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ONTOLOGY REPORT - ANNOTATIONS


Term:type B pancreatic cell differentiation
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Accession:GO:0003309 term browser browse the term
Definition:The process in which relatively unspecialized cells acquire specialized structural and/or functional features of a type B pancreatic cell. A type B pancreatic cell is a cell located towards center of the islets of Langerhans that secretes insulin.
Synonyms:exact_synonym: pancreatic B cell differentiation;   pancreatic beta cell differentiation


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type B pancreatic cell differentiation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gata6 GATA binding protein 6 ISO
IEA
(MGI:MGI:3701716|PMID:16887115)
GO_REF:0000107
RGD
Ensembl
PMID:16887115 GO_REF:0000107, MGI:MGI:3701716 NCBI chr18:2,415,821...2,447,087
Ensembl chr18:2,416,552...2,446,338
JBrowse link
G Insm1 INSM transcriptional repressor 1 ISO (MGI:MGI:3619850|PMID:16511571) RGD PMID:16511571 MGI:MGI:3619850 NCBI chr 3:140,427,961...140,430,467 JBrowse link
G Men1 menin 1 IMP RGD PMID:24157940 RGD:9589069 NCBI chr 1:221,704,394...221,710,343
Ensembl chr 1:221,704,493...221,710,331
JBrowse link
G Mir7-1 microRNA 7-1 ISO (MGI:MGI:5437569|PMID:22764048) RGD PMID:22764048 MGI:MGI:5437569 NCBI chr17:6,675,016...6,675,112
Ensembl chr17:6,675,016...6,675,112
JBrowse link
G Pax6 paired box 6 IMP
IEA
ISO
GO_REF:0000107
MGI:MGI:1934347 (MGI:MGI:5437569|PMID:22764048)
Ensembl
RGD
PMID:22764048, PMID:22403172 GO_REF:0000107, MGI:MGI:5437569, RGD:8552355 NCBI chr 3:95,700,241...95,728,682
Ensembl chr 3:95,707,386...95,728,624
JBrowse link
G Pdx1 pancreatic and duodenal homeobox 1 IMP
IBA
ISO
PMID:21108535
PMID:21873635
(PMID:12124776), (PMID:24567802)
RGD PMID:12124776, PMID:24567802, PMID:21108535, PMID:21873635 RGD:8553608, RGD:13792537 NCBI chr12:9,496,044...9,501,211
Ensembl chr12:9,496,044...9,501,213
JBrowse link
G Rfx6 regulatory factor X, 6 ISO (MGI:MGI:4422104|PMID:20148032) RGD PMID:20148032 MGI:MGI:4422104 NCBI chr20:32,709,282...32,764,040
Ensembl chr20:32,717,564...32,764,035
JBrowse link
G Vhl von Hippel-Lindau tumor suppressor ISO MGI:MGI:2136645|MGI:MGI:3608931 (MGI:MGI:5618205|PMID:25186293) RGD PMID:25186293 MGI:MGI:5618205 NCBI chr 4:145,580,869...145,587,835
Ensembl chr 4:145,580,799...145,587,845
JBrowse link
negative regulation of type B pancreatic cell development term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cftr CF transmembrane conductance regulator IMP RGD PMID:23178930 RGD:11567224 NCBI chr 4:42,693,263...42,860,679
Ensembl chr 4:42,692,836...42,860,676
JBrowse link
positive regulation of type B pancreatic cell development term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bad BCL2-associated agonist of cell death ISO
ISS
(MGI:MGI:3778846|PMID:18223655)
GO_REF:0000024
RGD
UniProt
PMID:18223655 GO_REF:0000024, MGI:MGI:3778846 NCBI chr 1:222,198,516...222,207,459
Ensembl chr 1:222,198,534...222,207,453
JBrowse link
G Rfx3 regulatory factor X3 ISO (MGI:MGI:4941444|PMID:20413507) RGD PMID:20413507 MGI:MGI:4941444 NCBI chr 1:245,853,332...246,110,648
Ensembl chr 1:245,859,633...246,110,218
JBrowse link
regulation of type B pancreatic cell development term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Arntl aryl hydrocarbon receptor nuclear translocator-like IEA
ISS
ISO
GO_REF:0000107
GO_REF:0000024
(MGI:MGI:4819446|PMID:20562852)
Ensembl
UniProt
RGD
PMID:20562852 GO_REF:0000024, GO_REF:0000107, MGI:MGI:4819446 NCBI chr 1:178,039,002...178,137,469
Ensembl chr 1:178,039,063...178,137,465
JBrowse link
G Clock clock circadian regulator IEA
ISS
ISO
GO_REF:0000107
GO_REF:0000024
(MGI:MGI:4819446|PMID:20562852)
Ensembl
UniProt
RGD
PMID:20562852 GO_REF:0000024, GO_REF:0000107, MGI:MGI:4819446 NCBI chr14:34,418,226...34,502,218
Ensembl chr14:34,446,616...34,502,218
JBrowse link
G Rheb Ras homolog, mTORC1 binding ISO
IEA
(PMID:19258434)
GO_REF:0000107
RGD
Ensembl
PMID:19258434 GO_REF:0000107 NCBI chr 4:6,827,429...6,873,384
Ensembl chr 4:6,827,429...6,873,383
JBrowse link
type B pancreatic cell development term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bmp4 bone morphogenetic protein 4 ISO
ISS
IEA
(PMID:11865031)
GO_REF:0000024
GO_REF:0000107
RGD
UniProt
Ensembl
PMID:11865031 GO_REF:0000024, GO_REF:0000107 NCBI chr15:20,776,060...20,791,013
Ensembl chr15:20,776,054...20,822,740
JBrowse link
G Bmp5 bone morphogenetic protein 5 ISO (PMID:11865031) RGD PMID:11865031 NCBI chr 8:82,669,466...82,950,273
Ensembl chr 8:82,878,941...82,950,273
JBrowse link
G Bmp6 bone morphogenetic protein 6 ISO (PMID:11865031) RGD PMID:11865031 NCBI chr17:26,955,142...27,112,820
Ensembl chr17:26,955,142...27,112,820
JBrowse link
G Cdk6 cyclin-dependent kinase 6 ISO (PMID:20668294) RGD PMID:20668294 NCBI chr 4:27,781,728...27,969,653
Ensembl chr 4:27,785,647...27,966,398
JBrowse link
G Dll1 delta like canonical Notch ligand 1 IEA
ISS
ISO
GO_REF:0000107
GO_REF:0000024
(MGI:MGI:5426345|PMID:22529374)
Ensembl
UniProt
RGD
PMID:22529374 GO_REF:0000024, GO_REF:0000107, MGI:MGI:5426345 NCBI chr 1:57,318,621...57,326,732
Ensembl chr 1:57,318,708...57,327,379
JBrowse link
G Hnf4a hepatocyte nuclear factor 4, alpha IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr 3:159,902,441...159,965,003
Ensembl chr 3:159,902,441...159,965,003
JBrowse link
G Insm1 INSM transcriptional repressor 1 ISO MGI:MGI:3656035 (MGI:MGI:3655758|PMID:16951258) RGD PMID:16951258 MGI:MGI:3655758 NCBI chr 3:140,427,961...140,430,467 JBrowse link
G Mir375 microRNA 375 ISO (MGI:MGI:3775688|PMID:17804764) RGD PMID:17804764 MGI:MGI:3775688 NCBI chr 9:82,161,716...82,161,790
Ensembl chr 9:82,161,716...82,161,790
JBrowse link
G Mir503 microRNA 503 ISO (MGI:MGI:3775688|PMID:17804764) RGD PMID:17804764 MGI:MGI:3775688 NCBI chr  X:158,148,476...158,148,546
Ensembl chr  X:158,148,476...158,148,546
JBrowse link
G Mir541 microRNA 541 ISO (MGI:MGI:3775688|PMID:17804764) RGD PMID:17804764 MGI:MGI:3775688 NCBI chr 6:133,892,655...133,892,744
Ensembl chr 6:133,892,655...133,892,744
JBrowse link
G Nkx2-2 NK2 homeobox 2 ISO MGI:MGI:1932100 (MGI:MGI:3703458|PMID:17202186), (MGI:MGI:3761395|PMID:17456846) RGD PMID:17202186, PMID:17456846 MGI:MGI:3703458, MGI:MGI:3761395 NCBI chr 3:141,408,460...141,419,083
Ensembl chr 3:141,408,798...141,411,170
JBrowse link
G Nkx6-1 NK6 homeobox 1 IEP RGD PMID:9603781 RGD:2326025 NCBI chr14:9,555,264...9,562,197
Ensembl chr14:9,555,264...9,562,189
JBrowse link
G Pdpk1 3-phosphoinositide dependent protein kinase-1 ISO (MGI:MGI:4365695|PMID:19635472) RGD PMID:19635472 MGI:MGI:4365695 NCBI chr10:13,446,373...13,525,248
Ensembl chr10:13,451,624...13,515,448
JBrowse link
G Sidt2 SID1 transmembrane family, member 2 ISO
IEA
MGI:MGI:5532825 (MGI:MGI:5529865|PMID:23776622)
GO_REF:0000107
RGD
Ensembl
PMID:23776622 GO_REF:0000107, MGI:MGI:5529865 NCBI chr 8:50,230,335...50,246,979
Ensembl chr 8:50,230,339...50,246,656
JBrowse link
G Smo smoothened, frizzled class receptor ISO
IEA
MGI:MGI:2176256|MGI:MGI:2684317 (MGI:MGI:4833770|PMID:20185815)
GO_REF:0000107
RGD
Ensembl
PMID:20185815 GO_REF:0000107, MGI:MGI:4833770 NCBI chr 4:57,019,941...57,041,779
Ensembl chr 4:57,019,941...57,042,770
JBrowse link
G Wnt5a Wnt family member 5A ISO
IEA
MGI:MGI:1857617 (MGI:MGI:3663526|PMID:16246260)
GO_REF:0000107
RGD
Ensembl
PMID:16246260 GO_REF:0000107, MGI:MGI:3663526 NCBI chr16:4,469,451...4,490,271
Ensembl chr16:4,469,468...4,489,860
JBrowse link
type B pancreatic cell fate commitment term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Nkx2-2 NK2 homeobox 2 ISO MGI:MGI:1932100 (MGI:MGI:3703458|PMID:17202186), (MGI:MGI:3768695|PMID:17988662) RGD PMID:17202186, PMID:17988662 MGI:MGI:3703458, MGI:MGI:3768695 NCBI chr 3:141,408,460...141,419,083
Ensembl chr 3:141,408,798...141,411,170
JBrowse link
type B pancreatic cell maturation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Rfx3 regulatory factor X3 ISO (MGI:MGI:4941444|PMID:20413507) RGD PMID:20413507 MGI:MGI:4941444 NCBI chr 1:245,853,332...246,110,648
Ensembl chr 1:245,859,633...246,110,218
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20017
    developmental process 6813
      anatomical structure development 6256
        endocrine pancreas development 51
          type B pancreatic cell differentiation 29
            type B pancreatic cell development + 22
            type B pancreatic cell fate commitment 1
Path 2
Term Annotations click to browse term
  biological_process 20017
    developmental process 6813
      anatomical structure development 6256
        tissue development 2094
          epithelium development 1257
            epithelial cell differentiation 707
              columnar/cuboidal epithelial cell differentiation 154
                glandular epithelial cell differentiation 59
                  enteroendocrine cell differentiation 33
                    type B pancreatic cell differentiation 29
                      type B pancreatic cell development + 22
                      type B pancreatic cell fate commitment 1
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.