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ONTOLOGY REPORT - ANNOTATIONS


Term:type II hypersensitivity
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Accession:GO:0002445 term browser browse the term
Definition:An inflammatory response resulting in cell death or dysfunction mediated by activation of the classical complement pathway or induction of effector cell phagocytosis, cytolysis mechanisms via complement or Fc receptors following the binding of antibodies to cell surface antigens on a target cell, or mediated by the direct binding of antibody to cellular receptors.
Synonyms:xref: Wikipedia:Type_II_hypersensitivity


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antibody-dependent cellular cytotoxicity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G FCGR1A Fc fragment of IgG, high affinity Ia, receptor (CD64) JBrowse link 4 99,233,632 99,242,531 RGD:14298760
positive regulation of type IIa hypersensitivity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G C3 complement C3 JBrowse link 2 72,431,470 72,471,622 RGD:14298760
G FCGR1A Fc fragment of IgG, high affinity Ia, receptor (CD64) JBrowse link 4 99,233,632 99,242,531 RGD:14298760

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 15162
    immune system process 1627
      immune effector process 467
        leukocyte mediated immunity 223
          myeloid leukocyte mediated immunity 57
            type II hypersensitivity 2
              negative regulation of type II hypersensitivity + 0
              positive regulation of type II hypersensitivity + 2
              regulation of type II hypersensitivity + 2
              type IIa hypersensitivity + 2
              type IIb hypersensitivity + 0
Path 2
Term Annotations click to browse term
  biological_process 15162
    response to stimulus 7103
      response to stress 2450
        defense response 923
          inflammatory response 433
            inflammatory response to antigenic stimulus 36
              acute inflammatory response to antigenic stimulus 11
                hypersensitivity 6
                  type II hypersensitivity 2
                    negative regulation of type II hypersensitivity + 0
                    positive regulation of type II hypersensitivity + 2
                    regulation of type II hypersensitivity + 2
                    type IIa hypersensitivity + 2
                    type IIb hypersensitivity + 0
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.