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ONTOLOGY REPORT - ANNOTATIONS


Term:plasma cell differentiation
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Accession:GO:0002317 term browser browse the term
Definition:The process in which a B cell acquires the specialized features of a plasma cell. A plasma cell is a lymphocyte which develops from a B cell and produces high amounts of antibody.
Comment:Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
Synonyms:related_synonym: plasma cell development


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plasma cell differentiation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Itm2a integral membrane protein 2A IMP (MGI:MGI:5613782|PMID:24831988) MGI PMID:24831988 MGI:MGI:5613782 NCBI chr  X:107,397,195...107,403,360
Ensembl chr  X:107,397,099...107,403,376
JBrowse link
G Lgals1 lectin, galactose binding, soluble 1 IDA (MGI:MGI:5301217|PMID:21753146) MGI PMID:21753146 MGI:MGI:5301217 NCBI chr15:78,926,725...78,930,465
Ensembl chr15:78,926,725...78,930,465
JBrowse link
G Lgals8 lectin, galactose binding, soluble 8 IDA (MGI:MGI:5301217|PMID:21753146) MGI PMID:21753146 MGI:MGI:5301217 NCBI chr13:12,439,402...12,464,977
Ensembl chr13:12,439,415...12,464,944
JBrowse link
G Nkx2-3 NK2 homeobox 3 IMP (MGI:MGI:1888604|PMID:10926756) MGI PMID:10926756 MGI:MGI:1888604 NCBI chr19:43,612,325...43,615,892
Ensembl chr19:43,612,325...43,615,892
JBrowse link
positive regulation of plasma cell differentiation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Il10 interleukin 10 ISO MGI GO_REF:0000096, MGI:MGI:4834177 NCBI chr 1:131,019,845...131,024,970
Ensembl chr 1:131,019,845...131,024,974
JBrowse link
G Il2 interleukin 2 ISO MGI GO_REF:0000096, MGI:MGI:4834177 NCBI chr 3:37,120,713...37,125,954
Ensembl chr 3:37,120,523...37,125,959
JBrowse link
G Xbp1 X-box binding protein 1 ISO MGI GO_REF:0000096, MGI:MGI:4834177 NCBI chr11:5,520,641...5,525,993
Ensembl chr11:5,520,659...5,525,893
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 23392
    immune system process 2928
      leukocyte activation 1085
        leukocyte activation involved in immune response 304
          lymphocyte activation involved in immune response 213
            B cell activation involved in immune response 91
              mature B cell differentiation involved in immune response 26
                plasma cell differentiation 7
                  negative regulation of plasma cell differentiation 0
                  positive regulation of plasma cell differentiation 3
                  regulation of plasma cell differentiation + 3
Path 2
Term Annotations click to browse term
  biological_process 23392
    developmental process 7030
      anatomical structure development 6504
        multicellular organism development 5967
          system development 5379
            animal organ development 4136
              hematopoietic or lymphoid organ development 1055
                hemopoiesis 1005
                  leukocyte differentiation 627
                    lymphocyte differentiation 429
                      B cell differentiation 160
                        mature B cell differentiation 33
                          mature B cell differentiation involved in immune response 26
                            plasma cell differentiation 7
                              negative regulation of plasma cell differentiation 0
                              positive regulation of plasma cell differentiation 3
                              regulation of plasma cell differentiation + 3
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.