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ONTOLOGY REPORT - ANNOTATIONS


Term:B cell affinity maturation
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Accession:GO:0002344 term browser browse the term
Definition:The process in which B cells produce antibodies with increased antigen affinity. This is accomplished by somatic hypermutation and selection for B cells which produce higher affinity antibodies to antigen.
Synonyms:exact_synonym: B-lymphocyte affinity maturation


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B cell affinity maturation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Btk Bruton tyrosine kinase JBrowse link X 105,360,922 105,390,580 RGD:1624291
G RT1-Bb RT1 class II, locus Bb JBrowse link 20 4,043,726 4,049,367 RGD:1624291
RGD:1600115

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Term Annotations click to browse term
  biological_process 19678
    immune system process 2774
      B cell selection 4
        peripheral B cell selection 2
          B cell affinity maturation 2
            somatic hypermutation of immunoglobulin genes involved in immune response 0
Path 2
Term Annotations click to browse term
  biological_process 19678
    developmental process 6728
      anatomical structure development 6176
        multicellular organism development 5633
          system development 5209
            immune system development 1054
              hematopoietic or lymphoid organ development 991
                hemopoiesis 939
                  leukocyte differentiation 582
                    lymphocyte differentiation 398
                      B cell differentiation 143
                        B cell selection 4
                          peripheral B cell selection 2
                            B cell affinity maturation 2
                              somatic hypermutation of immunoglobulin genes involved in immune response 0
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.