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ONTOLOGY REPORT - ANNOTATIONS


Term:humoral immune response mediated by circulating immunoglobulin
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Accession:GO:0002455 term browser browse the term
Definition:An immune response dependent upon secreted immunoglobulin. An example of this process is found in Mus musculus.
Synonyms:exact_synonym: circulating antibody mediated immune response;   circulating immunoglobulin mediated immune response;   humoral immune response mediated by circulating antibody
 related_synonym: humoral defence mechanism


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humoral immune response mediated by circulating immunoglobulin term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Bcl3 BCL3, transcription coactivator JBrowse link 1 80,730,758 80,745,273 RGD:1624291
G Cd81 Cd81 molecule JBrowse link 1 216,237,663 216,253,460 RGD:1600115
RGD:1624291
G Exo1 exonuclease 1 JBrowse link 13 93,936,989 93,962,749 RGD:1624291
G Ighg1 immunoglobulin heavy constant gamma 1 JBrowse link 6 139,140,572 139,784,388 RGD:1624291
G RT1-Bb RT1 class II, locus Bb JBrowse link 20 4,043,726 4,049,367 RGD:1624291
G RT1-Db1 RT1 class II, locus Db1 JBrowse link 20 4,087,621 4,097,190 RGD:1624291
G Zp2 zona pellucida glycoprotein 2 JBrowse link 1 189,899,906 189,911,650 RGD:1624291
G Zp3 zona pellucida glycoprotein 3 JBrowse link 12 23,735,225 23,752,734 RGD:1600115
RGD:1624291
complement activation, classical pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G AABR07034739.1 Ig lambda-2 chain C region RGD:13792537
G AABR07065640.1 RGD:13792537
G AABR07065643.1 RGD:13792537
G AABR07065645.1 RGD:13792537
G AABR07065645.2 RGD:13792537
G AABR07065651.2 RGD:13792537
G AABR07065651.3 RGD:13792537
G AABR07065651.4 RGD:13792537
G AABR07065651.5 RGD:13792537
G AABR07065651.6 RGD:13792537
G AABR07065651.7 RGD:13792537
G AABR07065651.8 RGD:13792537
G AABR07065656.1 RGD:13792537
G AABR07065656.10 RGD:13792537
G AABR07065656.2 RGD:13792537
G AABR07065656.3 RGD:13792537
G AABR07065656.4 RGD:13792537
G AABR07065656.5 RGD:13792537
G AABR07065656.6 RGD:13792537
G AABR07065656.7 RGD:13792537
G AABR07065656.9 RGD:13792537
G AABR07065673.1 RGD:13792537
G AABR07065676.1 RGD:13792537
G AABR07065680.1 RGD:13792537
G AABR07065688.1 RGD:13792537
G AABR07065693.1 RGD:13792537
G AABR07065693.2 RGD:13792537
G AABR07065693.3 RGD:13792537
G AABR07065699.2 RGD:13792537
G AABR07065699.3 RGD:13792537
G AABR07065699.4 RGD:13792537
G AABR07065699.5 RGD:13792537
G AABR07065705.4 RGD:13792537
G AABR07065705.5 RGD:13792537
G AABR07065705.6 RGD:13792537
G AABR07065714.1 RGD:13792537
G AABR07065737.1 RGD:13792537
G AABR07065740.1 RGD:13792537
G AABR07065750.1 RGD:13792537
G AABR07065750.2 RGD:13792537
G AABR07065753.1 RGD:13792537
G AABR07065768.1 RGD:13792537
G AABR07065768.2 RGD:13792537
G AABR07065768.3 RGD:13792537
G AABR07065772.1 RGD:13792537
G AABR07065772.2 RGD:13792537
G AABR07065772.4 RGD:13792537
G AABR07065773.1 RGD:13792537
G AABR07065774.1 RGD:13792537
G AABR07065776.2 RGD:13792537
G AABR07065778.1 RGD:13792537
G AABR07065778.2 RGD:13792537
G AABR07065778.3 RGD:13792537
G AABR07065782.1 RGD:13792537
G AABR07065789.1 RGD:13792537
G AABR07065789.2 RGD:13792537
G AABR07065789.3 RGD:13792537
G AABR07065790.1 RGD:13792537
G AABR07065792.1 RGD:13792537
G AABR07065792.2 RGD:13792537
G AABR07065798.1 RGD:13792537
G AABR07065802.1 RGD:13792537
G AABR07065804.1 RGD:13792537
G AABR07065808.1 RGD:13792537
G AABR07065811.1 RGD:13792537
G AABR07065812.1 RGD:13792537
G AABR07065812.2 RGD:13792537
G AABR07065813.1 RGD:13792537
G AABR07065814.1 RGD:13792537
G AABR07065814.2 RGD:13792537
G AABR07065814.3 RGD:13792537
G AABR07065814.4 RGD:13792537
G AABR07065814.5 RGD:13792537
G AABR07065814.7 RGD:13792537
G AABR07065815.1 RGD:13792537
G AABR07065815.2 RGD:13792537
G AABR07065821.1 RGD:13792537
G AABR07065823.2 RGD:13792537
G AABR07065823.3 RGD:13792537
G AABR07065827.1 RGD:13792537
G AABR07065834.1 RGD:13792537
G AABR07065837.1 RGD:13792537
G AABR07065839.1 RGD:13792537
G AABR07065844.1 RGD:13792537
G AABR07065883.1 RGD:13792537
G AABR07065886.1 RGD:13792537
G AABR07065889.1 RGD:13792537
G AC109737.1 RGD:13792537
G Apcs amyloid P component, serum JBrowse link 13 91,426,621 91,427,417 RGD:13792537
G C1qa complement C1q A chain JBrowse link 5 155,261,254 155,264,101 RGD:1624291
G C1qb complement C1q B chain JBrowse link 5 155,246,444 155,251,995 RGD:1600115
G C1qbp complement C1q binding protein JBrowse link 10 57,613,876 57,618,527 RGD:1600115
G C1qc complement C1q C chain JBrowse link 5 155,255,013 155,258,631 RGD:1600115
G C1r complement C1r JBrowse link 4 157,126,060 157,136,825 RGD:1600115
G C1rl complement C1r subcomponent like JBrowse link 4 157,108,190 157,122,689 RGD:1600115
G C1s complement C1s JBrowse link 4 157,143,592 157,155,592 RGD:1600115
G C2 complement C2 JBrowse link 20 4,542,340 4,561,152 RGD:1600115
G C3 complement C3 JBrowse link 9 9,721,137 9,747,084 RGD:1600605
G C4a complement C4A JBrowse link 20 2,651,599 2,678,183 RGD:1600115
G C4bpa complement component 4 binding protein, alpha JBrowse link 13 47,342,090 47,377,580 RGD:1600115
G C4bpb complement component 4 binding protein, beta JBrowse link 13 47,387,173 47,398,115 RGD:1600115
G C5 complement C5 JBrowse link 3
3
14,049,993
14,206,466
14,113,931
14,229,141
RGD:1600115
G C6 complement C6 JBrowse link 2 54,460,333 54,533,801 RGD:1600115
G C8b complement C8 beta chain JBrowse link 5 124,298,269 124,338,055 RGD:1600115
G C9 complement C9 JBrowse link 2 55,775,562 55,823,807 RGD:1600115
G Cfb complement factor B JBrowse link 20 4,536,206 4,542,073 RGD:1600115
G Cfi complement factor I JBrowse link 2 235,264,149 235,305,779 RGD:1600115
G Cr1l complement C3b/C4b receptor 1 like JBrowse link 13 113,824,886 113,872,097 RGD:1600115
G Crp C-reactive protein JBrowse link 13 91,080,448 91,081,358 RGD:1580273
RGD:13792537
G IgG-2a gamma-2a immunoglobulin heavy chain RGD:13792537
G Igh-6 immunoglobulin heavy chain 6 RGD:13792537
G Ighe immunoglobulin heavy constant epsilon JBrowse link 6 138,066,728 138,068,606 RGD:13792537
G Ighg1 immunoglobulin heavy constant gamma 1 JBrowse link 6 139,140,572 139,784,388 RGD:1624291
RGD:13792537
G Ighm immunoglobulin heavy constant mu RGD:13792537
G Igkc immunoglobulin kappa constant RGD:13792537
G Igll1 immunoglobulin lambda-like polypeptide 1 JBrowse link 11 88,388,378 88,391,524 RGD:13792537
G LOC100361706 lambda-chain C1-region-like JBrowse link 11 86,094,822 86,096,399 RGD:13792537
G LOC100911854 mannose-binding protein C-like JBrowse link 1 248,723,370 248,730,969 RGD:1600115
G LOC362795 immunoglobulin G heavy chain JBrowse link 6 138,192,156 138,201,560 RGD:13792537
G Masp2 mannan-binding lectin serine peptidase 2 JBrowse link 5 165,415,105 165,429,857 RGD:1600115
G Mbl1 mannose-binding lectin (protein A) 1 JBrowse link 16 18,736,154 18,742,193 RGD:1600115
G Mbl2 mannose binding lectin 2 JBrowse link 1 248,435,069 248,442,669 RGD:1600115
G Mptx1 mucosal pentraxin 1 JBrowse link 13 91,772,927 91,827,231 RGD:13792537
G RGD1564318 similar to immunoglobulin light chain variable region RGD:13792537
G Serping1 serpin family G member 1 JBrowse link 3 72,161,230 72,171,109 RGD:1600115
negative regulation of complement activation, classical pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G C4bpa complement component 4 binding protein, alpha JBrowse link 13 47,342,090 47,377,580 RGD:1624291
RGD:1600115
G C4bpb complement component 4 binding protein, beta JBrowse link 13 47,387,173 47,398,115 RGD:1624291
RGD:1600115
G Cd46 CD46 molecule JBrowse link 13 113,786,525 113,818,741 RGD:1624291
G Susd4 sushi domain containing 4 JBrowse link 13 101,181,932 101,307,912 RGD:1624291
negative regulation of humoral immune response mediated by circulating immunoglobulin term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Fcgr2b Fc fragment of IgG receptor IIb JBrowse link 13 89,329,298 89,343,916 RGD:1624291
G Foxj1 forkhead box J1 JBrowse link 10 105,282,090 105,289,396 RGD:1624291
G Ptpn6 protein tyrosine phosphatase, non-receptor type 6 JBrowse link 4 157,239,141 157,263,890 RGD:1624291
RGD:1600115
positive regulation of humoral immune response mediated by circulating immunoglobulin term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Fcer2 Fc fragment of IgE receptor II JBrowse link 12 2,233,772 2,245,324 RGD:1624291
G Gimap5 GTPase, IMAP family member 5 JBrowse link 4 78,377,228 78,386,683 RGD:2303774
G Hpx hemopexin JBrowse link 1 170,423,558 170,431,066 RGD:1624291
G Lta lymphotoxin alpha JBrowse link 20 4,851,889 4,854,677 RGD:1624291
G Nod2 nucleotide-binding oligomerization domain containing 2 JBrowse link 19 19,342,061 19,389,366 RGD:1624291
G Ptprc protein tyrosine phosphatase, receptor type, C JBrowse link 13 55,061,561 55,174,150 RGD:1624291
G Tnf tumor necrosis factor JBrowse link 20 5,189,382 5,192,000 RGD:1624291
regulation of complement activation, classical pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cd55 CD55 molecule (Cromer blood group) JBrowse link 13 47,125,156 47,153,557 RGD:1624291
regulation of humoral immune response mediated by circulating immunoglobulin term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ptprc protein tyrosine phosphatase, receptor type, C JBrowse link 13 55,061,561 55,174,150 RGD:1624291

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19439
    response to stimulus 10457
      immune response 1575
        humoral immune response 318
          humoral immune response mediated by circulating immunoglobulin 145
            complement activation, classical pathway + 128
            negative regulation of humoral immune response mediated by circulating immunoglobulin + 7
            positive regulation of humoral immune response mediated by circulating immunoglobulin + 7
            regulation of humoral immune response mediated by circulating immunoglobulin + 15
Path 2
Term Annotations click to browse term
  biological_process 19439
    immune system process 2631
      immune effector process 849
        leukocyte mediated immunity 492
          lymphocyte mediated immunity 395
            B cell mediated immunity 236
              immunoglobulin mediated immune response 232
                humoral immune response mediated by circulating immunoglobulin 145
                  complement activation, classical pathway + 128
                  negative regulation of humoral immune response mediated by circulating immunoglobulin + 7
                  positive regulation of humoral immune response mediated by circulating immunoglobulin + 7
                  regulation of humoral immune response mediated by circulating immunoglobulin + 15
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.