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ONTOLOGY REPORT - ANNOTATIONS


Term:endocardial cushion to mesenchymal transition involved in heart valve formation
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Accession:GO:0003199 term browser browse the term
Definition:A transition where an endocardial cushion cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell that will contribute to the formation of a cardiac valve.
Synonyms:exact_synonym: endocardial cushion to mesenchymal transition involved in valve formation


show annotations for term's descendants           Sort by:
 
endocardial cushion to mesenchymal transition involved in heart valve formation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Efna1 ephrin A1 ISO (MGI:MGI:4847981|PMID:20960543) RGD PMID:20960543 MGI:MGI:4847981 NCBI chr 2:188,588,808...188,596,156
Ensembl chr 2:188,588,796...188,596,222
JBrowse link
G Erg ETS transcription factor ERG ISO MGI:MGI:5443838 (MGI:MGI:5442628|PMID:22932696) RGD PMID:22932696 MGI:MGI:5442628 NCBI chr11:35,645,317...35,749,637
Ensembl chr11:35,646,116...35,749,594
JBrowse link
G Hey1 hes-related family bHLH transcription factor with YRPW motif 1 ISO MGI:MGI:1341884 (MGI:MGI:3530185|PMID:15680351) RGD PMID:15680351 MGI:MGI:3530185 NCBI chr 2:95,320,147...95,322,701
Ensembl chr 2:95,320,283...95,322,696
JBrowse link
G Hey2 hes-related family bHLH transcription factor with YRPW motif 2 ISO MGI:MGI:1341800 (MGI:MGI:3530185|PMID:15680351) RGD PMID:15680351 MGI:MGI:3530185 NCBI chr 1:29,191,170...29,201,257
Ensembl chr 1:29,191,192...29,201,531
JBrowse link
positive regulation of endocardial cushion to mesenchymal transition involved in heart valve formation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Twist1 twist family bHLH transcription factor 1 ISO (MGI:MGI:4838344|PMID:20804746) RGD PMID:20804746 MGI:MGI:4838344 NCBI chr 6:53,401,241...53,403,235
Ensembl chr 6:53,401,109...53,403,214
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20027
    developmental process 6827
      anatomical structure formation involved in morphogenesis 1213
        heart valve formation 15
          endocardial cushion to mesenchymal transition involved in heart valve formation 5
            negative regulation of endocardial cushion to mesenchymal transition involved in heart valve formation 0
            positive regulation of endocardial cushion to mesenchymal transition involved in heart valve formation 1
            regulation of endocardial cushion to mesenchymal transition involved in heart valve formation + 1
Path 2
Term Annotations click to browse term
  biological_process 20027
    developmental process 6827
      anatomical structure development 6269
        multicellular organism development 5744
          system development 5280
            animal organ development 4035
              mesenchyme development 293
                mesenchymal cell differentiation 233
                  epithelial to mesenchymal transition 152
                    cardiac epithelial to mesenchymal transition 37
                      endocardial cushion to mesenchymal transition 8
                        endocardial cushion to mesenchymal transition involved in heart valve formation 5
                          negative regulation of endocardial cushion to mesenchymal transition involved in heart valve formation 0
                          positive regulation of endocardial cushion to mesenchymal transition involved in heart valve formation 1
                          regulation of endocardial cushion to mesenchymal transition involved in heart valve formation + 1
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.