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Term:Factor XII activation
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Accession:GO:0002542 term browser browse the term
Definition:Any process that activates Factor XII (Hageman factor). Factor XII is a protein synthesized by the liver that circulates in an inactive form until it encounters collagen or basement membrane or activated platelets (as occurs at the site of endothelial injury). Factor XII then undergoes a conformational change (becoming factor XIIa), exposing an active serine center that can subsequently cleave protein substrates and activate a variety of mediator systems. Factor XII is a participant in the clotting cascade as well as the kinin cascade.
Synonyms:exact_synonym: Hageman factor activation

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Factor XII activation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G F12 coagulation factor XII JBrowse link 17 9,736,577 9,744,420 RGD:1624291
G Kng2 kininogen 2 JBrowse link 11 81,509,185 81,516,759 RGD:11062094

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19317
    response to stimulus 10411
      protein activation cascade 13
        kinin cascade 3
          plasma kallikrein-kinin cascade 3
            Factor XII activation 2
Path 2
Term Annotations click to browse term
  biological_process 19317
    metabolic process 11540
      organic substance metabolic process 10932
        macromolecule metabolic process 9412
          protein metabolic process 5975
            cellular protein metabolic process 5303
              regulation of cellular protein metabolic process 2745
                positive regulation of cellular protein metabolic process 1660
                  positive regulation of proteolysis 364
                    positive regulation of protein processing 27
                      Factor XII activation 2
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.