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ONTOLOGY REPORT - ANNOTATIONS


Term:mature B cell differentiation
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Accession:GO:0002335 term browser browse the term
Definition:The process in which transitional stage B cells acquire the specialized features of mature B cells in the spleen.
Comment:Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
Synonyms:exact_synonym: mature B lymphocyte differentiation
 related_synonym: mature cell development


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mature B cell differentiation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pou2f2 POU class 2 homeobox 2 ISO MGI:MGI:3028896 (MGI:MGI:53043|PMID:8096198) RGD PMID:8096198 MGI:MGI:53043 NCBI chr 1:81,966,791...82,049,116
Ensembl chr 1:81,964,104...82,004,538
JBrowse link
B-1 B cell differentiation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd19 CD19 molecule ISO (MGI:MGI:74944|PMID:7543183) RGD PMID:7543183 MGI:MGI:74944 NCBI chr 1:197,815,422...197,822,123
Ensembl chr 1:197,815,413...197,821,936
JBrowse link
G Malt1 MALT1 paracaspase ISO MGI:MGI:3639305 (MGI:MGI:3629264|PMID:14614861) RGD PMID:14614861 MGI:MGI:3629264 NCBI chr18:61,108,712...61,162,446
Ensembl chr18:61,109,069...61,162,445
JBrowse link
B-1 B cell lineage commitment term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Slamf8 SLAM family member 8 ISO (MGI:MGI:6215454|PMID:11313408) RGD PMID:11313408 MGI:MGI:6215454 NCBI chr13:90,967,862...90,978,752
Ensembl chr13:90,967,739...90,977,734
JBrowse link
B-1a B cell differentiation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cmtm7 CKLF-like MARVEL transmembrane domain containing 7 ISO (MGI:MGI:5554324|PMID:24080084) RGD PMID:24080084 MGI:MGI:5554324 NCBI chr 8:122,814,563...122,841,479
Ensembl chr 8:122,812,459...122,841,477
JBrowse link
G Nfatc1 nuclear factor of activated T-cells 1 ISO MGI:MGI:2181762 (MGI:MGI:2680742|PMID:14595020) RGD PMID:14595020 MGI:MGI:2680742 NCBI chr18:77,203,517...77,322,690
Ensembl chr18:77,203,525...77,322,690
JBrowse link
G Plcl2 phospholipase C-like 2 ISO MGI:MGI:2679632 (MGI:MGI:2677607|PMID:14517301) RGD PMID:14517301 MGI:MGI:2677607 NCBI chr 9:1,782,536...1,984,654
Ensembl chr 9:1,782,536...1,984,654
JBrowse link
follicular B cell differentiation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Plcg2 phospholipase C, gamma 2 ISO
IEA
MGI:MGI:2386100 (MGI:MGI:2679743|PMID:12928432)
GO_REF:0000107
RGD
Ensembl
PMID:12928432 GO_REF:0000107, MGI:MGI:2679743 NCBI chr19:50,039,410...50,173,543
Ensembl chr19:50,045,020...50,173,220
JBrowse link
germinal center B cell differentiation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ada adenosine deaminase ISO MGI:MGI:1857117|MGI:MGI:2683027 (MGI:MGI:3619310|PMID:14607964) RGD PMID:14607964 MGI:MGI:3619310 NCBI chr 3:160,115,840...160,139,947
Ensembl chr 3:160,115,842...160,139,947
JBrowse link
G Cdh17 cadherin 17 ISO (MGI:MGI:3531365|PMID:15688343) RGD PMID:15688343 MGI:MGI:3531365 NCBI chr 5:25,354,187...25,443,675
Ensembl chr 5:25,391,115...25,443,718
JBrowse link
G Il21 interleukin 21 ISS
ISO
GO_REF:0000024
(MGI:MGI:5450752|PMID:23045607)
UniProt
RGD
PMID:23045607 GO_REF:0000024, MGI:MGI:5450752 NCBI chr 2:123,965,021...123,972,356
Ensembl chr 2:123,965,021...123,972,356
JBrowse link
G Il6 interleukin 6 ISS
ISO
GO_REF:0000024
(MGI:MGI:5450752|PMID:23045607)
UniProt
RGD
PMID:23045607 GO_REF:0000024, MGI:MGI:5450752 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Itfg2 integrin alpha FG-GAP repeat containing 2 ISO MGI:MGI:4235940 (MGI:MGI:5547463|PMID:23997217) RGD PMID:23997217 MGI:MGI:5547463 NCBI chr 4:161,730,643...161,744,281
Ensembl chr 4:161,730,641...161,743,896
JBrowse link
G Pou2af1 POU class 2 homeobox associating factor 1 ISO
IEA
(MGI:MGI:5450752|PMID:23045607)
GO_REF:0000107
RGD
Ensembl
PMID:23045607 GO_REF:0000107, MGI:MGI:5450752 NCBI chr 8:55,603,968...55,631,448
Ensembl chr 8:55,603,968...55,631,446
JBrowse link
marginal zone B cell differentiation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bcl3 BCL3, transcription coactivator ISO MGI:MGI:1861796 (MGI:MGI:85481|PMID:9009202) RGD PMID:9009202 MGI:MGI:85481 NCBI chr 1:80,730,758...80,745,273
Ensembl chr 1:80,730,499...80,744,831
JBrowse link
G Cdh17 cadherin 17 ISO (MGI:MGI:3531365|PMID:15688343) RGD PMID:15688343 MGI:MGI:3531365 NCBI chr 5:25,354,187...25,443,675
Ensembl chr 5:25,391,115...25,443,718
JBrowse link
G Dll1 delta like canonical Notch ligand 1 IEA
ISO
ISS
GO_REF:0000107
(MGI:MGI:3044313|PMID:15146182), (MGI:MGI:3838059|PMID:19217325)
GO_REF:0000024
Ensembl
RGD
UniProt
PMID:15146182, PMID:19217325 GO_REF:0000024, GO_REF:0000107, MGI:MGI:3044313, MGI:MGI:3838059 NCBI chr 1:57,318,621...57,326,732
Ensembl chr 1:57,318,708...57,327,379
JBrowse link
G Dock10 dedicator of cytokinesis 10 ISO (MGI:MGI:5818419|PMID:25729399) RGD PMID:25729399 MGI:MGI:5818419 NCBI chr 9:86,424,638...86,571,854
NCBI chr 9:86,312,470...86,423,054
Ensembl chr 9:86,312,501...86,571,870
JBrowse link
G Dock11 dedicator of cytokinesis 11 ISO (MGI:MGI:5818419|PMID:25729399) RGD PMID:25729399 MGI:MGI:5818419 NCBI chr  X:122,507,169...122,690,463
Ensembl chr  X:122,507,374...122,690,465
JBrowse link
G Lfng LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase ISO
ISS
(MGI:MGI:3838059|PMID:19217325)
GO_REF:0000024
RGD
UniProt
PMID:19217325 GO_REF:0000024, MGI:MGI:3838059 NCBI chr12:16,117,767...16,126,211
Ensembl chr12:16,118,634...16,126,953
JBrowse link
G Mfng MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase ISO (MGI:MGI:3838059|PMID:19217325) RGD PMID:19217325 MGI:MGI:3838059 NCBI chr 7:119,978,981...119,996,824
Ensembl chr 7:119,978,983...119,996,824
JBrowse link
G Notch2 notch receptor 2 ISO
IEA
ISS
(MGI:MGI:3838059|PMID:19217325)
GO_REF:0000107
GO_REF:0000024
RGD
Ensembl
UniProt
PMID:19217325 GO_REF:0000024, GO_REF:0000107, MGI:MGI:3838059 NCBI chr 2:200,187,184...200,320,403
Ensembl chr 2:200,187,179...200,320,215
JBrowse link
G Ptk2b protein tyrosine kinase 2 beta ISO
ISS
(MGI:MGI:1860716|PMID:10881171)
GO_REF:0000024
RGD
UniProt
PMID:10881171 GO_REF:0000024, MGI:MGI:1860716 NCBI chr15:42,827,306...42,947,796
Ensembl chr15:42,827,310...42,947,656
JBrowse link
mature B cell differentiation involved in immune response term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gpr183 G protein-coupled receptor 183 ISO (MGI:MGI:4352759|PMID:19597478) RGD PMID:19597478 MGI:MGI:4352759 NCBI chr15:108,364,701...108,376,221
Ensembl chr15:108,364,701...108,376,221
JBrowse link
G LOC688282 hypothetical protein LOC688282 ISO (MGI:MGI:6103709|PMID:28978694) RGD PMID:28978694 MGI:MGI:6103709 NCBI chr10:106,800,040...106,810,153
Ensembl chr10:106,800,142...106,809,239
JBrowse link
plasma cell differentiation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Itm2a integral membrane protein 2A ISO MGI:MGI:5645968 (MGI:MGI:5613782|PMID:24831988) RGD PMID:24831988 MGI:MGI:5613782 NCBI chr  X:78,490,872...78,496,814
Ensembl chr  X:78,490,866...78,496,847
JBrowse link
G Lgals1 galectin 1 ISO (MGI:MGI:5301217|PMID:21753146) RGD PMID:21753146 MGI:MGI:5301217 NCBI chr 7:120,153,184...120,156,290
Ensembl chr 7:120,153,184...120,156,289
JBrowse link
G Lgals8 galectin 8 ISO (MGI:MGI:5301217|PMID:21753146) RGD PMID:21753146 MGI:MGI:5301217 NCBI chr17:66,487,451...66,515,316
Ensembl chr17:66,487,457...66,511,870
JBrowse link
G Nkx2-3 NK2 homeobox 3 ISO MGI:MGI:2448069 (MGI:MGI:1888604|PMID:10926756) RGD PMID:10926756 MGI:MGI:1888604 NCBI chr 1:263,361,238...263,371,043
Ensembl chr 1:263,367,266...263,370,219
JBrowse link
positive regulation of plasma cell differentiation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Xbp1 X-box binding protein 1 ISO
ISS
(PMID:11460154)
GO_REF:0000024
RGD
UniProt
PMID:11460154 GO_REF:0000024 NCBI chr14:85,753,736...85,758,820
Ensembl chr14:85,753,760...85,758,145
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20017
    immune system process 2838
      leukocyte activation 1058
        lymphocyte activation 871
          lymphocyte differentiation 407
            B cell differentiation 145
              mature B cell differentiation 29
                B-1 B cell differentiation + 6
                mature B cell differentiation involved in immune response + 22
Path 2
Term Annotations click to browse term
  biological_process 20017
    developmental process 6813
      anatomical structure development 6256
        multicellular organism development 5735
          system development 5272
            immune system development 1073
              hematopoietic or lymphoid organ development 1008
                hemopoiesis 956
                  leukocyte differentiation 595
                    lymphocyte differentiation 407
                      B cell differentiation 145
                        mature B cell differentiation 29
                          B-1 B cell differentiation + 6
                          mature B cell differentiation involved in immune response + 22
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.