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ONTOLOGY REPORT - ANNOTATIONS


Term:endocardial cushion to mesenchymal transition involved in heart valve formation
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Accession:GO:0003199 term browser browse the term
Definition:A transition where an endocardial cushion cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell that will contribute to the formation of a cardiac valve.
Synonyms:exact_synonym: endocardial cushion to mesenchymal transition involved in valve formation


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endocardial cushion to mesenchymal transition involved in heart valve formation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Efna1 ephrin A1 JBrowse link 3 89,271,730 89,280,951 RGD:2290270
G Erg ETS transcription factor JBrowse link 16 95,359,169 95,586,600 RGD:2290270
G Hey1 hairy/enhancer-of-split related with YRPW motif 1 JBrowse link 3 8,663,359 8,667,038 RGD:2290270
G Hey2 hairy/enhancer-of-split related with YRPW motif 2 JBrowse link 10 30,832,359 30,842,783 RGD:2290270
positive regulation of endocardial cushion to mesenchymal transition involved in heart valve formation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Twist1 twist basic helix-loop-helix transcription factor 1 JBrowse link 12 33,957,671 33,959,831 RGD:2290270

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 23109
    developmental process 6340
      anatomical structure formation involved in morphogenesis 1167
        heart valve formation 15
          endocardial cushion to mesenchymal transition involved in heart valve formation 5
            negative regulation of endocardial cushion to mesenchymal transition involved in heart valve formation 0
            positive regulation of endocardial cushion to mesenchymal transition involved in heart valve formation 1
            regulation of endocardial cushion to mesenchymal transition involved in heart valve formation + 1
Path 2
Term Annotations click to browse term
  biological_process 23109
    developmental process 6340
      anatomical structure development 5881
        multicellular organism development 5371
          system development 4772
            animal organ development 3510
              mesenchyme development 273
                mesenchymal cell differentiation 218
                  epithelial to mesenchymal transition 136
                    cardiac epithelial to mesenchymal transition 34
                      endocardial cushion to mesenchymal transition 8
                        endocardial cushion to mesenchymal transition involved in heart valve formation 5
                          negative regulation of endocardial cushion to mesenchymal transition involved in heart valve formation 0
                          positive regulation of endocardial cushion to mesenchymal transition involved in heart valve formation 1
                          regulation of endocardial cushion to mesenchymal transition involved in heart valve formation + 1
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.