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ONTOLOGY REPORT - ANNOTATIONS


Term:DNA clamp loader activity
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Accession:GO:0003689 term browser browse the term
Definition:Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive the opening of the ring structure of the PCNA complex, or any of the related sliding clamp complexes, and their closing around the DNA duplex.
Synonyms:exact_synonym: DNA clamp loading ATPase activity
 narrow_synonym: PCNA loading activity;   PCNA loading complex activity
 xref: reactome:R-HSA-176264 "Recruitment of the Rad9-Hus1-Rad1 complex to DNA"


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DNA clamp loader activity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G CHTF18 chromosome transmission fidelity factor 18 JBrowse link 16 788,620 798,074 RGD:2290271
G CHTF8 chromosome transmission fidelity factor 8 JBrowse link 16 69,118,010 69,132,588 RGD:2290271
G DSCC1 DNA replication and sister chromatid cohesion 1 JBrowse link 8 119,833,960 119,855,920 RGD:2290271
G RAD17 RAD17 checkpoint clamp loader component JBrowse link 5 69,369,297 69,414,801 RGD:2290271
G RFC1 replication factor C subunit 1 JBrowse link 4 39,287,456 39,366,381 RGD:2290271
G RFC2 replication factor C subunit 2 JBrowse link 7 74,231,502 74,254,458 RGD:2290271
G RFC3 replication factor C subunit 3 JBrowse link 13 33,818,069 33,973,946 RGD:2290271
G RFC4 replication factor C subunit 4 JBrowse link 3 186,789,892 186,806,695 RGD:2290271
G RFC5 replication factor C subunit 5 JBrowse link 12 118,016,661 118,033,564 RGD:2290271

Term paths to the root
Path 1
Term Annotations click to browse term
  molecular_function 17874
    binding 15479
      organic cyclic compound binding 6223
        nucleic acid binding 4184
          DNA binding 2567
            DNA clamp loader activity 9
Path 2
Term Annotations click to browse term
  molecular_function 17874
    catalytic activity 5933
      hydrolase activity 2599
        hydrolase activity, acting on acid anhydrides 892
          hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 892
            pyrophosphatase activity 889
              nucleoside-triphosphatase activity 833
                ATPase activity 450
                  ATPase activity, coupled 297
                    DNA-dependent ATPase activity 118
                      protein-DNA loading ATPase activity 9
                        DNA clamp loader activity 9
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.