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ONTOLOGY REPORT - ANNOTATIONS


Term:aconitate hydratase activity
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Accession:GO:0003994 term browser browse the term
Definition:Catalysis of the reaction: citrate = isocitrate. The reaction occurs in two steps: (1) citrate = cis-aconitate + H2O, (2) cis-aconitate + H2O = isocitrate. This reaction is the interconversion of citrate and isocitrate via the labile, enzyme-bound intermediate cis-aconitate. Water is removed from one part of the citrate molecule and added back to a different atom to form isocitrate.
Comment:This is a process composed of two reactions represented by the terms 'GO:0052632 : citrate hydro-lyase (cis-aconitate-forming) activity' and 'GO:0052633 : isocitrate hydro-lyase (cis-aconitate-forming) activity'.
Synonyms:exact_synonym: aconitase activity
 broad_synonym: citrate hydro-lyase activity
 related_synonym: cis-aconitase activity;   citrate(isocitrate) hydro-lyase (cis-aconitate-forming);   citrate(isocitrate) hydro-lyase activity
 xref: EC:4.2.1.3;   RHEA:10336;   reactome:R-HSA-450975 "isocitrate <=> citrate";   reactome:R-HSA-5690911 "ACO1:4Fe-4S isomerises CIT to ISCIT";   reactome:R-HSA-70971 "citrate <=> isocitrate"


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aconitate hydratase activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aco1 aconitase 1 IDA
ISO
IEA
IBA
ISS
(MGI:3028434|PMID:14726953), (MGI:3521564|PMID:15604406)
GO_REF:0000003
PMID:21873635
(PMID:1281544), (PMID:1946430), (PMID:8041788)
GO_REF:0000024
RGD
UniProt
PMID:1281544, PMID:1946430, PMID:8041788, PMID:14726953, PMID:15604406, PMID:11264001, PMID:21873635, PMID:9092825 GO_REF:0000003, GO_REF:0000024, MGI:3028434, MGI:3521564, RGD:1642739, RGD:13792537, RGD:1642740 NCBI chr 5:56,425,076...56,481,218
Ensembl chr 5:56,425,024...56,481,218
JBrowse link
G Aco2 aconitase 2 IDA
ISO
IBA
(MGI:3522379|PMID:15317809), (MGI:3709427|PMID:17322295)
(PMID:1052766)
PMID:21873635
RGD PMID:1052766, PMID:15317809, PMID:17322295, PMID:12139479, PMID:14674759, PMID:9712727, PMID:21873635 MGI:3522379, MGI:3709427, RGD:632269, RGD:2306852, RGD:2306877, RGD:13792537 NCBI chr 7:123,102,493...123,145,608
Ensembl chr 7:123,102,468...123,145,635
JBrowse link
G Ireb2 iron responsive element binding protein 2 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 8:59,450,974...59,503,634
Ensembl chr 8:59,420,123...59,501,118
JBrowse link

Term paths to the root
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Term Annotations click to browse term
  molecular_function 20457
    catalytic activity 6065
      lyase activity 212
        carbon-oxygen lyase activity 92
          hydro-lyase activity 71
            aconitate hydratase activity 3
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.