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ONTOLOGY REPORT - ANNOTATIONS


Term:endocardial cushion development
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Accession:GO:0003197 term browser browse the term
Definition:The progression of a cardiac cushion over time, from its initial formation to the mature structure. The endocardial cushion is a specialized region of mesenchymal cells that will give rise to the heart septa and valves.


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endocardial cushion development term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Bmp4 bone morphogenetic protein 4 JBrowse link 15 20,776,060 20,791,013 RGD:1624291
RGD:1600115
G Bmpr2 bone morphogenetic protein receptor type 2 JBrowse link 9 66,568,074 66,683,019 RGD:1624291
G Cited2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 JBrowse link 1 12,823,363 12,825,806 RGD:1624291
G Epha3 Eph receptor A3 JBrowse link 11 421,253 783,037 RGD:1624291
G Erbb3 erb-b2 receptor tyrosine kinase 3 JBrowse link 7 2,989,202 3,010,610 RGD:1624291
RGD:1600115
G Erg ETS transcription factor ERG JBrowse link 11 35,645,317 35,749,637 RGD:1624291
G Foxf1 forkhead box F1 JBrowse link 19 53,012,306 53,016,100 RGD:1624291
G Gata4 GATA binding protein 4 JBrowse link 15 46,386,703 46,458,679 RGD:1624291
G Nedd4 NEDD4 E3 ubiquitin protein ligase JBrowse link 8 79,323,408 79,408,842 RGD:1624291
RGD:1600115
G Notch1 notch receptor 1 JBrowse link 3 3,905,562 3,951,015 RGD:1624291
G Rbm24 RNA binding motif protein 24 JBrowse link 17 18,671,037 18,682,876 RGD:1624291
G Tbx5 T-box transcription factor 5 JBrowse link 12 42,059,688 42,148,226 RGD:1624291
RGD:1600115
G Thbs1 thrombospondin 1 JBrowse link 3 109,862,120 109,873,466 RGD:1624291
G Tmem100 transmembrane protein 100 JBrowse link 10 77,537,340 77,543,710 RGD:1624291
apoptotic process involved in endocardial cushion morphogenesis term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Bmp4 bone morphogenetic protein 4 JBrowse link 15 20,776,060 20,791,013 RGD:1624291
cell migration involved in endocardial cushion formation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Dchs1 dachsous cadherin-related 1 JBrowse link 1 170,594,981 170,629,062 RGD:1624291
G Eng endoglin JBrowse link 3 11,679,530 11,717,486 RGD:1624291
G Notch1 notch receptor 1 JBrowse link 3 3,905,562 3,951,015 RGD:1624291
G Snai2 snail family transcriptional repressor 2 JBrowse link 11 90,404,421 90,406,730 RGD:1624291
cell proliferation involved in endocardial cushion morphogenesis term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Tgfbr2 transforming growth factor, beta receptor 2 JBrowse link 8 124,310,288 124,399,345 RGD:1624291
endocardial cushion cell development term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Jag1 jagged canonical Notch ligand 1 JBrowse link 3 130,079,361 130,114,781 RGD:1624291
RGD:1600115
endocardial cushion cell fate commitment term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Acvr1 activin A receptor type 1 JBrowse link 3 44,432,476 44,539,680 RGD:1624291
RGD:1600115
endocardial cushion formation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Bmp5 bone morphogenetic protein 5 JBrowse link 8 82,669,466 82,950,273 RGD:1624291
G Bmp7 bone morphogenetic protein 7 JBrowse link 3 170,879,972 170,955,820 RGD:1624291
G Bmpr1a bone morphogenetic protein receptor type 1A JBrowse link 16 10,758,278 10,852,170 RGD:1624291
G Robo1 roundabout guidance receptor 1 JBrowse link 11 9,079,291 10,146,302 RGD:1624291
G Robo2 roundabout guidance receptor 2 JBrowse link 11 11,062,866 12,618,793 RGD:1624291
G Tbx20 T-box transcription factor 20 JBrowse link 8 25,849,394 25,904,570 RGD:1624291
endocardial cushion fusion term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Acvr1 activin A receptor type 1 JBrowse link 3 44,432,476 44,539,680 RGD:1624291
RGD:1600115
G Gata5 GATA binding protein 5 JBrowse link 3 175,701,278 175,709,465 RGD:1624291
G Tgfb2 transforming growth factor, beta 2 JBrowse link 13 105,039,639 105,142,010 RGD:1624291
G Tgfbr2 transforming growth factor, beta receptor 2 JBrowse link 8 124,310,288 124,399,345 RGD:1624291
endocardial cushion morphogenesis term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Acvr1 activin A receptor type 1 JBrowse link 3 44,432,476 44,539,680 RGD:1624291
G Acvrl1 activin A receptor like type 1 JBrowse link 7 142,769,942 142,787,336 RGD:1624291
G Bmp2 bone morphogenetic protein 2 JBrowse link 3 126,335,963 126,346,771 RGD:1600115
RGD:1624291
G Bmpr1a bone morphogenetic protein receptor type 1A JBrowse link 16 10,758,278 10,852,170 RGD:1624291
G Eng endoglin JBrowse link 3 11,679,530 11,717,486 RGD:1624291
G Hey1 hes-related family bHLH transcription factor with YRPW motif 1 JBrowse link 2 95,320,147 95,322,701 RGD:1624291
G Heyl hes-related family bHLH transcription factor with YRPW motif-like JBrowse link 5 140,923,914 140,940,905 RGD:1624291
G Isl1 ISL LIM homeobox 1 JBrowse link 2 48,488,911 48,501,217 RGD:1624291
G Mdm2 MDM2 proto-oncogene JBrowse link 7 60,719,060 60,743,618 RGD:1624291
G Mdm4 MDM4 regulator of p53 JBrowse link 13 49,786,776 49,828,780 RGD:1624291
G Nog noggin JBrowse link 10 76,811,759 76,813,386 RGD:1624291
RGD:1600115
G Nos3 nitric oxide synthase 3 JBrowse link 4 7,321,908 7,342,404 RGD:1600115
RGD:1624291
G Notch1 notch receptor 1 JBrowse link 3 3,905,562 3,951,015 RGD:1624291
G Sox9 SRY-box transcription factor 9 JBrowse link 10 101,288,528 101,294,030 RGD:1624291
RGD:1600115
G Tbx2 T-box transcription factor 2 JBrowse link 10 73,278,932 73,290,764 RGD:1624291
G Tbx20 T-box transcription factor 20 JBrowse link 8 25,849,394 25,904,570 RGD:1624291
G Tgfb2 transforming growth factor, beta 2 JBrowse link 13 105,039,639 105,142,010 RGD:1624291
G Twist1 twist family bHLH transcription factor 1 JBrowse link 6 53,401,241 53,403,235 RGD:1624291
epithelial to mesenchymal transition involved in endocardial cushion formation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Bmp4 bone morphogenetic protein 4 JBrowse link 15 20,776,060 20,791,013 RGD:1624291
G Eng endoglin JBrowse link 3 11,679,530 11,717,486 RGD:1624291
G Fgf8 fibroblast growth factor 8 JBrowse link 1 265,492,949 265,498,965 RGD:1624291
G Hey1 hes-related family bHLH transcription factor with YRPW motif 1 JBrowse link 2 95,320,147 95,322,701 RGD:1624291
G Heyl hes-related family bHLH transcription factor with YRPW motif-like JBrowse link 5 140,923,914 140,940,905 RGD:1624291
G Msx1 msh homeobox 1 JBrowse link 14 77,712,262 77,716,061 RGD:1624291
G Msx2 msh homeobox 2 JBrowse link 17 11,683,862 11,689,527 RGD:1624291
RGD:1600115
G Notch1 notch receptor 1 JBrowse link 3 3,905,562 3,951,015 RGD:1624291
G Rbpj recombination signal binding protein for immunoglobulin kappa J region JBrowse link 14 59,657,738 59,865,427 RGD:1624291
G Smad4 SMAD family member 4 JBrowse link 18 69,626,682 69,657,373 RGD:1624291
RGD:1600115
G Snai1 snail family transcriptional repressor 1 JBrowse link 3 164,274,710 164,279,199 RGD:1624291
G Snai2 snail family transcriptional repressor 2 JBrowse link 11 90,404,421 90,406,730 RGD:1624291
G Tmem100 transmembrane protein 100 JBrowse link 10 77,537,340 77,543,710 RGD:1624291
inferior endocardial cushion morphogenesis term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Tgfbr2 transforming growth factor, beta receptor 2 JBrowse link 8 124,310,288 124,399,345 RGD:1624291
negative regulation of epithelial to mesenchymal transition involved in endocardial cushion formation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Nog noggin JBrowse link 10 76,811,759 76,813,386 RGD:1624291
RGD:1600115
G Tgfb2 transforming growth factor, beta 2 JBrowse link 13 105,039,639 105,142,010 RGD:1624291
positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Acvr1 activin A receptor type 1 JBrowse link 3 44,432,476 44,539,680 RGD:1624291
RGD:1600115
G Eng endoglin JBrowse link 3 11,679,530 11,717,486 RGD:1624291
G Tgfb2 transforming growth factor, beta 2 JBrowse link 13 105,039,639 105,142,010 RGD:1624291
G Tgfbr1 transforming growth factor, beta receptor 1 JBrowse link 5 63,056,071 63,119,635 RGD:1624291
G Tgfbr2 transforming growth factor, beta receptor 2 JBrowse link 8 124,310,288 124,399,345 RGD:1624291
regulation of epithelial to mesenchymal transition involved in endocardial cushion formation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Tgfb1 transforming growth factor, beta 1 JBrowse link 1 82,480,875 82,497,196 RGD:1624291
G Tgfb3 transforming growth factor, beta 3 JBrowse link 6 109,913,757 109,936,217 RGD:1624291
superior endocardial cushion morphogenesis term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Tgfbr2 transforming growth factor, beta receptor 2 JBrowse link 8 124,310,288 124,399,345 RGD:1624291

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19576
    developmental process 6694
      anatomical structure development 6153
        tissue development 2075
          mesenchyme development 287
            endocardial cushion development 49
              endocardial cushion cell differentiation + 2
              endocardial cushion morphogenesis + 37
Path 2
Term Annotations click to browse term
  biological_process 19576
    developmental process 6694
      anatomical structure development 6153
        multicellular organism development 5621
          system development 5156
            circulatory system development 1218
              heart development 686
                endocardial cushion development 49
                  endocardial cushion cell differentiation + 2
                  endocardial cushion morphogenesis + 37
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.