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Term:GTPase activity
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Accession:GO:0003924 term browser browse the term
Definition:Catalysis of the reaction: GTP + H2O = GDP + phosphate.
Synonyms:narrow_synonym: ARF small monomeric GTPase activity;   RHEB small monomeric GTPase activity;   Rab small monomeric GTPase activity;   Ran small monomeric GTPase activity;   Ras small monomeric GTPase activity;   Rho small monomeric GTPase activity;   Sar small monomeric GTPase activity;   dynamin GTPase activity;   heterotrimeric G-protein GTPase activity;   protein-synthesizing GTPase activity;   protein-synthesizing GTPase activity, elongation;   protein-synthesizing GTPase activity, initiation;   protein-synthesizing GTPase activity, termination;   signal-recognition-particle GTPase activity;   small monomeric GTPase activity;   tubulin GTPase activity
 broad_synonym: hydrolase activity, acting on acid anhydrides, acting on GTP, involved in cellular and subcellular movement
 related_synonym: GTPase activity, coupled;   heterotrimeric G-protein GTPase, alpha-subunit;   heterotrimeric G-protein GTPase, beta-subunit;   heterotrimeric G-protein GTPase, gamma-subunit
 alt_id: GO:0061745
 xref: RHEA:19669;   reactome:R-HSA-1445143 "RAB8A,10,13,14 hydrolyze GTP";   reactome:R-HSA-1458485 "RALA hydrolyzes GTP";   reactome:R-HSA-156923 "Hydrolysis of eEF1A:GTP";   reactome:R-HSA-164381 "G alpha (s) auto-inactivates by hydrolysing GTP to GDP";   reactome:R-HSA-165055 "Hydrolysis of Ran:GTP to Ran:GDP";   reactome:R-HSA-167415 "G-protein alpha subunit is inactivated";   reactome:R-HSA-170666 "Adenylate cyclase increases the GTPase activity of G alpha-olf";   reactome:R-HSA-170685 "Adenylaye cyclase increases the GTPase activity of G alpha-olf";   reactome:R-HSA-170686 "Adenylate cyclase increases the GTPase activity of Gi alpha";   reactome:R-HSA-177501 "Endocytosis (internalization) of clathrin-coated vesicle";   reactome:R-HSA-203973 "Vesicle budding";   reactome:R-HSA-2130641 "Translocation of TGN-lysosome vesicle to lysosome";   reactome:R-HSA-2130725 "Internalization of MHC II:Ii clathrin coated vesicle";   reactome:R-HSA-2584246 "GNAT1-GTP hydrolyses its bound GTP to GDP";   reactome:R-HSA-380979 "RHEB in mTORC1:RHEB:GTP hydrolyses GTP";   reactome:R-HSA-392133 "G alpha (z) auto-inactivates by hydrolysing GTP to GDP";   reactome:R-HSA-392212 "G alpha (i) auto-inactivates by hydrolysing GTP to GDP";   reactome:R-HSA-418574 "G alpha (12/13) auto-inactivates by hydrolysing GTP to GDP";   reactome:R-HSA-418582 "G alpha (q) auto-inactivates by hydrolysing GTP to GDP";   reactome:R-HSA-421835 "trans-Golgi Network Vesicle Scission";   reactome:R-HSA-428941 "P2Y purinoceptor 1 activates MAP kinase p38 alpha";   reactome:R-HSA-432707 "trans-Golgi Network Lysosomal Vesicle Scission";   reactome:R-HSA-5333615 "80S:Met-tRNAi:mRNA:SECISBP2:Sec-tRNA(Sec):EEFSEC:GTP is hydrolysed to 80S:Met-tRNAi:mRNA:SECISBP2:Sec and EEFSEC:GDP by EEFSEC";   reactome:R-HSA-5389839 "39S subunit binds 28S subunit:mRNA:fMet-tRNA";   reactome:R-HSA-5389842 "TUFM hydrolyzes GTP and TUFM:GDP dissociates from 55S ribosome";   reactome:R-HSA-5419273 "Hydrolysis of GTP and dissociation of 28S and 39S subunits";   reactome:R-HSA-5419279 "Translocation of peptidyl-tRNA from A-site to P-site (and translocation of 55S ribosome by 3 bases along mRNA)";   reactome:R-HSA-555065 "Formation of clathrin coated vesicle";   reactome:R-HSA-5623513 "ASAP1 stimulates GTPase activity of ARF4";   reactome:R-HSA-5638006 "ARL3 hydrolyzes GTP";   reactome:R-HSA-5658231 "RAS GAPs stimulate RAS GTPase activity";   reactome:R-HSA-5665809 "SRGAP2 stimulates RAC1 GTP-ase activity and ends FMNL1-mediated elongation of actin filaments";   reactome:R-HSA-5672017 "Rheb in the mTORC1 complex hydrolyses GTP";   reactome:R-HSA-5694527 "Loss of SAR1B GTPase";   reactome:R-HSA-6807877 "ARFGAPs stimulate ARF GTPase activity";   reactome:R-HSA-6814833 "TBC1D20 stimulates GTPase activity of RAB1, resulting in hydrolysis of GTP";   reactome:R-HSA-8847534 "RAB43 hydrolyses GTP";   reactome:R-HSA-8847883 "CYTH proteins stimulate ARF1 GTPase activity";   reactome:R-HSA-8849082 "ARHGAP35 stimulates RHOA GTPase activity";   reactome:R-HSA-8854173 "TBC RabGAPs accelerate GTP hydrolysis by RAB35";   reactome:R-HSA-8854255 "TBC1D2A accelerates GTP hydrolysis by RAB7";   reactome:R-HSA-8854329 "TBC1D15 accelerates GTP hydrolysis by RAB7";   reactome:R-HSA-8854604 "TBC1D16 accelerates GTP hydrolysis by RAB4A";   reactome:R-HSA-8854612 "TBC1D25 accelerates GTP hydrolysis by RAB33B";   reactome:R-HSA-8868661 "Dynamin-mediated GTP hydrolysis promotes vesicle scission";   reactome:R-HSA-8981353 "RASA1 stimulates RAS GTPase activity";   reactome:R-HSA-8982020 "G alpha (i)i1/i2/i3 in G (i):RGS complex is inactivated";   reactome:R-HSA-8982021 "G alpha (z) in G alpha (z):RGS complex is inactivated";   reactome:R-HSA-8982025 "G alpha (q) in G (q):RGS complex is inactivated";   reactome:R-HSA-983422 "Disassembly of COPII coated vesicle"

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GTPase activity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Gna11 G protein subunit alpha 11 JBrowse link NW_004936588 1,770,777 1,789,143 RGD:9068941
G Sar1a secretion associated Ras related GTPase 1A JBrowse link NW_004936521 8,422,511 8,439,945 RGD:9068941

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  molecular_function 323
    catalytic activity 83
      hydrolase activity 41
        hydrolase activity, acting on acid anhydrides 5
          hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 5
            pyrophosphatase activity 5
              nucleoside-triphosphatase activity 5
                GTPase activity 2
                  GTPase motor activity + 0
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.