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ONTOLOGY REPORT - ANNOTATIONS


Term:granuloma formation
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Accession:GO:0002432 term browser browse the term
Definition:The formation of nodular inflammatory lesions, usually small or granular, firm, persistent, well-structured, and containing compactly grouped T lymphocytes and modified phagocytes such as epithelioid cells, giant cells, and other macrophages. Granuloma formation represents a chronic inflammatory response initiated by various infectious and noninfectious agents. The center of a granuloma consists of fused macrophages, which can become necrotic.


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granuloma formation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cebpb CCAAT/enhancer binding protein beta ISO
ISS
(MGI:MGI:4360613|PMID:17911624)
GO_REF:0000024
RGD
UniProt
PMID:17911624 GO_REF:0000024, MGI:MGI:4360613 NCBI chr 3:164,424,502...164,425,933
Ensembl chr 3:164,424,515...164,425,910
JBrowse link
G Unc13d unc-13 homolog D ISO
IEA
MGI:MGI:3628822 (MGI:MGI:3703574|PMID:17420270)
GO_REF:0000107
RGD
Ensembl
PMID:17420270 GO_REF:0000107, MGI:MGI:3703574 NCBI chr10:104,613,907...104,628,664
Ensembl chr10:104,613,928...104,628,676
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20017
    immune system process 2838
      immune effector process 882
        granuloma formation 2
          negative regulation of granuloma formation 0
          positive regulation of granuloma formation 0
          regulation of granuloma formation + 0
Path 2
Term Annotations click to browse term
  biological_process 20017
    response to stimulus 10569
      response to stress 4060
        defense response 1686
          inflammatory response 732
            chronic inflammatory response 33
              granuloma formation 2
                negative regulation of granuloma formation 0
                positive regulation of granuloma formation 0
                regulation of granuloma formation + 0
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.