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ONTOLOGY REPORT - ANNOTATIONS


Term:pancreatic A cell differentiation
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Accession:GO:0003310 term browser browse the term
Definition:The process in which relatively unspecialized cells acquire specialized structural and functional features of a pancreatic A cell. A pancreatic A cell is a cell in the pancreas that secretes glucagon.
Synonyms:exact_synonym: pancreatic alpha cell differentiation


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pancreatic A cell differentiation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gata6 GATA binding protein 6 ISO
IEA
(MGI:MGI:3701716|PMID:16887115)
GO_REF:0000107
RGD
Ensembl
PMID:16887115 GO_REF:0000107, MGI:MGI:3701716 NCBI chr18:2,415,821...2,447,087
Ensembl chr18:2,416,552...2,446,338
JBrowse link
G Insm1 INSM transcriptional repressor 1 ISO (MGI:MGI:3619850|PMID:16511571) RGD PMID:16511571 MGI:MGI:3619850 NCBI chr 3:140,427,961...140,430,467 JBrowse link
G Pax6 paired box 6 IMP RGD PMID:20592023 RGD:8552352 NCBI chr 3:95,700,241...95,728,682
Ensembl chr 3:95,707,386...95,728,624
JBrowse link
G Rfx6 regulatory factor X, 6 ISO (MGI:MGI:4422104|PMID:20148032) RGD PMID:20148032 MGI:MGI:4422104 NCBI chr20:32,709,282...32,764,040
Ensembl chr20:32,717,564...32,764,035
JBrowse link
G Vhl von Hippel-Lindau tumor suppressor ISO MGI:MGI:2136645|MGI:MGI:3608931 (MGI:MGI:5618205|PMID:25186293) RGD PMID:25186293 MGI:MGI:5618205 NCBI chr 4:145,580,869...145,587,835
Ensembl chr 4:145,580,799...145,587,845
JBrowse link
negative regulation of pancreatic A cell differentiation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hes1 hes family bHLH transcription factor 1 ISO
IEA
MGI:MGI:2149672 (MGI:MGI:1351379|PMID:10615124)
GO_REF:0000107
RGD
Ensembl
PMID:10615124 GO_REF:0000107, MGI:MGI:1351379 NCBI chr11:74,312,837...74,315,249
Ensembl chr11:74,312,806...74,315,248
JBrowse link
G Mir7-1 microRNA 7-1 ISO (MGI:MGI:5437569|PMID:22764048) RGD PMID:22764048 MGI:MGI:5437569 NCBI chr17:6,675,016...6,675,112
Ensembl chr17:6,675,016...6,675,112
JBrowse link
pancreatic A cell development term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pax6 paired box 6 ISO
IEA
IMP
(PMID:20592023)
GO_REF:0000107
(MGI:MGI:4943812|PMID:20592023)
RGD
Ensembl
PMID:20592023, PMID:20592023 GO_REF:0000107, MGI:MGI:4943812, RGD:8552352 NCBI chr 3:95,700,241...95,728,682
Ensembl chr 3:95,707,386...95,728,624
JBrowse link
pancreatic A cell fate commitment term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Neurod1 neuronal differentiation 1 ISO MGI:MGI:97347 (MGI:MGI:3768695|PMID:17988662) RGD PMID:17988662 MGI:MGI:3768695 NCBI chr 3:66,414,314...66,417,617
Ensembl chr 3:66,414,308...66,417,741
JBrowse link
G Nkx2-2 NK2 homeobox 2 ISO MGI:MGI:1339708|MGI:MGI:1932100 (MGI:MGI:3703458|PMID:17202186), (MGI:MGI:3768695|PMID:17988662) RGD PMID:17202186, PMID:17988662 MGI:MGI:3703458, MGI:MGI:3768695 NCBI chr 3:141,408,460...141,419,083
Ensembl chr 3:141,408,798...141,411,170
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20015
    developmental process 6813
      anatomical structure development 6257
        endocrine pancreas development 51
          pancreatic A cell differentiation 9
            negative regulation of pancreatic A cell differentiation 2
            pancreatic A cell development 1
            pancreatic A cell fate commitment 2
            positive regulation of pancreatic A cell differentiation 0
            regulation of pancreatic A cell differentiation + 2
Path 2
Term Annotations click to browse term
  biological_process 20015
    developmental process 6813
      anatomical structure development 6257
        tissue development 2094
          epithelium development 1257
            epithelial cell differentiation 707
              columnar/cuboidal epithelial cell differentiation 154
                glandular epithelial cell differentiation 59
                  enteroendocrine cell differentiation 33
                    pancreatic A cell differentiation 9
                      negative regulation of pancreatic A cell differentiation 2
                      pancreatic A cell development 1
                      pancreatic A cell fate commitment 2
                      positive regulation of pancreatic A cell differentiation 0
                      regulation of pancreatic A cell differentiation + 2
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.