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ONTOLOGY REPORT - ANNOTATIONS


Term:endocardial cushion to mesenchymal transition involved in heart valve formation
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Accession:GO:0003199 term browser browse the term
Definition:A transition where an endocardial cushion cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell that will contribute to the formation of a cardiac valve.
Synonyms:exact_synonym: endocardial cushion to mesenchymal transition involved in valve formation


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positive regulation of endocardial cushion to mesenchymal transition involved in heart valve formation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Twist1 twist family bHLH transcription factor 1 JBrowse link NW_004936546 5,331,220 5,332,669 RGD:9068941

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 333
    developmental process 113
      anatomical structure formation involved in morphogenesis 16
        heart valve formation 1
          endocardial cushion to mesenchymal transition involved in heart valve formation 1
            negative regulation of endocardial cushion to mesenchymal transition involved in heart valve formation 0
            positive regulation of endocardial cushion to mesenchymal transition involved in heart valve formation 1
            regulation of endocardial cushion to mesenchymal transition involved in heart valve formation + 1
Path 2
Term Annotations click to browse term
  biological_process 333
    developmental process 113
      anatomical structure development 104
        multicellular organism development 94
          system development 81
            animal organ development 65
              mesenchyme development 5
                mesenchymal cell differentiation 5
                  epithelial to mesenchymal transition 3
                    cardiac epithelial to mesenchymal transition 2
                      endocardial cushion to mesenchymal transition 1
                        endocardial cushion to mesenchymal transition involved in heart valve formation 1
                          negative regulation of endocardial cushion to mesenchymal transition involved in heart valve formation 0
                          positive regulation of endocardial cushion to mesenchymal transition involved in heart valve formation 1
                          regulation of endocardial cushion to mesenchymal transition involved in heart valve formation + 1
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.