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ONTOLOGY REPORT - ANNOTATIONS


Term:type II hypersensitivity
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Accession:GO:0002445 term browser browse the term
Definition:An inflammatory response resulting in cell death or dysfunction mediated by activation of the classical complement pathway or induction of effector cell phagocytosis, cytolysis mechanisms via complement or Fc receptors following the binding of antibodies to cell surface antigens on a target cell, or mediated by the direct binding of antibody to cellular receptors.
Synonyms:xref: Wikipedia:Type_II_hypersensitivity


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negative regulation of antibody-dependent cellular cytotoxicity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Fcgr2b Fc fragment of IgG receptor IIb JBrowse link NW_004955462 14,639,396 14,653,801 RGD:9068941
positive regulation of type IIa hypersensitivity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G C3 complement C3 JBrowse link NW_004955495 2,796,601 2,824,233 RGD:9068941
G Fcer1g Fc fragment of IgE receptor Ig JBrowse link NW_004955468 12,971,931 12,975,206 RGD:9068941

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 14616
    immune system process 2526
      immune effector process 1004
        leukocyte mediated immunity 666
          myeloid leukocyte mediated immunity 478
            type II hypersensitivity 3
              negative regulation of type II hypersensitivity + 1
              positive regulation of type II hypersensitivity + 2
              regulation of type II hypersensitivity + 3
              type IIa hypersensitivity + 3
              type IIb hypersensitivity + 0
Path 2
Term Annotations click to browse term
  biological_process 14616
    response to stimulus 7743
      response to stress 3505
        defense response 1323
          inflammatory response 646
            inflammatory response to antigenic stimulus 52
              acute inflammatory response to antigenic stimulus 22
                hypersensitivity 10
                  type II hypersensitivity 3
                    negative regulation of type II hypersensitivity + 1
                    positive regulation of type II hypersensitivity + 2
                    regulation of type II hypersensitivity + 3
                    type IIa hypersensitivity + 3
                    type IIb hypersensitivity + 0
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.