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Term:arachidonate 5-lipoxygenase activity
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Accession:GO:0004051 term browser browse the term
Definition:Catalysis of the reaction: arachidonate + O2 = (6E,8Z,11Z,14Z)-(5S)-5-hydroperoxycosa-6,8,11,14-tetraenoate.
Synonyms:exact_synonym: 5-lipoxygenase activity;   5Delta-lipoxygenase activity;   arachidonate:oxygen 5-oxidoreductase activity;   arachidonic 5-lipoxygenase activity;   arachidonic acid 5-lipoxygenase activity;   delta5-lipoxygenase activity;   leukotriene-A4 synthase activity
 narrow_synonym: LTA synthase activity;   leukotriene-A(4) synthase activity
 broad_synonym: leukotriene A4 synthase
 related_synonym: C-5-lipoxygenase activity;   delta(5)-lipoxygenase activity
 xref: EC:;   MetaCyc:ARACHIDONATE-5-LIPOXYGENASE-RXN;   RHEA:32307;   reactome:R-HSA-265296 "Arachidonic acid is oxidised to 5S-HpETE by ALOX5";   reactome:R-HSA-266051 "5S-HpETE is dehydrated to LTA4 by ALOX5";   reactome:R-HSA-9018858 "ALOX5 oxidises 18(S)-HEPE to 5(S)-Hp-18(S)-HEPE";   reactome:R-HSA-9018859 "ALOX5 oxidises 5(S)-Hp-18(S)-HEPE to 5S,6S-epoxy-18(S)-HEPE";   reactome:R-HSA-9018863 "ALOX5 oxidises 18(R)-HEPE to 5(S)-Hp-18(R)-HEPE";   reactome:R-HSA-9018894 "ALOX5 oxidises 5(S)-Hp-18(R)-HEPE to 5S,6S-epoxy-18(R)-HEPE";   reactome:R-HSA-9020251 "ALOX5 oxidises 17(R)-HDHA to 7(S)-Hp-17(R)-HDHA";   reactome:R-HSA-9020255 "ALOX5 dehydrogenates 7(S)-Hp-17(S)-HDHA to 7S(8)-epoxy-17S-HDHA";   reactome:R-HSA-9020256 "ALOX5 dehydrogenates 7(S)-Hp-17R-HDHA to 7S(8)-epoxy-17R-HDHA";   reactome:R-HSA-9020259 "ALOX5 oxidises 17(R)-HDHA to 4(S)-Hp-17(R)-HDHA";   reactome:R-HSA-9020264 "ALOX5 oxidises 17(S)-HDHA to 4(S)-Hp-17(S)-HDHA";   reactome:R-HSA-9020277 "ALOX5 dehydrogenates 4(S)-Hp-17(S)-HDHA to 4S(5)-epoxy-17(S)-HDHA";   reactome:R-HSA-9020278 "ALOX5 dehydrogenates 4(S)-Hp-17(R)-HDHA to 4S(5)-epoxy-17(R)-HDHA";   reactome:R-HSA-9020282 "ALOX5 oxidises 17(S)-HDHA to 7(S)-Hp-17(S)-HDHA";   reactome:R-HSA-9024997 "ALOX5 oxidises 14(S)-Hp-DHA to 7(S),14(S)-diHp-DHA";   reactome:R-HSA-9025995 "ALOX5 dehydrogenates 7,17-diHp-DPAn-3 to 7,8-epoxy,17-HDPAn-3";   reactome:R-HSA-9025996 "ALOX5 oxidises 17(S)-Hp-DPAn-3 to 7,17-diHp-DPAn-3";   reactome:R-HSA-9025999 "ALOX5 dehydrogenates 17(S)-Hp-DPAn-3 to 16(S),17(S)-epoxy-DPAn-3";   reactome:R-HSA-9026005 "ALOX5 oxidises 14(S)-Hp-DPAn-3 to MaR3n-3 DPA";   reactome:R-HSA-9026405 "ALOX5 oxidises 13(R)-HDPAn-3 to RvT1-4";   reactome:R-HSA-9027624 "ALOX5 oxidises DHA to 7-HDHA";   reactome:R-HSA-9027628 "ALOX5 oxidises EPA to 5-HEPE";   reactome:R-HSA-9027633 "ALOX5 oxidises DPAn-3 to 7-HDPAn-3"

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arachidonate 5-lipoxygenase activity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Alox5 arachidonate 5-lipoxygenase JBrowse link 4 148,398,004 148,446,308 RGD:1600115
G Alox5ap arachidonate 5-lipoxygenase activating protein JBrowse link 12 6,854,930 6,879,112 RGD:69749

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  molecular_function 19678
    catalytic activity 6023
      oxidoreductase activity 848
        dioxygenase activity 79
          oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen 27
            arachidonate 5-lipoxygenase activity 2
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.