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ONTOLOGY REPORT - ANNOTATIONS


Term:pre-B cell differentiation
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Accession:GO:0002329 term browser browse the term
Definition:The process in which a precursor cell type acquires the specialized features of a pre-B cell. Pre-B cells follow the pro-B cell stage of immature B cell differentiation and undergo rearrangement of heavy chain V, D, and J gene segments.
Comment:Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
Synonyms:exact_synonym: pre-B lymphocyte differentiation
 related_synonym: pre-B cell development


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pre-B cell differentiation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atp11c ATPase phospholipid transporting 11C ISO (MGI:5002406|PMID:21423173) RGD PMID:21423173 MGI:5002406 NCBI chr  X:143,340,712...143,525,588
Ensembl chr  X:143,346,252...143,453,612
JBrowse link
G Cd24 CD24 molecule ISO MGI:2179996 (MGI:2179980|PMID:9028339), (MGI:74794|PMID:7795661) RGD PMID:7795661, PMID:9028339 MGI:2179980, MGI:74794 NCBI chr20:48,335,540...48,340,847
Ensembl chr20:48,335,540...48,340,846
JBrowse link
G Foxp1 forkhead box P1 ISO MGI:3711150 (MGI:3662963|PMID:16819554) RGD PMID:16819554 MGI:3662963 NCBI chr 4:131,362,178...131,963,466
Ensembl chr 4:131,366,744...131,694,755
JBrowse link
G Lrrc8a leucine rich repeat containing 8 VRAC subunit A ISS GO_REF:0000024 UniProt GO_REF:0000024 NCBI chr 3:8,801,544...8,829,506
Ensembl chr 3:8,802,852...8,828,533
JBrowse link
G Mir17 microRNA 17 ISO MGI:2676844|MGI:2676872|MGI:3618743|MGI:3629917|MGI:3629918 (MGI:3789916|PMID:18329372) RGD PMID:18329372 MGI:3789916 NCBI chr15:100,179,879...100,179,962
Ensembl chr15:100,179,879...100,179,962
JBrowse link
G Mir18a microRNA 18a ISO MGI:2676872|MGI:3618743|MGI:3619065|MGI:3629917|MGI:3629918 (MGI:3789916|PMID:18329372) RGD PMID:18329372 MGI:3789916 NCBI chr15:100,180,015...100,180,110
Ensembl chr15:100,180,015...100,180,110
JBrowse link
G Mir19a microRNA 19a ISO MGI:2676844|MGI:2676872|MGI:3619065|MGI:3629917|MGI:3629918 (MGI:3789916|PMID:18329372) RGD PMID:18329372 MGI:3789916 NCBI chr15:100,180,162...100,180,243
Ensembl chr15:100,180,162...100,180,243
JBrowse link
G Mir19b1 microRNA 19b-1 ISO MGI:2676844|MGI:2676872|MGI:3618743|MGI:3619065|MGI:3629918 (MGI:3789916|PMID:18329372) RGD PMID:18329372 MGI:3789916 NCBI chr15:100,180,464...100,180,550
Ensembl chr15:100,180,464...100,180,550
JBrowse link
G Mir20a microRNA 20a ISO MGI:2676844|MGI:3618743|MGI:3619065|MGI:3629917|MGI:3629918 (MGI:3789916|PMID:18329372) RGD PMID:18329372 MGI:3789916 NCBI chr15:100,180,334...100,180,418
Ensembl chr15:100,180,334...100,180,418
JBrowse link
G Mir92a1 microRNA 92a-1 ISO MGI:2676844|MGI:2676872|MGI:3618743|MGI:3619065|MGI:3629917 (MGI:3789916|PMID:18329372) RGD PMID:18329372 MGI:3789916 NCBI chr15:100,180,586...100,180,663
Ensembl chr15:100,180,586...100,180,663
JBrowse link
pre-B cell allelic exclusion term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atm ATM serine/threonine kinase ISO (MGI:3848557|PMID:19448632) RGD PMID:19448632 MGI:3848557 NCBI chr 8:58,015,938...58,119,973
Ensembl chr 8:58,015,940...58,120,045
JBrowse link
G Rag1 recombination activating 1 IBA
ISO
PMID:21873635
(MGI:3848557|PMID:19448632)
RGD PMID:19448632, PMID:21873635 MGI:3848557, RGD:13792537 NCBI chr 3:91,206,394...91,217,491
Ensembl chr 3:91,206,394...91,217,491
JBrowse link
G Rag2 recombination activating 2 ISO (MGI:3848557|PMID:19448632) RGD PMID:19448632 MGI:3848557 NCBI chr 3:91,191,837...91,200,134
Ensembl chr 3:91,191,837...91,200,134
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20020
    immune system process 2840
      leukocyte activation 1058
        lymphocyte activation 874
          lymphocyte differentiation 410
            B cell differentiation 148
              immature B cell differentiation 19
                pre-B cell differentiation 13
                  pre-B cell allelic exclusion 3
                  pre-B cell receptor expression 0
Path 2
Term Annotations click to browse term
  biological_process 20020
    developmental process 6826
      anatomical structure development 6268
        multicellular organism development 5743
          system development 5279
            animal organ development 4033
              hematopoietic or lymphoid organ development 1009
                hemopoiesis 957
                  leukocyte differentiation 598
                    mononuclear cell differentiation 464
                      lymphocyte differentiation 410
                        B cell differentiation 148
                          immature B cell differentiation 19
                            pre-B cell differentiation 13
                              pre-B cell allelic exclusion 3
                              pre-B cell receptor expression 0
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.