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ONTOLOGY REPORT - ANNOTATIONS


Term:plasma cell differentiation
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Accession:GO:0002317 term browser browse the term
Definition:The process in which a B cell acquires the specialized features of a plasma cell. A plasma cell is a lymphocyte which develops from a B cell and produces high amounts of antibody.
Comment:Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
Synonyms:related_synonym: plasma cell development


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plasma cell differentiation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Itm2a integral membrane protein 2A ISO (MGI:MGI:5613782|PMID:24831988) MGI PMID:24831988 MGI:MGI:5613782 NCBI chrNW_004936547:1,260,705...1,267,443 JBrowse link
G Lgals1 galectin 1 ISO (MGI:MGI:5301217|PMID:21753146) MGI PMID:21753146 MGI:MGI:5301217 NCBI chrNW_004936492:3,407,704...3,411,197 JBrowse link
G Lgals8 galectin 8 ISO (MGI:MGI:5301217|PMID:21753146) MGI PMID:21753146 MGI:MGI:5301217 NCBI chrNW_004936484:16,357,433...16,374,675 JBrowse link
G Nkx2-3 NK2 homeobox 3 ISO (MGI:MGI:1888604|PMID:10926756) MGI PMID:10926756 MGI:MGI:1888604 NCBI chrNW_004936636:529,669...532,237 JBrowse link
negative regulation of plasma cell differentiation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cr1 complement C3b/C4b receptor 1 (Knops blood group) ISO (PMID:22962438) ARUK-UCL PMID:22962438 NCBI chrNW_004936557:5,185,831...5,284,999 JBrowse link
positive regulation of plasma cell differentiation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Il10 interleukin 10 ISO (PMID:22962438) ARUK-UCL PMID:22962438 NCBI chrNW_004936557:5,834,874...5,838,502 JBrowse link
G Il2 interleukin 2 ISO (PMID:22962438) ARUK-UCL PMID:22962438 NCBI chrNW_004936662:1,594,953...1,599,625 JBrowse link
G Xbp1 X-box binding protein 1 ISO (PMID:11460154) UniProtKB PMID:11460154 NCBI chrNW_004936657:2,891,171...2,895,409 JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 11998
    immune system process 1918
      leukocyte activation 789
        leukocyte activation involved in immune response 241
          lymphocyte activation involved in immune response 167
            B cell activation involved in immune response 82
              mature B cell differentiation involved in immune response 22
                plasma cell differentiation 8
                  negative regulation of plasma cell differentiation 1
                  positive regulation of plasma cell differentiation 3
                  regulation of plasma cell differentiation + 4
Path 2
Term Annotations click to browse term
  biological_process 11998
    developmental process 5648
      anatomical structure development 5286
        multicellular organism development 4845
          system development 4567
            animal organ development 3516
              hematopoietic or lymphoid organ development 873
                hemopoiesis 826
                  leukocyte differentiation 513
                    lymphocyte differentiation 343
                      B cell differentiation 111
                        mature B cell differentiation 29
                          mature B cell differentiation involved in immune response 22
                            plasma cell differentiation 8
                              negative regulation of plasma cell differentiation 1
                              positive regulation of plasma cell differentiation 3
                              regulation of plasma cell differentiation + 4
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.