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ONTOLOGY REPORT - ANNOTATIONS


Term:plasma cell differentiation
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Accession:GO:0002317 term browser browse the term
Definition:The process in which a B cell acquires the specialized features of a plasma cell. A plasma cell is a lymphocyte which develops from a B cell and produces high amounts of antibody.
Comment:Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
Synonyms:related_synonym: plasma cell development


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plasma cell differentiation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Itm2a integral membrane protein 2A ISO MGI:MGI:5645968 (MGI:MGI:5613782|PMID:24831988) RGD PMID:24831988 MGI:MGI:5613782 NCBI chr  X:78,490,872...78,496,814
Ensembl chr  X:78,490,866...78,496,847
JBrowse link
G Lgals1 galectin 1 ISO (MGI:MGI:5301217|PMID:21753146) RGD PMID:21753146 MGI:MGI:5301217 NCBI chr 7:120,153,184...120,156,290
Ensembl chr 7:120,153,184...120,156,289
JBrowse link
G Lgals8 galectin 8 ISO (MGI:MGI:5301217|PMID:21753146) RGD PMID:21753146 MGI:MGI:5301217 NCBI chr17:66,487,451...66,515,316
Ensembl chr17:66,487,457...66,511,870
JBrowse link
G Nkx2-3 NK2 homeobox 3 ISO MGI:MGI:2448069 (MGI:MGI:1888604|PMID:10926756) RGD PMID:10926756 MGI:MGI:1888604 NCBI chr 1:263,361,238...263,371,043
Ensembl chr 1:263,367,266...263,370,219
JBrowse link
positive regulation of plasma cell differentiation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Il10 interleukin 10 ISO UniProtKB:P60568 (PMID:22962438) RGD PMID:22962438 NCBI chr13:47,738,933...47,743,392
Ensembl chr13:47,739,526...47,743,392
JBrowse link
G Il2 interleukin 2 ISO UniProtKB:P22301 (PMID:22962438) RGD PMID:22962438 NCBI chr 2:123,847,150...123,851,854
Ensembl chr 2:123,847,150...123,851,854
JBrowse link
G Xbp1 X-box binding protein 1 ISO
ISS
(PMID:11460154)
GO_REF:0000024
RGD
UniProt
PMID:11460154 GO_REF:0000024 NCBI chr14:85,753,736...85,758,820
Ensembl chr14:85,753,760...85,758,145
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20028
    immune system process 2843
      leukocyte activation 1060
        leukocyte activation involved in immune response 294
          lymphocyte activation involved in immune response 200
            B cell activation involved in immune response 88
              mature B cell differentiation involved in immune response 25
                plasma cell differentiation 7
                  negative regulation of plasma cell differentiation 0
                  positive regulation of plasma cell differentiation 3
                  regulation of plasma cell differentiation + 3
Path 2
Term Annotations click to browse term
  biological_process 20028
    developmental process 6827
      anatomical structure development 6269
        multicellular organism development 5744
          system development 5280
            animal organ development 4035
              hematopoietic or lymphoid organ development 1009
                hemopoiesis 957
                  leukocyte differentiation 598
                    lymphocyte differentiation 410
                      B cell differentiation 148
                        mature B cell differentiation 32
                          mature B cell differentiation involved in immune response 25
                            plasma cell differentiation 7
                              negative regulation of plasma cell differentiation 0
                              positive regulation of plasma cell differentiation 3
                              regulation of plasma cell differentiation + 3
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.