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ONTOLOGY REPORT - ANNOTATIONS


Term:protein disulfide isomerase activity
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Accession:GO:0003756 term browser browse the term
Definition:Catalysis of the rearrangement of both intrachain and interchain disulfide bonds in proteins.
Synonyms:exact_synonym: disulphide bond biosynthesis;   disulphide bond formation;   protein disulphide isomerase activity;   protein thiol-disulfide exchange;   protein thiol-disulphide exchange
 broad_synonym: protein disulfide-isomerase
 related_synonym: S-S rearrangase activity;   protein cysteine-thiol oxidation;   protein disulfide-isomerase reaction
 alt_id: GO:0006467
 xref: EC:5.3.4.1;   MetaCyc:5.3.4.1-RXN;   reactome:R-HSA-8950113 "IL12A binds IL12B";   reactome:R-HSA-8950183 "IL12B binds IL23A";   reactome:R-HSA-8950456 "IL12B dimerizes"


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protein disulfide isomerase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Creld1 cysteine-rich with EGF-like domains 1 IEA GO_REF:0000003 UniProt GO_REF:0000003 NCBI chr 4:145,440,284...145,449,894
Ensembl chr 4:145,440,114...145,449,892
JBrowse link
G Creld2 cysteine-rich with EGF-like domains 2 IEA GO_REF:0000003 UniProt GO_REF:0000003 NCBI chr 7:129,812,746...129,819,641
Ensembl chr 7:129,812,789...129,819,634
JBrowse link
G Ero1a endoplasmic reticulum oxidoreductase 1 alpha IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr15:19,619,947...19,655,381
Ensembl chr15:19,619,973...19,655,381
JBrowse link
G Ero1b endoplasmic reticulum oxidoreductase 1 beta IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr17:90,709,394...90,783,110
Ensembl chr17:90,710,555...90,756,048
JBrowse link
G Erp27 endoplasmic reticulum protein 27 NOT IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 4:170,893,946...170,912,629
Ensembl chr 4:170,893,946...170,912,629
JBrowse link
G Erp44 endoplasmic reticulum protein 44 ISO (PMID:11847130) RGD PMID:11847130 NCBI chr 5:63,937,866...64,030,827
Ensembl chr 5:63,937,784...64,030,901
JBrowse link
G Itgb3 integrin subunit beta 3 ISO (PMID:12204115), (PMID:15466936) RGD PMID:12204115, PMID:15466936 NCBI chr10:92,667,869...92,783,413
Ensembl chr10:92,667,869...92,783,410
JBrowse link
G P4hb prolyl 4-hydroxylase subunit beta IMP
ISO
IBA
(PMID:15225124), (PMID:15720785), (PMID:21091435)
PMID:21873635
RGD PMID:15225124, PMID:15720785, PMID:21091435, PMID:2841089, PMID:21873635 RGD:633506, RGD:13792537 NCBI chr10:109,736,459...109,748,070
Ensembl chr10:109,736,458...109,747,987
JBrowse link
G Pdia3 protein disulfide isomerase family A, member 3 IEA
IBA
GO_REF:0000003
PMID:21873635
UniProt PMID:21873635 GO_REF:0000003, RGD:13792537 NCBI chr 3:113,376,983...113,400,707
Ensembl chr 3:113,376,983...113,400,707
JBrowse link
G Pdia4 protein disulfide isomerase family A, member 4 IDA
IBA
IEA
PMID:21873635
GO_REF:0000003
PMID:22665516
UniProt PMID:8477750, PMID:21873635, PMID:22665516 GO_REF:0000003, RGD:632673, RGD:13792537, RGD:8553430 NCBI chr 4:77,470,636...77,489,535
Ensembl chr 4:77,470,636...77,489,535
JBrowse link
G Pdia5 protein disulfide isomerase family A, member 5 IEA GO_REF:0000003 UniProt GO_REF:0000003 NCBI chr11:68,493,035...68,578,999
Ensembl chr11:68,493,035...68,578,995
JBrowse link
G Pdia6 protein disulfide isomerase family A, member 6 ISS
IEA
GO_REF:0000024
GO_REF:0000002
UniProt
InterPro
GO_REF:0000002, GO_REF:0000024 NCBI chr 6:42,568,269...42,585,654
Ensembl chr 6:42,568,220...42,585,652
JBrowse link
G Pdilt protein disulfide isomerase-like, testis expressed ISO MGI:MGI:5316367 (MGI:MGI:5314820|PMID:22357757) RGD PMID:22357757 MGI:MGI:5314820 NCBI chr 1:189,207,164...189,238,796
Ensembl chr 1:189,207,165...189,238,776
JBrowse link
G Qsox1 quiescin sulfhydryl oxidase 1 ISS
IBA
ISO
GO_REF:0000024
PMID:21873635
(PMID:17331072), (PMID:18393449)
UniProt
RGD
PMID:17331072, PMID:18393449, PMID:21873635 GO_REF:0000024, RGD:13792537 NCBI chr13:73,423,396...73,460,890
Ensembl chr13:73,423,397...73,460,935
JBrowse link
G Qsox2 quiescin sulfhydryl oxidase 2 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 3:3,662,324...3,691,972
Ensembl chr 3:3,662,324...3,691,972
JBrowse link
G Txndc2 thioredoxin domain containing 2 ISO (MGI:MGI:2384156|PMID:12149401) RGD PMID:12149401 MGI:MGI:2384156 NCBI chr 9:113,354,047...113,358,558
Ensembl chr 9:113,354,053...113,358,526
JBrowse link
G Txndc5 thioredoxin domain containing 5 IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr17:26,925,828...26,953,981
Ensembl chr17:26,925,828...26,953,970
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  molecular_function 20467
    catalytic activity 6067
      catalytic activity, acting on a protein 2312
        protein disulfide isomerase activity 17
Path 2
Term Annotations click to browse term
  molecular_function 20467
    catalytic activity 6067
      isomerase activity 181
        intramolecular oxidoreductase activity 63
          intramolecular oxidoreductase activity, transposing S-S bonds 17
            protein disulfide isomerase activity 17
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.