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ONTOLOGY REPORT - ANNOTATIONS


Term:type II hypersensitivity
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Accession:GO:0002445 term browser browse the term
Definition:An inflammatory response resulting in cell death or dysfunction mediated by activation of the classical complement pathway or induction of effector cell phagocytosis, cytolysis mechanisms via complement or Fc receptors following the binding of antibodies to cell surface antigens on a target cell, or mediated by the direct binding of antibody to cellular receptors.
Synonyms:xref: Wikipedia:Type_II_hypersensitivity


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antibody-dependent cellular cytotoxicity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Fcgr1a Fc fragment of IgG receptor Ia JBrowse link 2 198,430,536 198,439,453 RGD:1624291
G Fcgr2a Fc fragment of IgG receptor IIa JBrowse link 13 91,146,878 91,163,691 RGD:1624291
G Ighg1 immunoglobulin heavy constant gamma 1 JBrowse link 6 139,140,572 139,784,388 RGD:1624291
positive regulation of antibody-dependent cellular cytotoxicity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G RT1-S3 RT1 class Ib, locus S3 JBrowse link 20 3,176,124 3,180,825 RGD:1624291
positive regulation of type IIa hypersensitivity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G C3 complement C3 JBrowse link 9 9,721,137 9,747,084 RGD:1624291
RGD:1600115
G Fcer1g Fc fragment of IgE receptor Ig JBrowse link 13 89,601,894 89,606,326 RGD:1624291
G Fcgr1a Fc fragment of IgG receptor Ia JBrowse link 2 198,430,536 198,439,453 RGD:1624291
G Fcgr2a Fc fragment of IgG receptor IIa JBrowse link 13 91,146,878 91,163,691 RGD:1624291
G Ighg1 immunoglobulin heavy constant gamma 1 JBrowse link 6 139,140,572 139,784,388 RGD:1624291
regulation of antibody-dependent cellular cytotoxicity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Fcgr2a Fc fragment of IgG receptor IIa JBrowse link 13 91,146,878 91,163,691 RGD:2293335

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19576
    immune system process 2692
      immune effector process 860
        leukocyte mediated immunity 501
          myeloid leukocyte mediated immunity 117
            type II hypersensitivity 6
              negative regulation of type II hypersensitivity + 0
              positive regulation of type II hypersensitivity + 6
              regulation of type II hypersensitivity + 6
              type IIa hypersensitivity + 6
              type IIb hypersensitivity + 0
Path 2
Term Annotations click to browse term
  biological_process 19576
    response to stimulus 10487
      response to stress 3959
        defense response 1592
          inflammatory response 715
            inflammatory response to antigenic stimulus 85
              acute inflammatory response to antigenic stimulus 36
                hypersensitivity 17
                  type II hypersensitivity 6
                    negative regulation of type II hypersensitivity + 0
                    positive regulation of type II hypersensitivity + 6
                    regulation of type II hypersensitivity + 6
                    type IIa hypersensitivity + 6
                    type IIb hypersensitivity + 0
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.