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ONTOLOGY REPORT - ANNOTATIONS


Term:plasma cell differentiation
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Accession:GO:0002317 term browser browse the term
Definition:The process in which a B cell acquires the specialized features of a plasma cell. A plasma cell is a lymphocyte which develops from a B cell and produces high amounts of antibody.
Comment:Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
Synonyms:related_synonym: plasma cell development


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plasma cell differentiation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ITM2A integral membrane protein 2A IEA Ensembl GO_REF:0000107 NCBI chr  X:79,360,384...79,367,334
Ensembl chr  X:79,360,384...79,367,667
JBrowse link
G LGALS1 galectin 1 IEA Ensembl GO_REF:0000107 NCBI chr22:37,675,636...37,679,802
Ensembl chr22:37,675,636...37,679,802
JBrowse link
G LGALS8 galectin 8 ISO (MGI:MGI:5301217|PMID:21753146) MGI PMID:21753146 MGI:MGI:5301217 NCBI chr 1:236,518,214...236,552,981
Ensembl chr 1:236,518,000...236,552,981
JBrowse link
G NKX2-3 NK2 homeobox 3 IEA Ensembl GO_REF:0000107 NCBI chr10:99,532,942...99,536,524
Ensembl chr10:99,532,942...99,536,524
JBrowse link
negative regulation of plasma cell differentiation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CR1 complement C3b/C4b receptor 1 (Knops blood group) IDA (PMID:22962438) ARUK-UCL PMID:22962438 NCBI chr 1:207,496,157...207,641,765
Ensembl chr 1:207,496,147...207,641,765
JBrowse link
positive regulation of plasma cell differentiation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G IL10 interleukin 10 IGI (PMID:22962438) ARUK-UCL PMID:22962438 NCBI chr 1:206,767,602...206,772,494
Ensembl chr 1:206,767,602...206,774,541
JBrowse link
G IL2 interleukin 2 IGI (PMID:22962438) ARUK-UCL PMID:22962438 NCBI chr 4:122,451,470...122,456,725
Ensembl chr 4:122,451,470...122,456,725
JBrowse link
G XBP1 X-box binding protein 1 IDA (PMID:11460154) UniProtKB PMID:11460154 NCBI chr22:28,794,560...28,800,569
Ensembl chr22:28,794,555...28,800,597
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 18670
    immune system process 3584
      leukocyte activation 1476
        leukocyte activation involved in immune response 756
          lymphocyte activation involved in immune response 209
            B cell activation involved in immune response 90
              mature B cell differentiation involved in immune response 27
                plasma cell differentiation 8
                  negative regulation of plasma cell differentiation 1
                  positive regulation of plasma cell differentiation 3
                  regulation of plasma cell differentiation + 4
Path 2
Term Annotations click to browse term
  biological_process 18670
    developmental process 7464
      anatomical structure development 6871
        multicellular organism development 6344
          system development 5748
            animal organ development 4414
              hematopoietic or lymphoid organ development 1152
                hemopoiesis 1104
                  leukocyte differentiation 635
                    lymphocyte differentiation 433
                      B cell differentiation 164
                        mature B cell differentiation 34
                          mature B cell differentiation involved in immune response 27
                            plasma cell differentiation 8
                              negative regulation of plasma cell differentiation 1
                              positive regulation of plasma cell differentiation 3
                              regulation of plasma cell differentiation + 4
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.