negative regulation of plasma cell differentiation 1
                  positive regulation of plasma cell differentiation 3
                  regulation of plasma cell differentiation + 4
Path 2
Term Annotations click to browse term
  biological_process 16187
    developmental process 6309
      anatomical structure development 5857
        multicellular organism development 5350
          system development 4984
            animal organ development 3823
              hematopoietic or lymphoid organ development 962
                hemopoiesis 915
                  leukocyte differentiation 576
                    lymphocyte differentiation 390
                      B cell differentiation 136
                        mature B cell differentiation 32
                          mature B cell differentiation involved in immune response 25
                            plasma cell differentiation 7
                              negative regulation of plasma cell differentiation 1
                              positive regulation of plasma cell differentiation 3
                              regulation of plasma cell differentiation + 4
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.