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ONTOLOGY REPORT - ANNOTATIONS


Term:negative regulation of response to biotic stimulus
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Accession:GO:0002832 term browser browse the term
Definition:Any process that stops, prevents, or reduces the frequency, rate, or extent of a response to biotic stimulus.
Comment:Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
Synonyms:exact_synonym: down regulation of response to biotic stimulus;   downregulation of response to biotic stimulus
 narrow_synonym: inhibition of response to biotic stimulus


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negative regulation of antibacterial peptide production term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Spink5 serine peptidase inhibitor, Kazal type 5 JBrowse link 18 35,118,300 35,190,458 RGD:1624291
negative regulation of antifungal innate immune response term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Fam3a FAM3 metabolism regulating signaling molecule A JBrowse link X 156,319,687 156,328,974 RGD:1624291
negative regulation of complement activation, alternative pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cd46 CD46 molecule JBrowse link 13 113,786,525 113,818,741 RGD:1624291
G Susd4 sushi domain containing 4 JBrowse link 13 101,181,932 101,307,912 RGD:1624291
G Vsig4 V-set and immunoglobulin domain containing 4 JBrowse link X 65,370,851 65,400,298 RGD:1624291
RGD:13792537
negative regulation of complement activation, lectin pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G A2m alpha-2-macroglobulin JBrowse link 4 154,309,426 154,359,138 RGD:1624291
G Serping1 serpin family G member 1 JBrowse link 3 72,161,230 72,171,109 RGD:1624291
RGD:1600115
negative regulation of defense response to bacterium term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Arg2 arginase 2 JBrowse link 6 102,311,097 102,338,406 RGD:1600115
RGD:1624291
G Havcr2 hepatitis A virus cellular receptor 2 JBrowse link 10 31,561,838 31,590,624 RGD:1624291
G Mapkbp1 mitogen activated protein kinase binding protein 1 JBrowse link 3 111,767,126 111,817,103 RGD:1624291
G Sirt2 sirtuin 2 JBrowse link 1 86,948,866 86,971,954 RGD:1600115
RGD:1624291
negative regulation of defense response to virus term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G C1qbp complement C1q binding protein JBrowse link 10 57,613,876 57,618,527 RGD:1624291
RGD:1600115
G Fgl2 fibrinogen-like 2 JBrowse link 4 10,323,598 10,329,241 RGD:1624291
G Htra1 HtrA serine peptidase 1 JBrowse link 1 201,499,067 201,548,508 RGD:2311622
G Il2ra interleukin 2 receptor subunit alpha JBrowse link 17 70,500,672 70,547,929 RGD:2325989
G Itch itchy E3 ubiquitin protein ligase JBrowse link 3 150,660,665 150,752,016 RGD:1624291
G LOC294154 similar to chromosome 6 open reading frame 106 isoform a JBrowse link 20 7,331,321 7,397,588 RGD:1624291
G Pcbp2 poly(rC) binding protein 2 JBrowse link 7 144,077,901 144,103,723 RGD:1624291
G Ppm1b protein phosphatase, Mg2+/Mn2+ dependent, 1B JBrowse link 6 8,219,385 8,280,127 RGD:1624291
RGD:1600115
G Rnf26 ring finger protein 26 JBrowse link 8 48,447,113 48,449,311 RGD:1624291
G Traf3ip1 TRAF3 interacting protein 1 JBrowse link 9 98,621,499 98,658,223 RGD:1624291
RGD:1600115
G Trim38 tripartite motif containing 38 JBrowse link 17 43,600,006 43,607,879 RGD:1624291
negative regulation of defense response to virus by host term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Irf3 interferon regulatory factor 3 JBrowse link 1 100,992,244 100,997,202 RGD:1624291
G Micb MHC class I polypeptide-related sequence B JBrowse link 1 79,754,587 79,772,092 RGD:1624291
G Mul1 mitochondrial E3 ubiquitin protein ligase 1 JBrowse link 5 156,855,105 156,864,517 RGD:1624291
G Tarbp2 TARBP2 subunit of RISC loading complex JBrowse link 7 144,121,688 144,126,860 RGD:1624291
RGD:1600115
negative regulation of immune response to tumor cell term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Havcr2 hepatitis A virus cellular receptor 2 JBrowse link 10 31,561,838 31,590,624 RGD:1624291
negative regulation of innate immune response term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Acod1 aconitate decarboxylase 1 JBrowse link 15 93,612,968 93,622,322 RGD:1624291
G Ccr1 C-C motif chemokine receptor 1 JBrowse link 8 132,996,646 133,002,201 RGD:1624291
G Dhx58 DEXH-box helicase 58 JBrowse link 10 88,599,722 88,611,562 RGD:1624291
G Drd2 dopamine receptor D2 JBrowse link 8 53,678,777 53,743,643 RGD:1624291
G Grn granulin precursor JBrowse link 10 90,377,103 90,383,207 RGD:1600115
RGD:1624291
G Havcr2 hepatitis A virus cellular receptor 2 JBrowse link 10 31,561,838 31,590,624 RGD:1624291
G Irak3 interleukin-1 receptor-associated kinase 3 JBrowse link 7 64,922,830 64,982,224 RGD:1624291
G Mul1 mitochondrial E3 ubiquitin protein ligase 1 JBrowse link 5 156,855,105 156,864,517 RGD:1624291
G Nlrc3 NLR family, CARD domain containing 3 JBrowse link 10 11,809,531 11,844,184 RGD:1624291
G Nlrx1 NLR family member X1 JBrowse link 8 48,583,559 48,600,203 RGD:1624291
RGD:1600115
G Nmi N-myc (and STAT) interactor JBrowse link 3 37,458,891 37,480,984 RGD:1624291
G Tnfaip3 TNF alpha induced protein 3 JBrowse link 1 14,401,103 14,416,369 RGD:1624291
G Trafd1 TRAF type zinc finger domain containing 1 JBrowse link 12 40,695,520 40,709,438 RGD:1600115
RGD:1624291
G Tyro3 TYRO3 protein tyrosine kinase JBrowse link 3 111,597,102 111,616,142 RGD:1600115
RGD:1624291
negative regulation of interferon-gamma-mediated signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Arg1 arginase 1 JBrowse link 1 21,525,421 21,537,872 RGD:1624291
G Dnaja3 DnaJ heat shock protein family (Hsp40) member A3 JBrowse link 10 11,059,701 11,085,186 RGD:1624291
G Otop1 otopetrin 1 JBrowse link 14 77,236,278 77,263,729 RGD:1600115
RGD:1624291
G Parp14 poly (ADP-ribose) polymerase family, member 14 JBrowse link 11 68,105,442 68,137,509 RGD:1624291
G Pparg peroxisome proliferator-activated receptor gamma JBrowse link 4 147,274,055 147,399,383 RGD:1624291
G Ptpn2 protein tyrosine phosphatase, non-receptor type 2 JBrowse link 18 63,415,298 63,489,240 RGD:1624291
RGD:1600115
negative regulation of lipopolysaccharide-mediated signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cactin cactin, spliceosome C complex subunit JBrowse link 7 11,258,526 11,266,509 RGD:1624291
G Ltf lactotransferrin JBrowse link 8 119,290,416 119,313,261 RGD:1624291
G Nfkbil1 NFKB inhibitor like 1 JBrowse link 20 4,823,590 4,839,202 RGD:1624291
RGD:1600115
G Nlrp1b NLR family, pyrin domain containing 1B JBrowse link 10 57,755,957 57,847,867 RGD:1624291
G Prdm1 PR/SET domain 1 JBrowse link 20 49,464,921 49,556,623 RGD:1624291
G Prdx2 peroxiredoxin 2 JBrowse link 19 26,084,816 26,090,095 RGD:1624291
RGD:1600115
G Trib1 tribbles pseudokinase 1 JBrowse link 7 99,954,492 99,961,026 RGD:1624291
negative regulation of MDA-5 signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G C1qbp complement C1q binding protein JBrowse link 10 57,613,876 57,618,527 RGD:1624291
RGD:1600115
G Dhx58 DEXH-box helicase 58 JBrowse link 10 88,599,722 88,611,562 RGD:1624291
G Riok3 RIO kinase 3 JBrowse link 18 3,565,166 3,590,739 RGD:1624291
G Tkfc triokinase and FMN cyclase JBrowse link 1 226,642,901 226,657,698 RGD:1624291
RGD:1600115
negative regulation of natural killer cell cytokine production term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cd96 CD96 molecule JBrowse link 11 57,108,757 57,183,855 RGD:1624291
G RT1-CE5 RT1 class I, locus CE5 JBrowse link 20 4,892,702 4,896,993 RGD:1624291
negative regulation of natural killer cell degranulation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Lgals9 galectin 9 JBrowse link 10 64,737,022 64,760,195 RGD:1624291
G RT1-CE5 RT1 class I, locus CE5 JBrowse link 20 4,892,702 4,896,993 RGD:1624291
negative regulation of natural killer cell mediated cytotoxicity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Arrb2 arrestin, beta 2 JBrowse link 10 57,040,252 57,048,045 RGD:1624291
G Clec12b C-type lectin domain family 12, member B JBrowse link 4 163,140,883 163,157,996 RGD:1624291
G Crk CRK proto-oncogene, adaptor protein JBrowse link 10 63,829,731 63,855,999 RGD:11568650
G Gfer growth factor, augmenter of liver regeneration JBrowse link 10 14,059,347 14,061,703 RGD:9685777
G Igf2 insulin-like growth factor 2 JBrowse link 1 215,828,102 215,839,081 RGD:9685777
G Lgals9 galectin 9 JBrowse link 10 64,737,022 64,760,195 RGD:1624291
G Mill1 MHC I like leukocyte 1 JBrowse link 1 79,631,266 79,657,943 RGD:1624291
G RT1-A1 RT1 class Ia, locus A1 JBrowse link 20 5,414,463 5,418,012 RGD:2313500
G RT1-CE5 RT1 class I, locus CE5 JBrowse link 20 4,892,702 4,896,993 RGD:1624291
G RT1-S3 RT1 class Ib, locus S3 JBrowse link 20 3,176,124 3,180,825 RGD:1624291
G Sh2d1b2 SH2 domain containing 1B2 JBrowse link 13 88,557,361 88,584,078 RGD:1624291
negative regulation of natural killer cell mediated cytotoxicity directed against tumor cell target term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ceacam1 CEA cell adhesion molecule 1 JBrowse link 1 82,327,955 82,344,345 RGD:1624291
RGD:1600115
G Havcr2 hepatitis A virus cellular receptor 2 JBrowse link 10 31,561,838 31,590,624 RGD:1624291
G Klre1 killer cell lectin-like receptor, family E, member 1 JBrowse link 4 163,346,684 163,355,050 RGD:1299590
negative regulation of respiratory burst involved in inflammatory response term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Dusp10 dual specificity phosphatase 10 JBrowse link 13 104,284,660 104,321,455 RGD:1624291
G Grn granulin precursor JBrowse link 10 90,377,103 90,383,207 RGD:1600115
RGD:1624291
G Ins2 insulin 2 JBrowse link 1 215,856,967 215,858,034 RGD:1624291
G Rps19 ribosomal protein S19 JBrowse link 1 81,750,873 81,756,629 RGD:1624291
G Slamf8 SLAM family member 8 JBrowse link 13 90,967,862 90,978,752 RGD:1624291
negative regulation of RIG-I signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G C1qbp complement C1q binding protein JBrowse link 10 57,613,876 57,618,527 RGD:1624291
RGD:1600115
G Dhx58 DEXH-box helicase 58 JBrowse link 10 88,599,722 88,611,562 RGD:1624291
G Gpatch3 G patch domain containing 3 JBrowse link 5 151,796,456 151,806,007 RGD:1624291
RGD:13792537
G Nlrx1 NLR family member X1 JBrowse link 8 48,583,559 48,600,203 RGD:1624291
RGD:1600115
G Nploc4 NPL4 homolog, ubiquitin recognition factor JBrowse link 10 109,553,518 109,610,087 RGD:1600115
RGD:1624291
G Rnf125 ring finger protein 125 JBrowse link 18 15,193,226 15,225,454 RGD:1624291
G Sec14l1 SEC14-like lipid binding 1 JBrowse link 10 106,065,712 106,112,859 RGD:1624291
G Ufd1 ubiquitin recognition factor in ER associated degradation 1 JBrowse link 11 86,304,836 86,328,478 RGD:1624291
RGD:1600115
negative regulation of T cell mediated cytotoxicity directed against tumor cell target term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Muc4 mucin 4, cell surface associated JBrowse link 11 71,242,973 71,285,217 RGD:2303754
negative regulation of type I interferon-mediated signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Adar adenosine deaminase, RNA-specific JBrowse link 2 189,045,551 189,085,448 RGD:1624291
RGD:1600115
G Cactin cactin, spliceosome C complex subunit JBrowse link 7 11,258,526 11,266,509 RGD:1624291
G Cnot7 CCR4-NOT transcription complex, subunit 7 JBrowse link 16 54,899,452 54,918,616 RGD:1624291
G Dcst1 DC-STAMP domain containing 1 JBrowse link 2 188,672,549 188,690,004 RGD:1624291
G Mettl3 methyltransferase-like 3 JBrowse link 15 28,710,299 28,721,491 RGD:1624291
G Mmp12 matrix metallopeptidase 12 JBrowse link 8 5,594,717 5,616,494 RGD:1600115
RGD:1624291
G Mul1 mitochondrial E3 ubiquitin protein ligase 1 JBrowse link 5 156,855,105 156,864,517 RGD:1624291
G Nlrc5 NLR family, CARD domain containing 5 JBrowse link 19 10,904,381 11,006,202 RGD:1624291
RGD:13792537
G Ptpn2 protein tyrosine phosphatase, non-receptor type 2 JBrowse link 18 63,415,298 63,489,240 RGD:1624291
RGD:1600115
G Samhd1 SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1 JBrowse link 3 153,210,829 153,250,705 RGD:1624291
G Trex1 three prime repair exonuclease 1 JBrowse link 8 117,796,127 117,797,427 RGD:1624291
G Ttll12 tubulin tyrosine ligase like 12 JBrowse link 7 124,472,758 124,491,004 RGD:1624291
G Ythdf2 YTH N(6)-methyladenosine RNA binding protein 2 JBrowse link 5 150,364,490 150,390,173 RGD:1624291
G Ythdf3 YTH N(6)-methyladenosine RNA binding protein 3 JBrowse link 2 100,677,388 100,711,365 RGD:1624291
negative regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Tspan6 tetraspanin 6 JBrowse link X 104,719,930 104,729,606 RGD:1624291
protection from natural killer cell mediated cytotoxicity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Clec2d C-type lectin domain family 2, member D JBrowse link 4 162,278,252 162,302,881 RGD:1624291
G RT1-S3 RT1 class Ib, locus S3 JBrowse link 20 3,176,124 3,180,825 RGD:1624291
G Serpinb3a serine (or cysteine) peptidase inhibitor, clade B (ovalbumin), member 3A JBrowse link 13 27,153,500 27,159,319 RGD:1624291
G Serpinb9 serpin family B member 9 JBrowse link 17 32,648,846 32,673,047 RGD:1624291
G Tap1 transporter 1, ATP binding cassette subfamily B member JBrowse link 20 3,979,302 3,989,669 RGD:2312378
G Tap2 transporter 2, ATP binding cassette subfamily B member JBrowse link 20 3,995,544 4,009,587 RGD:2312378
tolerance induction to lipopolysaccharide term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Acod1 aconitate decarboxylase 1 JBrowse link 15 93,612,968 93,622,322 RGD:1624291
G Tnfaip3 TNF alpha induced protein 3 JBrowse link 1 14,401,103 14,416,369 RGD:1624291

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19332
    negative regulation of biological process 5553
      negative regulation of response to stimulus 1634
        negative regulation of response to biotic stimulus 94
          negative regulation of antimicrobial humoral response + 1
          negative regulation of defense response to bacterium + 5
          negative regulation of defense response to insect 0
          negative regulation of defense response to oomycetes 0
          negative regulation of defense response to virus + 25
          negative regulation of filamentous growth of a population of unicellular organisms in response to biotic stimulus 0
          negative regulation of innate immune response + 61
          negative regulation of lipopolysaccharide-mediated signaling pathway + 9
          negative regulation of neutrophil mediated killing of symbiont cell + 0
          negative regulation of response to tumor cell + 4
          negative regulation of xenophagy 0
Path 2
Term Annotations click to browse term
  biological_process 19332
    biological regulation 13335
      regulation of biological process 12650
        negative regulation of biological process 5553
          negative regulation of response to stimulus 1634
            negative regulation of response to biotic stimulus 94
              negative regulation of antimicrobial humoral response + 1
              negative regulation of defense response to bacterium + 5
              negative regulation of defense response to insect 0
              negative regulation of defense response to oomycetes 0
              negative regulation of defense response to virus + 25
              negative regulation of filamentous growth of a population of unicellular organisms in response to biotic stimulus 0
              negative regulation of innate immune response + 61
              negative regulation of lipopolysaccharide-mediated signaling pathway + 9
              negative regulation of neutrophil mediated killing of symbiont cell + 0
              negative regulation of response to tumor cell + 4
              negative regulation of xenophagy 0
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.