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Term:arachidonate 12(S)-lipoxygenase activity
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Accession:GO:0004052 term browser browse the term
Definition:Catalysis of the reaction: arachidonate + O(2) = (5Z,8Z,10E,12S,14Z)-12-hydroperoxyicosa-5,8,10,14-tetraenoate.
Synonyms:exact_synonym: 12Delta-lipoxygenase activity;   12S-lipoxygenase activity;   C-12 lipoxygenase activity;   LTA4 synthase activity;   arachidonate:oxygen 12-oxidoreductase activity;   delta12-lipoxygenase activity
 broad_synonym: leukotriene A4 synthase
 related_synonym: 12-lipoxygenase activity
 xref: EC:;   KEGG_REACTION:R01596;   MetaCyc:ARACHIDONATE-12-LIPOXYGENASE-RXN;   RHEA:10428;   reactome:R-HSA-2161948 "Arachidonic acid is converted to 12-oxoETE by ALOX12";   reactome:R-HSA-2161950 "Arachidonic acid is oxidised to 12R-HpETE by ALOX12B";   reactome:R-HSA-2161964 "Arachidonic acid is oxidised to 12S-HpETE by ALOX12/15";   reactome:R-HSA-9024983 "ALOX12:Fe2+ dehydrogenates 14(S)-Hp-DHA to 13(S),14(S)-epoxy-DHA";   reactome:R-HSA-9025957 "ALOX12:Fe2+ oxidises DPAn-6 to 14(S)-HDPAn-6";   reactome:R-HSA-9026006 "ALOX12:Fe2+ oxidises DPAn-3 to 14(S)-Hp-DPAn-3";   reactome:R-HSA-9026007 "ALOX12:Fe2+ dehydrogenates 14(S)-Hp-DPAn-3 to 13,14-epoxy-DPAn-3"

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arachidonate 12(S)-lipoxygenase activity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Alox12 arachidonate 12-lipoxygenase, 12S type JBrowse link 10 56,851,734 56,864,049 RGD:1600115
G Alox12b arachidonate 12-lipoxygenase, 12R type JBrowse link 10 55,744,646 55,756,524 RGD:1600115
G Alox12e arachidonate 12-lipoxygenase, epidermal JBrowse link 10 56,927,676 56,935,141 RGD:1600115
G Alox15 arachidonate 15-lipoxygenase JBrowse link 10 56,953,692 56,962,145 RGD:70288

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  molecular_function 19678
    catalytic activity 6023
      oxidoreductase activity 848
        dioxygenase activity 79
          oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen 27
            arachidonate 12(S)-lipoxygenase activity 4
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.