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ONTOLOGY REPORT - ANNOTATIONS


Term:type II hypersensitivity
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Accession:GO:0002445 term browser browse the term
Definition:An inflammatory response resulting in cell death or dysfunction mediated by activation of the classical complement pathway or induction of effector cell phagocytosis, cytolysis mechanisms via complement or Fc receptors following the binding of antibodies to cell surface antigens on a target cell, or mediated by the direct binding of antibody to cellular receptors.
Synonyms:xref: Wikipedia:Type_II_hypersensitivity


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negative regulation of antibody-dependent cellular cytotoxicity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G LOC100984838 low affinity immunoglobulin gamma Fc region receptor II-b JBrowse link 1 140,882,104 140,890,036 RGD:9068941
positive regulation of type IIa hypersensitivity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G C3 complement C3 JBrowse link 19 6,629,240 6,674,786 RGD:9068941
G FCER1G Fc fragment of IgE receptor Ig JBrowse link 1 140,539,555 140,543,545 RGD:9068941

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 15758
    immune system process 2763
      immune effector process 1108
        leukocyte mediated immunity 740
          myeloid leukocyte mediated immunity 525
            type II hypersensitivity 3
              negative regulation of type II hypersensitivity + 1
              positive regulation of type II hypersensitivity + 2
              regulation of type II hypersensitivity + 3
              type IIa hypersensitivity + 3
              type IIb hypersensitivity + 0
Path 2
Term Annotations click to browse term
  biological_process 15758
    response to stimulus 8304
      response to stress 3733
        defense response 1499
          inflammatory response 701
            inflammatory response to antigenic stimulus 56
              acute inflammatory response to antigenic stimulus 23
                hypersensitivity 9
                  type II hypersensitivity 3
                    negative regulation of type II hypersensitivity + 1
                    positive regulation of type II hypersensitivity + 2
                    regulation of type II hypersensitivity + 3
                    type IIa hypersensitivity + 3
                    type IIb hypersensitivity + 0
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.