Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   


Term:sphingosine-1-phosphate receptor signaling pathway
go back to main search page
Accession:GO:0003376 term browser browse the term
Definition:A series of molecular signals initiated by the sphingolipid sphingosine-1-phosphate (S1P) binding to a receptor on the surface of the cell, and which proceeds with the activated receptor transmitting the signal by promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The pathway ends with regulation of a downstream cellular process, e.g. transcription.
Comment:Merged terms see
Synonyms:exact_synonym: S1P receptor signaling pathway;   S1P-activated G-protein coupled receptor signaling pathway;   S1P-activated GPCR signaling pathway;   S1P-stimulated signal transduction pathway;   sphingolipid signalling pathway
 broad_synonym: sphingolipid signaling pathway
 related_synonym: S1P signaling pathway
 alt_id: GO:0001789

show annotations for term's descendants       view all columns           Sort by:
sphingosine-1-phosphate receptor signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ezr ezrin JBrowse link 1 47,287,872 47,331,412 RGD:1624291
G Gpr6 G protein-coupled receptor 6 JBrowse link 20 45,813,169 45,815,940 RGD:1624291
G S1pr1 sphingosine-1-phosphate receptor 1 JBrowse link 2 218,654,406 218,658,761 RGD:1624291
G S1pr2 sphingosine-1-phosphate receptor 2 JBrowse link 8 21,984,914 21,995,806 RGD:1624291
G S1pr3 sphingosine-1-phosphate receptor 3 JBrowse link 17 13,799,383 13,812,877 RGD:1600115
G S1pr4 sphingosine-1-phosphate receptor 4 JBrowse link 7 11,077,411 11,079,687 RGD:1600115
G S1pr5 sphingosine-1-phosphate receptor 5 JBrowse link 8 22,268,635 22,273,708 RGD:1600115
G Sphk2 sphingosine kinase 2 JBrowse link 1 101,692,972 101,700,604 RGD:1600115
G Spns2 sphingolipid transporter 2 JBrowse link 10 59,010,428 59,049,482 RGD:1624291

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 18166
    cellular process 16266
      signal transduction 6597
        sphingolipid mediated signaling pathway 13
          sphingosine-1-phosphate receptor signaling pathway 9
Path 2
Term Annotations click to browse term
  biological_process 18166
    biological regulation 12793
      regulation of biological process 12128
        regulation of cellular process 11458
          signal transduction 6597
            G protein-coupled receptor signaling pathway 2395
              sphingosine-1-phosphate receptor signaling pathway 9
paths to the root


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.