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ONTOLOGY REPORT - ANNOTATIONS


Term:plasma cell differentiation
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Accession:GO:0002317 term browser browse the term
Definition:The process in which a B cell acquires the specialized features of a plasma cell. A plasma cell is a lymphocyte which develops from a B cell and produces high amounts of antibody.
Comment:Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
Synonyms:related_synonym: plasma cell development


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plasma cell differentiation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ITM2A integral membrane protein 2A IEA Ensembl GO_REF:0000107 NCBI chr  X:63,430,020...63,437,027
Ensembl chr  X:63,430,021...63,437,032
JBrowse link
G LGALS1 galectin 1 ISO (MGI:MGI:5301217|PMID:21753146) MGI PMID:21753146 MGI:MGI:5301217 NCBI chr 5:10,149,069...10,152,514
Ensembl chr 5:10,149,062...10,156,210
JBrowse link
G LGALS8 galectin 8 ISO (MGI:MGI:5301217|PMID:21753146) MGI PMID:21753146 MGI:MGI:5301217 NCBI chr14:54,867,014...54,892,188
Ensembl chr14:54,867,017...54,892,049
JBrowse link
G NKX2-3 NK2 homeobox 3 IEA Ensembl GO_REF:0000107 NCBI chr14:110,720,384...110,724,002
Ensembl chr14:110,720,397...110,724,001
JBrowse link
negative regulation of plasma cell differentiation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CR1 complement C3b/C4b receptor 1 (Knops blood group) ISO (PMID:22962438) ARUK-UCL PMID:22962438 NCBI chr 9:68,025,673...68,132,162 JBrowse link
positive regulation of plasma cell differentiation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G IL10 interleukin 10 ISO (PMID:22962438) ARUK-UCL PMID:22962438 NCBI chr 9:67,400,727...67,405,941
Ensembl chr 9:67,400,727...67,405,711
JBrowse link
G IL2 interleukin 2 ISO (PMID:22962438) ARUK-UCL PMID:22962438 NCBI chr 8:101,640,938...101,645,683
Ensembl chr 8:101,640,944...101,645,609
JBrowse link
G XBP1 X-box binding protein 1 IEA Ensembl GO_REF:0000107 NCBI chr14:46,011,239...46,016,526
Ensembl chr14:46,008,377...46,017,036
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 16545
    immune system process 2303
      leukocyte activation 896
        leukocyte activation involved in immune response 281
          lymphocyte activation involved in immune response 199
            B cell activation involved in immune response 87
              mature B cell differentiation involved in immune response 25
                plasma cell differentiation 8
                  negative regulation of plasma cell differentiation 1
                  positive regulation of plasma cell differentiation 3
                  regulation of plasma cell differentiation + 4
Path 2
Term Annotations click to browse term
  biological_process 16545
    developmental process 6302
      anatomical structure development 5842
        multicellular organism development 5340
          system development 4963
            animal organ development 3802
              hematopoietic or lymphoid organ development 967
                hemopoiesis 919
                  leukocyte differentiation 582
                    lymphocyte differentiation 401
                      B cell differentiation 147
                        mature B cell differentiation 32
                          mature B cell differentiation involved in immune response 25
                            plasma cell differentiation 8
                              negative regulation of plasma cell differentiation 1
                              positive regulation of plasma cell differentiation 3
                              regulation of plasma cell differentiation + 4
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.