ONTOLOGY REPORT - ANNOTATIONS


Term:endocardial cushion to mesenchymal transition involved in heart valve formation
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Accession:GO:0003199 term browser browse the term
Definition:A transition where an endocardial cushion cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell that will contribute to the formation of a cardiac valve.
Synonyms:exact_synonym: endocardial cushion to mesenchymal transition involved in valve formation


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endocardial cushion to mesenchymal transition involved in heart valve formation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Efna1 ephrin A1 JBrowse link 2 188,588,808 188,596,156 RGD:1624291
RGD:1600115
G Erg ETS transcription factor ERG JBrowse link 11 35,645,317 35,749,637 RGD:1624291
G Hey1 hes-related family bHLH transcription factor with YRPW motif 1 JBrowse link 2 95,320,147 95,322,701 RGD:1624291
G Hey2 hes-related family bHLH transcription factor with YRPW motif 2 JBrowse link 1 29,191,170 29,201,257 RGD:1624291
RGD:1600115
positive regulation of endocardial cushion to mesenchymal transition involved in heart valve formation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Twist1 twist family bHLH transcription factor 1 JBrowse link 6 53,401,241 53,403,235 RGD:1624291
RGD:1600115

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 17926
    developmental process 6339
      anatomical structure formation involved in morphogenesis 1167
        heart valve formation 15
          endocardial cushion to mesenchymal transition involved in heart valve formation 5
            negative regulation of endocardial cushion to mesenchymal transition involved in heart valve formation 0
            positive regulation of endocardial cushion to mesenchymal transition involved in heart valve formation 1
            regulation of endocardial cushion to mesenchymal transition involved in heart valve formation + 1
Path 2
Term Annotations click to browse term
  biological_process 17926
    developmental process 6339
      anatomical structure development 5946
        multicellular organism development 5440
          system development 5021
            animal organ development 3842
              mesenchyme development 280
                mesenchymal cell differentiation 220
                  epithelial to mesenchymal transition 141
                    cardiac epithelial to mesenchymal transition 37
                      endocardial cushion to mesenchymal transition 8
                        endocardial cushion to mesenchymal transition involved in heart valve formation 5
                          negative regulation of endocardial cushion to mesenchymal transition involved in heart valve formation 0
                          positive regulation of endocardial cushion to mesenchymal transition involved in heart valve formation 1
                          regulation of endocardial cushion to mesenchymal transition involved in heart valve formation + 1
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.