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ONTOLOGY REPORT - ANNOTATIONS


Term:cardiac conduction system development
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Accession:GO:0003161 term browser browse the term
Definition:The process whose specific outcome is the progression of the cardiac conduction system over time, from its formation to the mature structure. The cardiac conduction system consists of specialized cardiomyocytes that regulate the frequency of heart beat.
Synonyms:exact_synonym: cardiac impulse conducting system development;   heart conduction system development


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cardiac conduction system development term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bmpr1a bone morphogenetic protein receptor type 1A ISO (MGI:3653945|PMID:16037571) RGD PMID:16037571 MGI:3653945 NCBI chr16:10,758,278...10,852,170
Ensembl chr16:10,758,527...10,802,512
JBrowse link
G Cdc42 cell division cycle 42 ISO MGI:97350 (MGI:5052204|PMID:21690310) RGD PMID:21690310 MGI:5052204 NCBI chr 5:155,690,267...155,728,385
Ensembl chr 5:155,691,390...155,728,300
JBrowse link
G Gja5 gap junction protein, alpha 5 ISO MGI:2445466 (MGI:4412358|PMID:18599871), (MGI:5304955|PMID:22203979) RGD PMID:18599871, PMID:22203979 MGI:4412358, MGI:5304955 NCBI chr 2:199,162,745...199,184,942
Ensembl chr 2:199,162,745...199,184,939
JBrowse link
G Mir1 microRNA 1 ISO (MGI:5575655|PMID:17397913) RGD PMID:17397913 MGI:5575655 NCBI chr18:2,054,933...2,055,019 JBrowse link
G Nkx2-5 NK2 homeobox 5 ISO (PMID:15109497), (PMID:27207958)
MGI:106211 (MGI:5052204|PMID:21690310)
RGD PMID:15109497, PMID:21690310, PMID:27207958 MGI:5052204 NCBI chr10:16,635,989...16,638,758
Ensembl chr10:16,635,989...16,638,764
JBrowse link
G Nrg1 neuregulin 1 IEA
ISO
GO_REF:0000107
(MGI:2384269|PMID:12149465)
Ensembl
RGD
PMID:12149465 GO_REF:0000107, MGI:2384269 NCBI chr16:62,969,573...64,065,063
Ensembl chr16:63,837,216...64,057,434
JBrowse link
atrioventricular bundle cell differentiation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Tbx3 T-box transcription factor 3 ISO MGI:3710254 (MGI:3847383|PMID:18467625) RGD PMID:18467625 MGI:3847383 NCBI chr12:42,479,518...42,494,588
Ensembl chr12:42,480,560...42,492,526
JBrowse link
atrioventricular node cell development term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Maml1 mastermind-like transcriptional coactivator 1 ISO (MGI:5000164|PMID:21266778) RGD PMID:21266778 MGI:5000164 NCBI chr10:35,765,196...35,801,375
Ensembl chr10:35,765,719...35,800,120
JBrowse link
G Nkx2-5 NK2 homeobox 5 IEA
ISO
GO_REF:0000107
MGI:3042511 (MGI:4355491|PMID:19546853)
Ensembl
RGD
PMID:19546853 GO_REF:0000107, MGI:4355491 NCBI chr10:16,635,989...16,638,758
Ensembl chr10:16,635,989...16,638,764
JBrowse link
atrioventricular node cell fate commitment term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Nkx2-5 NK2 homeobox 5 IEA
ISO
GO_REF:0000107
MGI:3042511 (MGI:3040116|PMID:15109497)
Ensembl
RGD
PMID:15109497 GO_REF:0000107, MGI:3040116 NCBI chr10:16,635,989...16,638,758
Ensembl chr10:16,635,989...16,638,764
JBrowse link
atrioventricular node development term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Nkx2-5 NK2 homeobox 5 ISO (MGI:3829107|PMID:18689573) RGD PMID:18689573 MGI:3829107 NCBI chr10:16,635,989...16,638,758
Ensembl chr10:16,635,989...16,638,764
JBrowse link
G Notch1 notch receptor 1 ISO (MGI:5000164|PMID:21266778) RGD PMID:21266778 MGI:5000164 NCBI chr 3:3,905,562...3,951,015
Ensembl chr 3:3,905,453...3,951,025
JBrowse link
bundle of His development term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Id2 inhibitor of DNA binding 2 ISO MGI:2384134 (MGI:3716040|PMID:17604724) RGD PMID:17604724 MGI:3716040 NCBI chr 6:44,360,077...44,361,908
Ensembl chr 6:44,348,501...44,363,915
JBrowse link
G Nkx2-5 NK2 homeobox 5 IEA
ISO
GO_REF:0000107
MGI:102541 (MGI:3716040|PMID:17604724)
Ensembl
RGD
PMID:17604724 GO_REF:0000107, MGI:3716040 NCBI chr10:16,635,989...16,638,758
Ensembl chr10:16,635,989...16,638,764
JBrowse link
G Tbx5 T-box transcription factor 5 IEA
ISO
GO_REF:0000107
MGI:97350 (MGI:3716040|PMID:17604724)
Ensembl
RGD
PMID:17604724 GO_REF:0000107, MGI:3716040 NCBI chr12:42,059,688...42,148,226
Ensembl chr12:42,097,626...42,148,146
JBrowse link
Purkinje myocyte development term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dsg2 desmoglein 2 ISO (PMID:16505173) RGD PMID:16505173 NCBI chr18:15,579,322...15,637,720
Ensembl chr18:15,579,315...15,637,715
JBrowse link
Purkinje myocyte differentiation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Nkx2-5 NK2 homeobox 5 IEA
ISO
GO_REF:0000107
MGI:1857618 (MGI:3785685|PMID:17250822)
Ensembl
RGD
PMID:17250822 GO_REF:0000107, MGI:3785685 NCBI chr10:16,635,989...16,638,758
Ensembl chr10:16,635,989...16,638,764
JBrowse link
sinoatrial node cell development term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bves blood vessel epicardial substance ISO MGI:2385915 (MGI:5424322|PMID:22354168) RGD PMID:22354168 MGI:5424322 NCBI chr20:50,439,885...50,474,678
Ensembl chr20:50,439,883...50,474,678
JBrowse link
G Popdc2 popeye domain containing 2 ISO MGI:3773727 (MGI:5424322|PMID:22354168) RGD PMID:22354168 MGI:5424322 NCBI chr11:64,915,041...64,954,704
Ensembl chr11:64,936,692...64,952,687
JBrowse link
G Tbx3 T-box transcription factor 3 ISO MGI:3710254 (MGI:4366226|PMID:19096026) RGD PMID:19096026 MGI:4366226 NCBI chr12:42,479,518...42,494,588
Ensembl chr12:42,480,560...42,492,526
JBrowse link
sinoatrial node cell differentiation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mesp1 mesoderm posterior bHLH transcription factor 1 ISO (PMID:18297060) RGD PMID:18297060 NCBI chr 1:141,532,390...141,533,908
Ensembl chr 1:141,532,390...141,533,908
JBrowse link
sinoatrial node development term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Tbx18 T-box transcription factor 18 ISO MGI:3714982 (MGI:4366226|PMID:19096026) RGD PMID:19096026 MGI:4366226 NCBI chr 8:95,359,354...95,387,363
Ensembl chr 8:95,359,354...95,387,363
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20020
    developmental process 6826
      anatomical structure development 6268
        animal organ development 4033
          heart development 687
            cardiac muscle tissue development 257
              cardiac conduction system development 16
                His-Purkinje system development + 5
                atrioventricular node development + 3
                sinoatrial node development + 5
Path 2
Term Annotations click to browse term
  biological_process 20020
    developmental process 6826
      anatomical structure development 6268
        multicellular organism development 5743
          system development 5279
            animal organ development 4033
              heart development 687
                cardiac muscle tissue development 257
                  cardiac conduction system development 16
                    His-Purkinje system development + 5
                    atrioventricular node development + 3
                    sinoatrial node development + 5
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.