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ONTOLOGY REPORT - ANNOTATIONS


Term:negative regulation of Wnt signaling pathway involved in heart development
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Accession:GO:0003308 term browser browse the term
Definition:Any process that decreases the rate, frequency, or extent of the series of molecular signals initiated by binding of Wnt protein to a frizzled family receptor on the surface of the target cell, resulting a change in cell state that contributes to the progression of the heart over time.
Synonyms:exact_synonym: negative regulation of Wnt receptor signaling pathway involved in heart development;   negative regulation of Wnt receptor signalling pathway involved in heart development;   negative regulation of Wnt-activated signaling pathway involved in heart development


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negative regulation of Wnt signaling pathway involved in heart development term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alpk2 alpha-kinase 2 ISS
ISO
GO_REF:0000024
(PMID:29888752)
UniProt
RGD
PMID:29888752 GO_REF:0000024 NCBI chr18:60,960,009...61,072,116
Ensembl chr18:60,960,662...61,057,365
JBrowse link
G Bmp2 bone morphogenetic protein 2 ISO
ISS
(PMID:18545679)
GO_REF:0000024
RGD
UniProt
PMID:18545679 GO_REF:0000024 NCBI chr 3:126,335,963...126,346,771
Ensembl chr 3:126,335,863...126,346,318
JBrowse link
G Sox17 SRY-box transcription factor 17 ISO (MGI:3703823|PMID:17360443) RGD PMID:17360443 MGI:3703823 NCBI chr 5:14,890,318...14,895,907
Ensembl chr 5:14,890,408...14,895,907
JBrowse link
negative regulation of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dkk1 dickkopf WNT signaling pathway inhibitor 1 ISO (PMID:20559569) RGD PMID:20559569 NCBI chr 1:248,952,896...248,956,579
Ensembl chr 1:248,895,738...248,898,607
JBrowse link
negative regulation of planar cell polarity pathway involved in cardiac muscle tissue morphogenesis term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Lrp6 LDL receptor related protein 6 ISO MGI:98958 (MGI:4830282|PMID:19056682) RGD PMID:19056682 MGI:4830282 NCBI chr 4:168,194,054...168,323,962
Ensembl chr 4:168,194,927...168,323,751
JBrowse link
negative regulation of planar cell polarity pathway involved in cardiac right atrium morphogenesis term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Lrp6 LDL receptor related protein 6 ISO MGI:98958 (MGI:4830282|PMID:19056682) RGD PMID:19056682 MGI:4830282 NCBI chr 4:168,194,054...168,323,962
Ensembl chr 4:168,194,927...168,323,751
JBrowse link
negative regulation of planar cell polarity pathway involved in outflow tract morphogenesis term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Lrp6 LDL receptor related protein 6 ISO MGI:98958 (MGI:4830282|PMID:19056682) RGD PMID:19056682 MGI:4830282 NCBI chr 4:168,194,054...168,323,962
Ensembl chr 4:168,194,927...168,323,751
JBrowse link
negative regulation of planar cell polarity pathway involved in pericardium morphogenesis term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Lrp6 LDL receptor related protein 6 ISO MGI:98958 (MGI:4830282|PMID:19056682) RGD PMID:19056682 MGI:4830282 NCBI chr 4:168,194,054...168,323,962
Ensembl chr 4:168,194,927...168,323,751
JBrowse link
negative regulation of planar cell polarity pathway involved in ventricular septum morphogenesis term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Lrp6 LDL receptor related protein 6 ISO MGI:98958 (MGI:4830282|PMID:19056682) RGD PMID:19056682 MGI:4830282 NCBI chr 4:168,194,054...168,323,962
Ensembl chr 4:168,194,927...168,323,751
JBrowse link
positive regulation of heart induction by negative regulation of canonical Wnt signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dkk1 dickkopf WNT signaling pathway inhibitor 1 ISO (MGI:3835736|PMID:18297060) RGD PMID:18297060 MGI:3835736 NCBI chr 1:248,952,896...248,956,579
Ensembl chr 1:248,895,738...248,898,607
JBrowse link
G Mesp1 mesoderm posterior bHLH transcription factor 1 ISO (MGI:3835736|PMID:18297060) RGD PMID:18297060 MGI:3835736 NCBI chr 1:141,532,390...141,533,908
Ensembl chr 1:141,532,390...141,533,908
JBrowse link
G Wnt11 Wnt family member 11 ISO UniProtKB:P22725 (MGI:5424267|PMID:22569553) RGD PMID:22569553 MGI:5424267 NCBI chr 1:163,794,136...163,813,756
Ensembl chr 1:163,797,660...163,813,756
JBrowse link
G Wnt5a Wnt family member 5A IEA
ISO
GO_REF:0000107
UniProtKB:P48615 (MGI:5424267|PMID:22569553)
Ensembl
RGD
PMID:22569553 GO_REF:0000107, MGI:5424267 NCBI chr16:4,469,451...4,490,271
Ensembl chr16:4,469,468...4,489,860
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20020
    multicellular organismal process 9047
      negative regulation of multicellular organismal process 1124
        negative regulation of Wnt signaling pathway involved in heart development 8
          negative regulation of canonical Wnt signaling pathway involved in heart development + 1
          negative regulation of planar cell polarity pathway involved in heart morphogenesis + 1
          positive regulation of heart induction by negative regulation of canonical Wnt signaling pathway 4
Path 2
Term Annotations click to browse term
  biological_process 20020
    biological regulation 13769
      regulation of biological process 13071
        regulation of cellular process 12556
          signal transduction 7010
            cell surface receptor signaling pathway 2761
              cell surface receptor signaling pathway involved in cell-cell signaling 561
                Wnt signaling pathway 435
                  Wnt signaling pathway involved in heart development 14
                    regulation of Wnt signaling pathway involved in heart development 10
                      negative regulation of Wnt signaling pathway involved in heart development 8
                        negative regulation of canonical Wnt signaling pathway involved in heart development + 1
                        negative regulation of planar cell polarity pathway involved in heart morphogenesis + 1
                        positive regulation of heart induction by negative regulation of canonical Wnt signaling pathway 4
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.