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ONTOLOGY REPORT - ANNOTATIONS


Term:cytoplasmic pattern recognition receptor signaling pathway
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Accession:GO:0002753 term browser browse the term
Definition:Any series of molecular signals generated as a consequence of a cytoplasmic pattern recognition receptor (PRR) binding to one of its physiological ligands. PRRs bind pathogen-associated molecular pattern (PAMPs), structures conserved among microbial species.
Comment:Removed DAMP from the definition and synonyms, as this is a different process, see https://github.com/geneontology/go-ontology/issues/18588.
Synonyms:exact_synonym: cytoplasmic PAMP receptor signaling pathway;   cytoplasmic PRR signaling pathway;   cytoplasmic pathogen receptor signaling pathway;   cytoplasmic pattern recognition receptor signalling pathway


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cytoplasmic pattern recognition receptor signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Alpk1 alpha-kinase 1 JBrowse link 2 231,997,360 232,117,471 RGD:1624291
G Tifa TRAF-interacting protein with forkhead-associated domain JBrowse link 2 232,104,394 232,137,425 RGD:1600115
RGD:13792537
RGD:1624291
MDA-5 signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ifih1 interferon induced with helicase C domain 1 JBrowse link 3 48,557,696 48,604,097 RGD:1624291
negative regulation of MDA-5 signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G C1qbp complement C1q binding protein JBrowse link 10 57,613,876 57,618,527 RGD:1624291
RGD:1600115
G Dhx58 DEXH-box helicase 58 JBrowse link 10 88,599,722 88,611,562 RGD:1624291
G Riok3 RIO kinase 3 JBrowse link 18 3,565,166 3,590,739 RGD:1624291
G Tkfc triokinase and FMN cyclase JBrowse link 1 226,642,901 226,657,698 RGD:1624291
RGD:1600115
negative regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Tnfaip3 TNF alpha induced protein 3 JBrowse link 1 14,401,103 14,416,369 RGD:1624291
negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Erbin erbb2 interacting protein JBrowse link 2 33,880,860 33,952,806 RGD:1624291
G Ptpn22 protein tyrosine phosphatase, non-receptor type 22 JBrowse link 2 206,342,066 206,390,348 RGD:1624291
RGD:13792537
G Tnfaip3 TNF alpha induced protein 3 JBrowse link 1 14,401,103 14,416,369 RGD:1624291
negative regulation of RIG-I signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G C1qbp complement C1q binding protein JBrowse link 10 57,613,876 57,618,527 RGD:1624291
RGD:1600115
G Dhx58 DEXH-box helicase 58 JBrowse link 10 88,599,722 88,611,562 RGD:1624291
G Gpatch3 G patch domain containing 3 JBrowse link 5 151,796,456 151,806,007 RGD:1624291
RGD:13792537
G Nlrx1 NLR family member X1 JBrowse link 8 48,583,559 48,600,203 RGD:1624291
RGD:1600115
G Nploc4 NPL4 homolog, ubiquitin recognition factor JBrowse link 10 109,553,518 109,610,087 RGD:1600115
RGD:1624291
G Rnf125 ring finger protein 125 JBrowse link 18 15,193,226 15,225,454 RGD:1624291
G Sec14l1 SEC14-like lipid binding 1 JBrowse link 10 106,065,712 106,112,859 RGD:1624291
G Ufd1 ubiquitin recognition factor in ER associated degradation 1 JBrowse link 11 86,304,836 86,328,478 RGD:1624291
RGD:1600115
negative regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Tspan6 tetraspanin 6 JBrowse link X 104,719,930 104,729,606 RGD:1624291
nucleotide-binding oligomerization domain containing 1 signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Nfkbia NFKB inhibitor alpha JBrowse link 6 76,267,227 76,270,457 RGD:1624291
G Ripk2 receptor-interacting serine-threonine kinase 2 JBrowse link 5 29,838,713 29,870,390 RGD:1624291
nucleotide-binding oligomerization domain containing 2 signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Inava innate immunity activator JBrowse link 13 53,088,438 53,108,713 RGD:1624291
G Irgm immunity-related GTPase M JBrowse link 10 34,213,885 34,221,968 RGD:1624291
G Nfkbia NFKB inhibitor alpha JBrowse link 6 76,267,227 76,270,457 RGD:1624291
G Nod2 nucleotide-binding oligomerization domain containing 2 JBrowse link 19 19,342,061 19,389,366 RGD:1624291
G Otulin OTU deubiquitinase with linear linkage specificity JBrowse link 2 80,267,724 80,293,204 RGD:1624291
G Rela RELA proto-oncogene, NF-kB subunit JBrowse link 1 220,992,770 221,003,249 RGD:1624291
G Ripk2 receptor-interacting serine-threonine kinase 2 JBrowse link 5 29,838,713 29,870,390 RGD:1624291
positive regulation of MDA-5 signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G AABR07025140.1 RGD:1600115
G Ankrd17 ankyrin repeat domain 17 JBrowse link 14 19,291,025 19,431,521 RGD:1624291
G Dhx58 DEXH-box helicase 58 JBrowse link 10 88,599,722 88,611,562 RGD:1624291
G LOC100910107 ubiquitin carboxyl-terminal hydrolase DUB-1-like JBrowse link 1 169,720,247 169,721,788 RGD:1624291
positive regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Slc46a2 solute carrier family 46, member 2 JBrowse link 5 77,165,463 77,174,177 RGD:1624291
G Tlr4 toll-like receptor 4 JBrowse link 5 82,587,424 82,601,056 RGD:1624291
RGD:1600115
positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Hspa1a heat shock protein family A (Hsp70) member 1A JBrowse link 20 4,875,834 4,881,751 RGD:1624291
G Hspa1b heat shock protein family A (Hsp70) member 1B JBrowse link 20 4,877,638 4,880,112 RGD:1624291
G Peli3 pellino E3 ubiquitin protein ligase family member 3 JBrowse link 1 220,191,209 220,204,032 RGD:1624291
G Tlr4 toll-like receptor 4 JBrowse link 5 82,587,424 82,601,056 RGD:1624291
RGD:1600115
positive regulation of RIG-I signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G AABR07025140.1 RGD:1600115
G Ankrd17 ankyrin repeat domain 17 JBrowse link 14 19,291,025 19,431,521 RGD:1624291
G Dhx58 DEXH-box helicase 58 JBrowse link 10 88,599,722 88,611,562 RGD:1624291
G LOC100910107 ubiquitin carboxyl-terminal hydrolase DUB-1-like JBrowse link 1 169,720,247 169,721,788 RGD:1624291
G Pum1 pumilio RNA-binding family member 1 JBrowse link 5 148,781,239 148,911,776 RGD:1624291
G Pum2 pumilio RNA-binding family member 2 JBrowse link 6 33,786,184 33,865,693 RGD:1624291
G Trim15 tripartite motif containing 15 JBrowse link 20 2,194,293 2,203,636 RGD:1624291
G Usp15 ubiquitin specific peptidase 15 JBrowse link 7 66,595,707 66,687,707 RGD:1600115
RGD:1624291
G Zc3hav1 zinc finger CCCH-type containing, antiviral 1 JBrowse link 4 66,012,111 66,062,160 RGD:1624291
G Zcchc3 zinc finger CCHC-type containing 3 JBrowse link 3 147,877,321 147,881,434 RGD:1624291
regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Peli3 pellino E3 ubiquitin protein ligase family member 3 JBrowse link 1 220,191,209 220,204,032 RGD:1624291
regulation of RIG-I signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Nop53 NOP53 ribosome biogenesis factor JBrowse link 1 77,836,522 77,843,991 RGD:1624291
RIG-I signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ddx58 DEXD/H-box helicase 58 JBrowse link 5 56,486,584 56,536,898 RGD:1624291
G Lsm14a LSM14A mRNA processing body assembly factor JBrowse link 1 90,200,866 90,246,292 RGD:1624291
G Mavs mitochondrial antiviral signaling protein JBrowse link 3 123,776,147 123,790,572 RGD:1624291
G Rnf135 ring finger protein 135 JBrowse link 10 67,531,989 67,551,237 RGD:1600115
RGD:1624291
G Trim25 tripartite motif-containing 25 JBrowse link 10 76,343,847 76,362,159 RGD:1624291

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19336
    signaling 7456
      signal transduction 6872
        intracellular receptor signaling pathway 233
          cytoplasmic pattern recognition receptor signaling pathway 44
            cytoplasmic pattern recognition receptor signaling pathway in response to virus + 27
            nucleotide-binding oligomerization domain containing signaling pathway + 15
Path 2
Term Annotations click to browse term
  biological_process 19336
    biological regulation 13340
      regulation of biological process 12655
        regulation of cellular process 11994
          signal transduction 6872
            pattern recognition receptor signaling pathway 146
              cytoplasmic pattern recognition receptor signaling pathway 44
                cytoplasmic pattern recognition receptor signaling pathway in response to virus + 27
                nucleotide-binding oligomerization domain containing signaling pathway + 15
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.