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ONTOLOGY REPORT - ANNOTATIONS


Term:germinal center formation
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Accession:GO:0002467 term browser browse the term
Definition:The process in which germinal centers form. A germinal center is a specialized microenvironment formed when activated B cells enter lymphoid follicles. Germinal centers are the foci for B cell proliferation and somatic hypermutation.


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germinal center formation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adam17 ADAM metallopeptidase domain 17 ISO (MGI:MGI:3828349|PMID:17371977) RGD PMID:17371977 MGI:MGI:3828349 NCBI chr 6:43,400,525...43,448,280
Ensembl chr 6:43,400,528...43,448,280
JBrowse link
G Bcl3 BCL3, transcription coactivator ISO MGI:MGI:1861796|MGI:MGI:2158443 (MGI:MGI:3655550|PMID:10586052), (MGI:MGI:85481|PMID:9009202), (MGI:MGI:87096|PMID:9133427) RGD PMID:9009202, PMID:9133427, PMID:10586052 MGI:MGI:3655550, MGI:MGI:85481, MGI:MGI:87096 NCBI chr 1:80,730,758...80,745,273
Ensembl chr 1:80,730,499...80,744,831
JBrowse link
G Bcl6 BCL6, transcription repressor ISO MGI:MGI:2158436|MGI:MGI:2158438|MGI:MGI:2158439 (MGI:MGI:1096098|PMID:9236196), (MGI:MGI:3654378|PMID:12354385), (MGI:MGI:87164|PMID:9110977), (MGI:MGI:892135|PMID:9171827) RGD PMID:9110977, PMID:9171827, PMID:9236196, PMID:12354385 MGI:MGI:1096098, MGI:MGI:3654378, MGI:MGI:87164, MGI:MGI:892135 NCBI chr11:80,255,790...80,279,075
Ensembl chr11:80,255,790...80,279,075
JBrowse link
G Klhl6 kelch-like family member 6 ISO (MGI:MGI:3603885|PMID:16166635) RGD PMID:16166635 MGI:MGI:3603885 NCBI chr11:84,745,958...84,785,315
Ensembl chr11:84,745,904...84,785,893
JBrowse link
G Mef2c myocyte enhancer factor 2C IEA
ISS
ISO
GO_REF:0000107
GO_REF:0000024
(MGI:MGI:3829850|PMID:18955699)
Ensembl
UniProt
RGD
PMID:18955699 GO_REF:0000024, GO_REF:0000107, MGI:MGI:3829850 NCBI chr 2:11,658,534...11,822,788
Ensembl chr 2:11,658,568...11,822,787
JBrowse link
G Nfkb2 nuclear factor kappa B subunit 2 ISO MGI:MGI:2179705 (MGI:MGI:3655550|PMID:10586052) RGD PMID:10586052 MGI:MGI:3655550 NCBI chr 1:266,050,634...266,059,277
Ensembl chr 1:266,053,002...266,059,256
JBrowse link
G Unc13d unc-13 homolog D ISO
IEA
MGI:MGI:3628822 (MGI:MGI:3703574|PMID:17420270)
GO_REF:0000107
RGD
Ensembl
PMID:17420270 GO_REF:0000107, MGI:MGI:3703574 NCBI chr10:104,613,907...104,628,664
Ensembl chr10:104,613,928...104,628,676
JBrowse link
negative regulation of germinal center formation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Foxj1 forkhead box J1 ISO (MGI:MGI:3589323|PMID:16002694) RGD PMID:16002694 MGI:MGI:3589323 NCBI chr10:105,282,090...105,289,396 JBrowse link
G Rc3h1 ring finger and CCCH-type domains 1 ISO (MGI:MGI:5284769|PMID:18172933) RGD PMID:18172933 MGI:MGI:5284769 NCBI chr13:78,723,028...78,794,663
Ensembl chr13:78,722,763...78,789,266
JBrowse link
positive regulation of germinal center formation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ada adenosine deaminase ISO MGI:MGI:1857117|MGI:MGI:2683027 (MGI:MGI:3619310|PMID:14607964) RGD PMID:14607964 MGI:MGI:3619310 NCBI chr 3:160,115,840...160,139,947
Ensembl chr 3:160,115,842...160,139,947
JBrowse link
G LOC100909593 class II histocompatibility antigen, M alpha chain-like ISO (MGI:MGI:2153656|PMID:11714799) RGD PMID:11714799 MGI:MGI:2153656 NCBI chr20:3,935,501...3,938,915 JBrowse link
G RT1-DMa RT1 class II, locus DMa ISO (MGI:MGI:2153656|PMID:11714799) RGD PMID:11714799 MGI:MGI:2153656 NCBI chr20:3,935,512...3,938,915
Ensembl chr20:5,240,975...5,244,386
JBrowse link
G Tnfrsf13c TNF receptor superfamily member 13C ISO MGI:MGI:2389403 (MGI:MGI:3036943|PMID:14557413) RGD PMID:14557413 MGI:MGI:3036943 NCBI chr 7:123,453,799...123,456,289
Ensembl chr 7:123,453,788...123,456,268
JBrowse link
G Tnfsf13 TNF superfamily member 13 ISO MGI:MGI:3038886 (MGI:MGI:3037416|PMID:14988498) RGD PMID:14988498 MGI:MGI:3037416 NCBI chr10:56,286,964...56,290,680
Ensembl chr10:56,286,887...56,289,952
JBrowse link
G Tnfsf13b TNF superfamily member 13b ISO MGI:MGI:2387426 (MGI:MGI:3036943|PMID:14557413) RGD PMID:14557413 MGI:MGI:3036943 NCBI chr16:85,275,690...85,306,419
Ensembl chr16:85,275,678...85,306,366
JBrowse link
regulation of germinal center formation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mef2c myocyte enhancer factor 2C IEA
ISS
ISO
GO_REF:0000107
GO_REF:0000024
(MGI:MGI:3795835|PMID:18438409)
Ensembl
UniProt
RGD
PMID:18438409 GO_REF:0000024, GO_REF:0000107, MGI:MGI:3795835 NCBI chr 2:11,658,534...11,822,788
Ensembl chr 2:11,658,568...11,822,787
JBrowse link
G Pkn1 protein kinase N1 ISO MGI:MGI:5475202 (MGI:MGI:5467878|PMID:23223530) RGD PMID:23223530 MGI:MGI:5467878 NCBI chr19:24,803,524...24,832,305
Ensembl chr19:24,803,524...24,831,500
JBrowse link
G Rc3h1 ring finger and CCCH-type domains 1 ISO (MGI:MGI:3580753|PMID:15917799), (MGI:MGI:3838060|PMID:19217324) RGD PMID:15917799, PMID:19217324 MGI:MGI:3580753, MGI:MGI:3838060 NCBI chr13:78,723,028...78,794,663
Ensembl chr13:78,722,763...78,789,266
JBrowse link
G Tnfaip3 TNF alpha induced protein 3 ISO (MGI:MGI:4946158|PMID:21088135) RGD PMID:21088135 MGI:MGI:4946158 NCBI chr 1:14,401,103...14,416,369
Ensembl chr 1:14,402,913...14,412,807
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20027
    developmental process 6827
      anatomical structure formation involved in morphogenesis 1213
        germinal center formation 17
          negative regulation of germinal center formation 2
          positive regulation of germinal center formation 6
          regulation of germinal center formation + 11
Path 2
Term Annotations click to browse term
  biological_process 20027
    immune system process 2844
      immune response 1755
        adaptive immune response 511
          adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains 417
            germinal center formation 17
              negative regulation of germinal center formation 2
              positive regulation of germinal center formation 6
              regulation of germinal center formation + 11
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.