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ONTOLOGY REPORT - ANNOTATIONS


Term:endocardial cushion to mesenchymal transition involved in heart valve formation
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Accession:GO:0003199 term browser browse the term
Definition:A transition where an endocardial cushion cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell that will contribute to the formation of a cardiac valve.
Synonyms:exact_synonym: endocardial cushion to mesenchymal transition involved in valve formation


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endocardial cushion to mesenchymal transition involved in heart valve formation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Efna1 ephrin A1 JBrowse link NW_004955545 1,610,929 1,617,217 RGD:9068941
G Hey2 hes related family bHLH transcription factor with YRPW motif 2 JBrowse link NW_004955436 7,060,930 7,070,610 RGD:9068941
positive regulation of endocardial cushion to mesenchymal transition involved in heart valve formation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Twist1 twist family bHLH transcription factor 1 JBrowse link NW_004955410 22,003,981 22,005,483 RGD:9068941

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 14516
    developmental process 5833
      anatomical structure formation involved in morphogenesis 1052
        heart valve formation 14
          endocardial cushion to mesenchymal transition involved in heart valve formation 3
            negative regulation of endocardial cushion to mesenchymal transition involved in heart valve formation 0
            positive regulation of endocardial cushion to mesenchymal transition involved in heart valve formation 1
            regulation of endocardial cushion to mesenchymal transition involved in heart valve formation + 1
Path 2
Term Annotations click to browse term
  biological_process 14516
    developmental process 5833
      anatomical structure development 5411
        multicellular organism development 4962
          system development 4449
            animal organ development 3267
              mesenchyme development 255
                mesenchymal cell differentiation 203
                  epithelial to mesenchymal transition 131
                    cardiac epithelial to mesenchymal transition 35
                      endocardial cushion to mesenchymal transition 6
                        endocardial cushion to mesenchymal transition involved in heart valve formation 3
                          negative regulation of endocardial cushion to mesenchymal transition involved in heart valve formation 0
                          positive regulation of endocardial cushion to mesenchymal transition involved in heart valve formation 1
                          regulation of endocardial cushion to mesenchymal transition involved in heart valve formation + 1
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.