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ONTOLOGY REPORT - ANNOTATIONS


Term:response to ischemia
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Accession:GO:0002931 term browser browse the term
Definition:Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a inadequate blood supply.
Comment:Ischemia always results in hypoxia; however, hypoxia can occur without ischemia.


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response to ischemia term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abraxas2 abraxas 2, BRISC complex subunit ISO (PMID:21195082)
(MGI:MGI:5700295|PMID:21195082)
RGD PMID:21195082 MGI:MGI:5700295 NCBI chr 1:204,861,768...204,887,344
Ensembl chr 1:204,861,566...204,887,377
JBrowse link
G Aifm1 apoptosis inducing factor, mitochondria associated 1 NOT IEP RGD PMID:15181376, PMID:23685150 RGD:10047403, RGD:10053560 NCBI chr  X:135,304,063...135,343,062
Ensembl chr  X:135,304,066...135,343,087
JBrowse link
G Akt1 AKT serine/threonine kinase 1 IEP RGD PMID:24601882 RGD:39128160 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
JBrowse link
G Aldh2 aldehyde dehydrogenase 2 family member IEP RGD PMID:30131474 RGD:15036798 NCBI chr12:40,466,418...40,498,813
Ensembl chr12:40,466,495...40,498,752
JBrowse link
G Arid1b AT-rich interaction domain 1B IEP RGD PMID:14633620 RGD:1302474 NCBI chr 1:45,923,119...46,232,301
Ensembl chr 1:45,923,222...46,234,874
JBrowse link
G Bcl2 BCL2, apoptosis regulator ISO
IEA
MGI:MGI:1857430 (MGI:MGI:1351727|PMID:10488913)
GO_REF:0000107
RGD
Ensembl
PMID:10488913 GO_REF:0000107, MGI:MGI:1351727 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Bcl2l1 Bcl2-like 1 IDA RGD PMID:21410437 RGD:7349317 NCBI chr 3:148,259,594...148,314,191
Ensembl chr 3:148,259,596...148,313,810
JBrowse link
G Bcl2l2 Bcl2-like 2 IEP RGD PMID:10724126 RGD:14394498 NCBI chr15:33,543,774...33,549,165
Ensembl chr15:33,544,312...33,549,164
JBrowse link
G Bid BH3 interacting domain death agonist IEP RGD PMID:11934844 RGD:13782263 NCBI chr 4:153,439,812...153,465,247
Ensembl chr 4:153,442,218...153,465,203
JBrowse link
G Bves blood vessel epicardial substance ISO
ISS
(MGI:MGI:5550350|PMID:24066022)
GO_REF:0000024
RGD
UniProt
PMID:24066022 GO_REF:0000024, MGI:MGI:5550350 NCBI chr20:50,439,885...50,474,678
Ensembl chr20:50,439,883...50,474,678
JBrowse link
G Camk2a calcium/calmodulin-dependent protein kinase II alpha ISO
ISS
IEA
(MGI:MGI:5444772|PMID:23051746)
GO_REF:0000024
GO_REF:0000107
RGD
ParkinsonsUK-UCL
Ensembl
PMID:23051746 GO_REF:0000024, GO_REF:0000107, MGI:MGI:5444772 NCBI chr18:56,193,978...56,295,869
Ensembl chr18:56,193,978...56,295,869
JBrowse link
G Casp9 caspase 9 IEP RGD PMID:11934844 RGD:13782263 NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778
JBrowse link
G Casr calcium-sensing receptor IEP RGD PMID:21488219 RGD:7205700 NCBI chr11:67,188,204...67,262,261
Ensembl chr11:67,188,630...67,258,771
JBrowse link
G Cav1 caveolin 1 ISO
IEA
MGI:MGI:2180372 (MGI:MGI:3783955|PMID:17293479)
GO_REF:0000107
RGD
Ensembl
PMID:17293479 GO_REF:0000107, MGI:MGI:3783955 NCBI chr 4:44,597,123...44,630,206
Ensembl chr 4:44,597,123...44,630,200
JBrowse link
G Cib1 calcium and integrin binding 1 ISO
ISS
(MGI:MGI:3818804|PMID:17975111)
GO_REF:0000024
RGD
UniProt
PMID:17975111 GO_REF:0000024, MGI:MGI:3818804 NCBI chr 1:142,014,962...142,020,461
Ensembl chr 1:142,014,958...142,020,525
JBrowse link
G Cpeb4 cytoplasmic polyadenylation element binding protein 4 ISO (MGI:MGI:5520043|PMID:20937770) RGD PMID:20937770 MGI:MGI:5520043 NCBI chr10:15,984,520...16,047,209
Ensembl chr10:15,987,921...16,046,033
JBrowse link
G Csf1 colony stimulating factor 1 IEA
ISO
GO_REF:0000107
(PMID:8922060)
Ensembl
RGD
PMID:8922060 GO_REF:0000107 NCBI chr 2:210,522,370...210,550,546
Ensembl chr 2:210,522,375...210,550,560
JBrowse link
G Csf1r colony stimulating factor 1 receptor IEA
ISO
GO_REF:0000107
(MGI:MGI:6275569|PMID:8922060)
Ensembl
RGD
PMID:8922060 GO_REF:0000107, MGI:MGI:6275569 NCBI chr18:56,414,493...56,458,300
Ensembl chr18:56,414,488...56,458,300
JBrowse link
G Cx3cl1 C-X3-C motif chemokine ligand 1 IGI PMID:12059974 ARUK-UCL PMID:12059974 RGD:13673875 NCBI chr19:10,644,267...10,654,861
Ensembl chr19:10,644,244...10,653,800
JBrowse link
G Cx3cr1 C-X3-C motif chemokine receptor 1 IGI PMID:12059974 ARUK-UCL PMID:12059974 RGD:13673875 NCBI chr 8:128,740,756...128,754,514
Ensembl chr 8:128,740,756...128,754,514
JBrowse link
G Cycs cytochrome c, somatic IDA RGD PMID:21410437 RGD:7349317 NCBI chr 4:80,331,226...80,333,326
Ensembl chr 4:80,331,227...80,333,326
JBrowse link
G Eef2 eukaryotic translation elongation factor 2 IEP RGD PMID:15211596 RGD:10401223 NCBI chr 7:11,401,501...11,406,771
Ensembl chr 7:11,401,501...11,406,771
JBrowse link
G Eef2k eukaryotic elongation factor-2 kinase IEP RGD PMID:12920134 RGD:10401252 NCBI chr 1:190,780,211...190,839,926
Ensembl chr 1:190,780,236...190,842,324
JBrowse link
G Egr1 early growth response 1 IDA
ISO
IEA
PMID:1859855
(MGI:MGI:1928025|PMID:11100120)
GO_REF:0000107
RGD
Ensembl
PMID:11100120, PMID:1859855 GO_REF:0000107, MGI:MGI:1928025, RGD:11535086 NCBI chr18:27,657,903...27,660,101
Ensembl chr18:27,657,628...27,661,429
JBrowse link
G Eif4ebp1 eukaryotic translation initiation factor 4E binding protein 1 IEP RGD PMID:20736160 RGD:7242945 NCBI chr16:68,954,860...68,968,248
Ensembl chr16:68,954,875...68,968,248
JBrowse link
G Faim2 Fas apoptotic inhibitory molecule 2 ISO MGI:MGI:4888719 (MGI:MGI:4880811|PMID:21209208) RGD PMID:21209208 MGI:MGI:4880811 NCBI chr 7:141,158,769...141,185,781
Ensembl chr 7:141,157,963...141,185,710
JBrowse link
G Fgfr1 Fibroblast growth factor receptor 1 IEP RGD PMID:10521571 RGD:10402090 NCBI chr16:71,265,390...71,319,046
Ensembl chr16:71,266,248...71,319,449
JBrowse link
G Fn1 fibronectin 1 IEP RGD PMID:12482021 RGD:7205472 NCBI chr 9:78,900,111...78,969,018
Ensembl chr 9:78,900,103...78,969,078
JBrowse link
G Gja1 gap junction protein, alpha 1 IEP
ISO
(PMID:15919068) RGD PMID:15919068, PMID:24728265 RGD:11568671 NCBI chr20:37,876,650...37,889,097
Ensembl chr20:37,876,650...37,889,089
JBrowse link
G Gjb2 gap junction protein, beta 2 IEP RGD PMID:24728265 RGD:11568671 NCBI chr15:37,377,313...37,394,494
Ensembl chr15:37,377,316...37,383,277
JBrowse link
G Glrx glutaredoxin IEP RGD PMID:19938943 RGD:9686063 NCBI chr 2:2,606,032...2,615,944
Ensembl chr 2:2,605,996...2,615,944
JBrowse link
G Gpr31 G protein-coupled receptor 31 ISO (MGI:MGI:6377747|PMID:29227475) RGD PMID:29227475 MGI:MGI:6377747 NCBI chr 1:53,519,829...53,520,788
Ensembl chr 1:53,519,829...53,520,788
JBrowse link
G Gsr glutathione-disulfide reductase IEP RGD PMID:9434704 RGD:11059511 NCBI chr16:62,197,617...62,239,987
Ensembl chr16:62,197,617...62,241,361
JBrowse link
G Hk1 hexokinase 1 IDA RGD PMID:21410437 RGD:7349317 NCBI chr20:31,911,460...31,979,780
Ensembl chr20:31,912,262...31,956,649
JBrowse link
G Hk2 hexokinase 2 IDA RGD PMID:21410437 RGD:7349317 NCBI chr 4:113,559,396...113,609,897
Ensembl chr 4:113,559,427...113,610,243
JBrowse link
G Hspa1a heat shock protein family A (Hsp70) member 1A IEP RGD PMID:22526757 RGD:7257595 NCBI chr20:4,875,834...4,881,751
Ensembl chr20:4,877,324...4,879,779
JBrowse link
G Hspb1 heat shock protein family B (small) member 1 IEP RGD PMID:10559386 RGD:10402577 NCBI chr12:23,839,390...23,841,051
Ensembl chr12:23,839,399...23,841,049
JBrowse link
G Hspd1 heat shock protein family D (Hsp60) member 1 IEP RGD PMID:23447644 RGD:10402845 NCBI chr 9:61,680,529...61,691,202
Ensembl chr 9:61,680,530...61,690,956
JBrowse link
G Hyou1 hypoxia up-regulated 1 IEA
ISO
GO_REF:0000107
(MGI:MGI:1320999|PMID:9748521), (MGI:MGI:1931743|PMID:11231630)
Ensembl
RGD
PMID:9748521, PMID:11231630 GO_REF:0000107, MGI:MGI:1320999, MGI:MGI:1931743 NCBI chr 8:48,699,796...48,711,912
Ensembl chr 8:48,699,769...48,711,910
JBrowse link
G Kcnj11 potassium inwardly-rectifying channel, subfamily J, member 11 IEP RGD PMID:20971764 RGD:7296940 NCBI chr 1:102,103,093...102,107,134
Ensembl chr 1:102,103,094...102,106,127
JBrowse link
G Map2k3 mitogen activated protein kinase kinase 3 IEP RGD PMID:20550965 RGD:7243113 NCBI chr10:45,089,455...45,110,802
Ensembl chr10:47,182,433...47,203,753
JBrowse link
G Map2k6 mitogen-activated protein kinase kinase 6 IEP RGD PMID:20550965 RGD:7243113 NCBI chr10:98,707,160...98,823,054
Ensembl chr10:98,706,960...98,823,287
JBrowse link
G Map3k5 mitogen-activated protein kinase kinase kinase 5 IEP RGD PMID:20550965 RGD:7243113 NCBI chr 1:15,412,603...15,613,752
Ensembl chr 1:15,412,603...15,613,746
JBrowse link
G Mlycd malonyl-CoA decarboxylase IMP PMID:15105298 UniProt PMID:15105298 RGD:1600796 NCBI chr19:52,032,950...52,048,773
Ensembl chr19:52,032,886...52,048,753
JBrowse link
G Ndnf neuron-derived neurotrophic factor ISO (MGI:MGI:5607385|PMID:24706764) RGD PMID:24706764 MGI:MGI:5607385 NCBI chr 4:96,528,830...96,565,780 JBrowse link
G Nol3 nucleolar protein 3 IEA
ISO
GO_REF:0000107
(MGI:MGI:3710289|PMID:16505176)
Ensembl
RGD
PMID:16505176 GO_REF:0000107, MGI:MGI:3710289 NCBI chr19:37,232,567...37,236,668
Ensembl chr19:37,235,001...37,236,649
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 IEP RGD PMID:31399183 RGD:25823190 NCBI chr19:38,422,210...38,437,103
Ensembl chr19:38,422,164...38,437,180
JBrowse link
G P2rx2 purinergic receptor P2X 2 IMP PMID:12849743 ARUK-UCL PMID:12849743 RGD:13673769 NCBI chr12:52,397,666...52,401,005
Ensembl chr12:52,397,792...52,401,015
JBrowse link
G P2rx4 purinergic receptor P2X 4 IMP PMID:12849743 ARUK-UCL PMID:12849743 RGD:13673769 NCBI chr12:39,308,022...39,325,673
Ensembl chr12:39,308,025...39,325,673
JBrowse link
G Panx1 Pannexin 1 ISO MGI:MGI:1890615 (MGI:MGI:5306522|PMID:22147915) RGD PMID:22147915 MGI:MGI:5306522 NCBI chr 8:13,567,185...13,606,040
Ensembl chr 8:13,566,739...13,606,040
JBrowse link
G Panx2 pannexin 2 ISO
IEA
MGI:MGI:1860055 (MGI:MGI:5306522|PMID:22147915)
GO_REF:0000107
RGD
Ensembl
PMID:22147915 GO_REF:0000107, MGI:MGI:5306522 NCBI chr 7:130,042,948...130,053,034
Ensembl chr 7:130,042,947...130,053,032
JBrowse link
G Pdia3 protein disulfide isomerase family A, member 3 IEP RGD PMID:12872233 RGD:1624250 NCBI chr 3:113,376,983...113,400,707
Ensembl chr 3:113,376,983...113,400,707
JBrowse link
G Per2 period circadian regulator 2 ISO
ISS
(MGI:MGI:5546525|PMID:23977055)
GO_REF:0000024
RGD
UniProt
PMID:23977055 GO_REF:0000024, MGI:MGI:5546525 NCBI chr 9:98,555,154...98,597,362
Ensembl chr 9:98,555,169...98,597,359
JBrowse link
G Pink1 PTEN induced kinase 1 IEP RGD PMID:25791474 RGD:12903964 NCBI chr 5:156,677,146...156,689,258
Ensembl chr 5:156,677,146...156,689,415
JBrowse link
G Ppargc1a PPARG coactivator 1 alpha IEP RGD PMID:21302669 RGD:10059656 NCBI chr14:63,095,291...63,190,688
Ensembl chr14:63,095,720...63,187,009
JBrowse link
G Ppif peptidylprolyl isomerase F ISS
ISO
GO_REF:0000024
(MGI:MGI:3576003|PMID:15800626), (MGI:MGI:3603054|PMID:16103352)
UniProt
RGD
PMID:15800626, PMID:16103352 GO_REF:0000024, MGI:MGI:3576003, MGI:MGI:3603054 NCBI chr16:1,979,191...1,985,912
Ensembl chr16:1,979,191...1,985,908
JBrowse link
G Rcan1 regulator of calcineurin 1 ISO MGI:MGI:3641540 (MGI:MGI:3629336|PMID:16648267) RGD PMID:16648267 MGI:MGI:3629336 NCBI chr11:32,539,689...32,620,274
Ensembl chr11:32,539,683...32,550,539
JBrowse link
G Rest RE1-silencing transcription factor IEP
IDA
PMID:12657670
PMID:25108103
PMID:22371606
UniProt PMID:12657670, PMID:25108103, PMID:22371606 RGD:1299303, RGD:14397584, RGD:14397566 NCBI chr14:33,131,985...33,152,019
Ensembl chr14:33,134,511...33,164,141
JBrowse link
G Rnls renalase, FAD-dependent amine oxidase IEP RGD PMID:21297953 RGD:7327162 NCBI chr 1:251,828,285...252,101,963
Ensembl chr 1:251,828,290...252,100,759
JBrowse link
G Rock2 Rho-associated coiled-coil containing protein kinase 2 ISO (MGI:MGI:6271078|PMID:29353861) RGD PMID:29353861 MGI:MGI:6271078 NCBI chr 6:42,180,864...42,289,910
Ensembl chr 6:42,180,894...42,289,908
JBrowse link
G Sirt5 sirtuin 5 ISO MGI:MGI:5297911 (MGI:MGI:6101519|PMID:26388266) RGD PMID:26388266 MGI:MGI:6101519 NCBI chr17:23,986,710...24,013,854
Ensembl chr17:23,986,758...24,013,881
JBrowse link
G Slc26a5 solute carrier family 26 member 5 IEP RGD PMID:15925203 RGD:9479072 NCBI chr 4:9,795,811...9,860,904
Ensembl chr 4:9,821,541...9,860,571
JBrowse link
G Slc8a2 solute carrier family 8 member A2 IEA
ISO
GO_REF:0000107
(MGI:MGI:3796351|PMID:17884163)
Ensembl
RGD
PMID:17884163 GO_REF:0000107, MGI:MGI:3796351 NCBI chr 1:78,029,555...78,054,042
Ensembl chr 1:78,025,995...78,060,111
JBrowse link
G Sqstm1 sequestosome 1 IEP RGD PMID:23782269 RGD:13210581 NCBI chr10:35,704,728...35,716,316
Ensembl chr10:35,704,730...35,716,294
JBrowse link
G Stub1 STIP1 homology and U-box containing protein 1 IDA PMID:19953350 ARUK-UCL PMID:19953350 RGD:13507303 NCBI chr10:15,197,754...15,200,035
Ensembl chr10:15,197,803...15,200,117
JBrowse link
G Tigar TP53 induced glycolysis regulatory phosphatase ISO (MGI:MGI:5574521|PMID:24872551) RGD PMID:24872551 MGI:MGI:5574521 NCBI chr 4:159,635,145...159,654,108
Ensembl chr 4:159,635,153...159,654,063
JBrowse link
G Tp53 tumor protein p53 ISO MGI:MGI:1857263 (MGI:MGI:5319065|PMID:22044588) RGD PMID:22044588 MGI:MGI:5319065 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link
G Trem2 triggering receptor expressed on myeloid cells 2 ISO (MGI:MGI:6294162|PMID:28592261) RGD PMID:28592261 MGI:MGI:6294162 NCBI chr 9:14,611,541...14,618,076
Ensembl chr 9:14,611,561...14,618,013
JBrowse link
G Uchl1 ubiquitin C-terminal hydrolase L1 ISO MGI:MGI:1856882 (MGI:MGI:3033270|PMID:14695319) RGD PMID:14695319 MGI:MGI:3033270 NCBI chr14:43,133,224...43,143,942
Ensembl chr14:43,133,218...43,143,973
JBrowse link

Term paths to the root
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Term Annotations click to browse term
  biological_process 20015
    response to stimulus 10570
      response to stress 4060
        response to ischemia 69
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.