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ONTOLOGY REPORT - ANNOTATIONS


Term:peptidyl-prolyl cis-trans isomerase activity
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Accession:GO:0003755 term browser browse the term
Definition:Catalysis of the reaction: peptidyl-proline (omega=180) = peptidyl-proline (omega=0).
Synonyms:exact_synonym: PPIase activity;   cis-trans proline isomerase activity;   peptide bond isomerase activity;   peptidylproline cis-trans-isomerase activity;   peptidylprolyl cis-trans isomerase activity;   peptidylprolyl isomerase activity;   rotamase activity
 narrow_synonym: FK506-sensitive peptidyl-prolyl cis-trans isomerase;   cyclophilin-type peptidyl-prolyl cis-trans isomerase activity;   juglone-sensitive cis-trans proline isomerase activity;   juglone-sensitive peptidyl-prolyl cis-trans isomerase activity
 related_synonym: cyclophilin activity;   immunophilin;   parvulin;   peptidyl-prolyl isomerase B reaction
 alt_id: GO:0004752;   GO:0042028
 xref: EC:5.2.1.8;   MetaCyc:PEPTIDYLPROLYL-ISOMERASE-RXN;   RHEA:16237;   reactome:R-HSA-2022073 "Procollagen triple helix formation";   reactome:R-HSA-9626816 "PIN1 binds p-S345-NCF1"


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peptidyl-prolyl cis-trans isomerase activity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G AIP aryl hydrocarbon receptor interacting protein JBrowse link 2 5,042,883 5,048,885 RGD:14298760
G AIPL1 aryl hydrocarbon receptor interacting protein like 1 JBrowse link 12 50,903,358 50,917,187 RGD:14298760
G ARF3 ADP ribosylation factor 3 JBrowse link 5 14,973,477 14,993,016 RGD:14298760
G CWC27 CWC27 spliceosome associated cyclophilin JBrowse link 16 43,346,295 43,593,474 RGD:14298760
RGD:9068941
G FKBP10 FKBP prolyl isomerase 10 JBrowse link 12 20,872,155 20,881,604 RGD:14298760
G FKBP11 FKBP prolyl isomerase 11 JBrowse link 5 14,959,305 14,964,231 RGD:14298760
G FKBP14 FKBP prolyl isomerase 14 JBrowse link 18 42,903,100 42,913,609 RGD:14298760
G FKBP15 FKBP prolyl isomerase 15 JBrowse link 1 253,805,921 253,868,185 RGD:14298760
RGD:9068941
G FKBP1A FKBP prolyl isomerase 1A JBrowse link 17 33,910,047 33,935,212 RGD:14298760
G FKBP1B FKBP prolyl isomerase 1B JBrowse link 3 114,623,529 114,636,200 RGD:14298760
G FKBP2 FKBP prolyl isomerase 2 JBrowse link 2 7,868,229 7,871,184 RGD:14298760
G FKBP3 FKBP prolyl isomerase 3 JBrowse link 1 175,317,558 175,332,705 RGD:14298760
G FKBP4 FKBP prolyl isomerase 4 JBrowse link 5 67,314,010 67,321,628 RGD:14298760
G FKBP5 FKBP prolyl isomerase 5 JBrowse link 7 31,441,764 31,550,704 RGD:14298760
G FKBP6 FKBP prolyl isomerase 6 JBrowse link 3 10,659,456 10,716,210 RGD:14298760
RGD:9068941
G FKBP7 FKBP prolyl isomerase 7 JBrowse link 15 84,168,483 84,182,870 RGD:14298760
G FKBP8 FKBP prolyl isomerase 8 JBrowse link 2 59,256,546 59,267,171 RGD:14298760
G FKBP9 FKBP prolyl isomerase 9 JBrowse link 18 40,486,371 40,532,259 RGD:14298760
G LOC100511376 E3 SUMO-protein ligase RanBP2 JBrowse link 3 47,531,362 47,601,328 RGD:14298760
RGD:9068941
G LOC110258121 peptidyl-prolyl cis-trans isomerase A-like RGD:14298760
G NKTR natural killer cell triggering receptor JBrowse link 13 26,125,064 26,176,395 RGD:14298760
G PIN1 peptidylprolyl cis/trans isomerase, NIMA-interacting 1 JBrowse link 2 68,715,898 68,729,471 RGD:14298760
G PIN4 peptidylprolyl cis/trans isomerase, NIMA-interacting 4 JBrowse link X 58,069,758 58,082,243 RGD:14298760
G PPIA peptidylprolyl isomerase A JBrowse link 18 50,563,130 50,566,857 RGD:14298760
G PPIB peptidylprolyl isomerase B JBrowse link 1 107,886,663 107,893,155 RGD:14298760
G PPIC peptidylprolyl isomerase C JBrowse link 2 126,531,356 126,547,775 RGD:14298760
G PPID peptidylprolyl isomerase D JBrowse link 8 47,656,269 47,702,805 RGD:14298760
G PPIE peptidylprolyl isomerase E JBrowse link 6 95,548,582 95,566,470 RGD:14298760
G PPIF peptidylprolyl isomerase F JBrowse link 14 81,674,671 81,681,977 RGD:14298760
G PPIG peptidylprolyl isomerase G JBrowse link 15 75,940,397 75,979,168 RGD:14298760
G PPIH peptidylprolyl isomerase H JBrowse link 6 168,741,999 168,760,350 RGD:14298760
G PPIL1 peptidylprolyl isomerase like 1 JBrowse link 7 32,522,736 32,547,874 RGD:14298760
G PPIL2 peptidylprolyl isomerase like 2 JBrowse link 14 50,206,807 50,232,845 RGD:14298760
RGD:9068941
G PPIL3 peptidylprolyl isomerase like 3 JBrowse link 15 104,569,138 104,583,752 RGD:14298760
G PPIL4 peptidylprolyl isomerase like 4 JBrowse link 1 16,400,938 16,446,860 RGD:14298760
G PPIL6 peptidylprolyl isomerase like 6 JBrowse link 1 75,465,290 75,508,250 RGD:14298760
RGD:9068941
G PPWD1 peptidylprolyl isomerase domain and WD repeat containing 1 JBrowse link 16 44,080,617 44,113,064 RGD:14298760
G PTPA protein phosphatase 2 phosphatase activator JBrowse link 1 269,401,776 269,431,465 RGD:14298760

Term paths to the root
Path 1
Term Annotations click to browse term
  molecular_function 17331
    catalytic activity 5430
      catalytic activity, acting on a protein 2107
        peptidyl-prolyl cis-trans isomerase activity 38
Path 2
Term Annotations click to browse term
  molecular_function 17331
    catalytic activity 5430
      isomerase activity 146
        cis-trans isomerase activity 41
          peptidyl-prolyl cis-trans isomerase activity 38
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.