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ONTOLOGY REPORT - ANNOTATIONS


Term:cyclic-nucleotide phosphodiesterase activity
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Accession:GO:0004112 term browser browse the term
Definition:Catalysis of the reaction: a nucleoside cyclic phosphate + H2O = a nucleoside phosphate.


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cyclic-nucleotide phosphodiesterase activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pde10a phosphodiesterase 10A IDA RGD PMID:10583409, PMID:14604994 RGD:68285, RGD:2312517 NCBI chr 1:52,360,296...52,544,448
Ensembl chr 1:52,360,296...52,544,450
JBrowse link
G Pde11a phosphodiesterase 11A IDA RGD PMID:11502204 RGD:633590 NCBI chr 3:62,818,502...63,211,843
Ensembl chr 3:62,818,502...63,211,845
JBrowse link
G Pde11a_v1 phosphodiesterase 11A, variant 1 IDA RGD PMID:11502204 RGD:633590
G Pde11a_v2 phosphodiesterase 11A, variant 2 IDA RGD PMID:11502204 RGD:633590
G Pde11a_v3 phosphodiesterase 11A, variant 3 IDA RGD PMID:11502204 RGD:633590
G Pde1b phosphodiesterase 1B IDA RGD PMID:1326532 RGD:633601 NCBI chr 7:145,117,951...145,147,711
Ensembl chr 7:145,117,951...145,145,376
JBrowse link
G Pde3a phosphodiesterase 3A TAS RGD PMID:11673261 RGD:731220 NCBI chr 4:175,431,904...175,703,844
Ensembl chr 4:175,431,904...175,700,238
JBrowse link
G Pde4d phosphodiesterase 4D IDA RGD PMID:12834813 RGD:633641 NCBI chr 2:40,219,999...41,468,551
Ensembl chr 2:40,554,146...41,464,264
JBrowse link
G Pde5a phosphodiesterase 5A ISO (MGI:2450821|PMID:12554648) RGD PMID:12554648 MGI:2450821 NCBI chr 2:226,899,604...227,044,916
Ensembl chr 2:226,900,619...227,041,576
JBrowse link
G Pde7a phosphodiesterase 7A IMP RGD PMID:17010967 RGD:2312520 NCBI chr 2:104,042,124...104,134,101
Ensembl chr 2:104,045,811...104,134,101
JBrowse link
2',3'-cyclic-nucleotide 2'-phosphodiesterase activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adprm ADP-ribose/CDP-alcohol diphosphatase, manganese-dependent IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr10:53,583,275...53,595,821
Ensembl chr10:53,583,276...53,595,827
JBrowse link
2',3'-cyclic-nucleotide 3'-phosphodiesterase activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cnp 2',3'-cyclic nucleotide 3' phosphodiesterase TAS
ISO
IBA
IDA
(MGI:3050897|PMID:12590258)
PMID:21873635
RGD PMID:12590258, PMID:11842207, PMID:21873635, PMID:19357238 MGI:3050897, RGD:1298767, RGD:13792537, RGD:6480491 NCBI chr10:88,490,798...88,497,357
Ensembl chr10:88,490,798...88,497,356
JBrowse link
3',5'-cyclic-AMP phosphodiesterase activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pde1b phosphodiesterase 1B ISO (PMID:14687666) RGD PMID:14687666 NCBI chr 7:145,117,951...145,147,711
Ensembl chr 7:145,117,951...145,145,376
JBrowse link
G Pde2a phosphodiesterase 2A ISS
ISO
IBA
IEA
GO_REF:0000024
(MGI:5294502|PMID:21724846)
PMID:21873635
(PMID:14687666), (PMID:15938621)
GO_REF:0000107
UniProt
RGD
Ensembl
PMID:14687666, PMID:15938621, PMID:21724846, PMID:21873635 GO_REF:0000024, GO_REF:0000107, MGI:5294502, RGD:13792537 NCBI chr 1:166,534,643...166,626,158
Ensembl chr 1:166,534,643...166,626,158
JBrowse link
G Pde3a phosphodiesterase 3A IBA
ISO
PMID:21873635
(MGI:2136575|PMID:11420239)
RGD PMID:11420239, PMID:21873635 MGI:2136575, RGD:13792537 NCBI chr 4:175,431,904...175,703,844
Ensembl chr 4:175,431,904...175,700,238
JBrowse link
G Pde3b phosphodiesterase 3B IDA
IBA
PMID:21873635 RGD
GO_Central
PMID:12169692, PMID:21873635 RGD:729537, RGD:13792537 NCBI chr 1:183,892,841...184,078,071
Ensembl chr 1:183,892,841...184,078,071
JBrowse link
G Pde4a phosphodiesterase 4A IEA
ISO
IBA
GO_REF:0000107
(MGI:5286798|PMID:21670503)
PMID:21873635
UniProtKB:P06776|UniProtKB:P22434 (PMID:17404263), (PMID:8413254)
Ensembl
RGD
PMID:8413254, PMID:17404263, PMID:21670503, PMID:21873635 GO_REF:0000107, MGI:5286798, RGD:13792537 NCBI chr 8:22,189,533...22,234,036
Ensembl chr 8:22,189,600...22,233,748
JBrowse link
G Pde4b phosphodiesterase 4B IDA
ISO
IEA
IBA
(MGI:5286798|PMID:21670503)
GO_REF:0000002
GO_REF:0000107
PMID:21873635
UniProtKB:P06776|UniProtKB:P22434 (PMID:17404263), (PMID:8413254)
RGD
InterPro
Ensembl
PMID:8413254, PMID:17404263, PMID:21670503, PMID:12441002, PMID:21873635 GO_REF:0000002, GO_REF:0000107, MGI:5286798, RGD:633623, RGD:13792537 NCBI chr 5:121,759,236...122,136,814
Ensembl chr 5:121,952,977...122,136,814
JBrowse link
G Pde4c phosphodiesterase 4C IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr16:20,442,305...20,466,386
Ensembl chr16:20,442,609...20,460,959
Ensembl chr16:20,442,609...20,460,959
JBrowse link
G Pde4d phosphodiesterase 4D IEA
ISO
IBA
GO_REF:0000107
(MGI:5286798|PMID:21670503)
PMID:21873635
UniProtKB:P06776|UniProtKB:P22434 (PMID:12121997), (PMID:17404263), (PMID:20819076), (PMID:8413254), (PMID:9371713)
Ensembl
RGD
PMID:8413254, PMID:9371713, PMID:12121997, PMID:17404263, PMID:20819076, PMID:21670503, PMID:21873635 GO_REF:0000107, MGI:5286798, RGD:13792537 NCBI chr 2:40,219,999...41,468,551
Ensembl chr 2:40,554,146...41,464,264
JBrowse link
G Pde7a phosphodiesterase 7A TAS
IBA
IEA
ISO
PMID:21873635
GO_REF:0000107
(PMID:8943082)
Ensembl
RGD
PMID:8943082, PMID:11304758, PMID:21873635 GO_REF:0000107, RGD:731232, RGD:13792537 NCBI chr 2:104,042,124...104,134,101
Ensembl chr 2:104,045,811...104,134,101
JBrowse link
G Pde7b phosphodiesterase 7B IDA
ISO
IBA
(MGI:1859049|PMID:10872825)
PMID:21873635
RGD PMID:10872825, PMID:11772393, PMID:21873635 MGI:1859049, RGD:625534, RGD:13792537 NCBI chr 1:15,889,845...16,203,909
Ensembl chr 1:15,893,533...16,203,909
JBrowse link
G Pde7b_v3 phosphodiesterase 7B, variant 3 IDA RGD PMID:11772393 RGD:625534
G Pde8a phosphodiesterase 8A ISO
IBA
(PMID:9618252)
(MGI:1276230|PMID:9671792)
PMID:21873635
RGD PMID:9618252, PMID:9671792, PMID:21873635 MGI:1276230, RGD:13792537 NCBI chr 1:143,036,083...143,160,395
Ensembl chr 1:143,036,218...143,159,433
JBrowse link
G Pde8b phosphodiesterase 8B ISO
IBA
(PMID:9784418)
(MGI:5526088|PMID:21187369)
PMID:21873635
RGD PMID:9784418, PMID:21187369, PMID:21873635 MGI:5526088, RGD:13792537 NCBI chr 2:24,718,548...24,955,533
Ensembl chr 2:24,719,976...24,923,128
JBrowse link
3',5'-cyclic-GMP phosphodiesterase activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pde10a phosphodiesterase 10A IEA GO_REF:0000003 UniProt GO_REF:0000003 NCBI chr 1:52,360,296...52,544,448
Ensembl chr 1:52,360,296...52,544,450
JBrowse link
G Pde11a phosphodiesterase 11A IEA GO_REF:0000003 UniProt GO_REF:0000003 NCBI chr 3:62,818,502...63,211,843
Ensembl chr 3:62,818,502...63,211,845
JBrowse link
G Pde11a_v3 phosphodiesterase 11A, variant 3 IEA GO_REF:0000003 UniProt GO_REF:0000003
G Pde1b phosphodiesterase 1B ISO (PMID:14687666) RGD PMID:14687666 NCBI chr 7:145,117,951...145,147,711
Ensembl chr 7:145,117,951...145,145,376
JBrowse link
G Pde2a phosphodiesterase 2A IEA
ISO
IBA
GO_REF:0000107
(MGI:5294502|PMID:21724846)
PMID:21873635
(PMID:14687666), (PMID:15938621)
Ensembl
RGD
PMID:14687666, PMID:15938621, PMID:21724846, PMID:21873635 GO_REF:0000107, MGI:5294502, RGD:13792537 NCBI chr 1:166,534,643...166,626,158
Ensembl chr 1:166,534,643...166,626,158
JBrowse link
G Pde5a phosphodiesterase 5A TAS
IBA
ISO
IEA
IDA
PMID:21873635
(PMID:14687666)
GO_REF:0000107
RGD
Ensembl
PMID:14687666, PMID:9370351, PMID:21873635, PMID:15623434, PMID:15100365 GO_REF:0000107, RGD:729513, RGD:13792537, RGD:1582533, RGD:1582531 NCBI chr 2:226,899,604...227,044,916
Ensembl chr 2:226,900,619...227,041,576
JBrowse link
G Pde6a phosphodiesterase 6A IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr18:56,544,652...56,617,480
Ensembl chr18:56,544,652...56,617,480
JBrowse link
G Pde6g phosphodiesterase 6G IEA GO_REF:0000003 UniProt GO_REF:0000003 NCBI chr10:109,620,499...109,625,214
Ensembl chr10:109,620,980...109,622,745
JBrowse link
G Pde6h phosphodiesterase 6H IEA GO_REF:0000003 UniProt GO_REF:0000003 NCBI chr 4:170,947,723...170,963,046
Ensembl chr 4:170,958,196...170,963,046
JBrowse link
G Pde8a phosphodiesterase 8A ISO (PMID:9618252) RGD PMID:9618252 NCBI chr 1:143,036,083...143,160,395
Ensembl chr 1:143,036,218...143,159,433
JBrowse link
G Pde9a phosphodiesterase 9A IDA
ISO
IBA
(MGI:1266874|PMID:9624145)
PMID:21873635
(PMID:25799991), (PMID:9624146)
RGD PMID:9624145, PMID:9624146, PMID:25799991, PMID:14501210, PMID:21873635 MGI:1266874, RGD:724613, RGD:13792537 NCBI chr20:10,123,624...10,216,325
Ensembl chr20:10,123,651...10,216,548
JBrowse link
3',5'-cyclic-nucleotide phosphodiesterase activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pde10a phosphodiesterase 10A IEA
ISO
IBA
GO_REF:0000002
(MGI:1339115|PMID:10359840), (MGI:5775673|PMID:27058446)
PMID:21873635
InterPro
RGD
PMID:10359840, PMID:27058446, PMID:21873635 GO_REF:0000002, MGI:1339115, MGI:5775673, RGD:13792537 NCBI chr 1:52,360,296...52,544,448
Ensembl chr 1:52,360,296...52,544,450
JBrowse link
G Pde11a phosphodiesterase 11A IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 3:62,818,502...63,211,843
Ensembl chr 3:62,818,502...63,211,845
JBrowse link
G Pde11a_v3 phosphodiesterase 11A, variant 3 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537
G Pde1a phosphodiesterase 1A IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 3:66,803,247...67,263,658
Ensembl chr 3:66,803,247...66,885,094
JBrowse link
G Pde1b phosphodiesterase 1B IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 7:145,117,951...145,147,711
Ensembl chr 7:145,117,951...145,145,376
JBrowse link
G Pde1c phosphodiesterase 1C IEA
IBA
GO_REF:0000002
PMID:21873635
InterPro PMID:21873635 GO_REF:0000002, RGD:13792537 NCBI chr 4:86,359,762...86,925,044
Ensembl chr 4:86,359,820...86,630,543
JBrowse link
G Pde2a phosphodiesterase 2A IEA
IBA
GO_REF:0000002
PMID:21873635
InterPro PMID:21873635 GO_REF:0000002, RGD:13792537 NCBI chr 1:166,534,643...166,626,158
Ensembl chr 1:166,534,643...166,626,158
JBrowse link
G Pde3a phosphodiesterase 3A IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 4:175,431,904...175,703,844
Ensembl chr 4:175,431,904...175,700,238
JBrowse link
G Pde3b phosphodiesterase 3B IEA
IBA
ISO
GO_REF:0000002
PMID:21873635
(PMID:8562305), (PMID:9102399)
InterPro
RGD
PMID:8562305, PMID:9102399, PMID:21873635 GO_REF:0000002, RGD:13792537 NCBI chr 1:183,892,841...184,078,071
Ensembl chr 1:183,892,841...184,078,071
JBrowse link
G Pde4a phosphodiesterase 4A IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 8:22,189,533...22,234,036
Ensembl chr 8:22,189,600...22,233,748
JBrowse link
G Pde4b phosphodiesterase 4B IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 5:121,759,236...122,136,814
Ensembl chr 5:121,952,977...122,136,814
JBrowse link
G Pde4c phosphodiesterase 4C IEA
IBA
GO_REF:0000002
PMID:21873635
InterPro PMID:21873635 GO_REF:0000002, RGD:13792537 NCBI chr16:20,442,305...20,466,386
Ensembl chr16:20,442,609...20,460,959
Ensembl chr16:20,442,609...20,460,959
JBrowse link
G Pde4d phosphodiesterase 4D IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 2:40,219,999...41,468,551
Ensembl chr 2:40,554,146...41,464,264
JBrowse link
G Pde5a phosphodiesterase 5A IBA
ISO
PMID:21873635
(MGI:4361111|PMID:19474061)
RGD PMID:19474061, PMID:21873635 MGI:4361111, RGD:13792537 NCBI chr 2:226,899,604...227,044,916
Ensembl chr 2:226,900,619...227,041,576
JBrowse link
G Pde6a phosphodiesterase 6A IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr18:56,544,652...56,617,480
Ensembl chr18:56,544,652...56,617,480
JBrowse link
G Pde6b phosphodiesterase 6B IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr14:2,328,690...2,371,913
Ensembl chr14:2,328,750...2,371,883
JBrowse link
G Pde6c phosphodiesterase 6C IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 1:256,822,099...256,885,879
Ensembl chr 1:256,822,334...256,877,810
JBrowse link
G Pde6d phosphodiesterase 6D IEA GO_REF:0000104 UniProt GO_REF:0000104 NCBI chr 9:93,562,099...93,607,061
Ensembl chr 9:93,562,095...93,607,087
JBrowse link
G Pde7a phosphodiesterase 7A IEA
IBA
GO_REF:0000002
PMID:21873635
InterPro PMID:21873635 GO_REF:0000002, RGD:13792537 NCBI chr 2:104,042,124...104,134,101
Ensembl chr 2:104,045,811...104,134,101
JBrowse link
G Pde7b phosphodiesterase 7B IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 1:15,889,845...16,203,909
Ensembl chr 1:15,893,533...16,203,909
JBrowse link
G Pde8a phosphodiesterase 8A IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 1:143,036,083...143,160,395
Ensembl chr 1:143,036,218...143,159,433
JBrowse link
G Pde8b phosphodiesterase 8B IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 2:24,718,548...24,955,533
Ensembl chr 2:24,719,976...24,923,128
JBrowse link
G Pde9a phosphodiesterase 9A IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr20:10,123,624...10,216,325
Ensembl chr20:10,123,651...10,216,548
JBrowse link
calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pde1a phosphodiesterase 1A IMP
ISO
IBA
(MGI:6355909|PMID:15901640)
PMID:21873635
RGD PMID:15901640, PMID:16514069, PMID:21873635 MGI:6355909, RGD:2312521, RGD:13792537 NCBI chr 3:66,803,247...67,263,658
Ensembl chr 3:66,803,247...66,885,094
JBrowse link
G Pde1b phosphodiesterase 1B IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 7:145,117,951...145,147,711
Ensembl chr 7:145,117,951...145,145,376
JBrowse link
G Pde1c phosphodiesterase 1C IDA
IBA
PMID:7568196
PMID:21873635
MGI
GO_Central
PMID:7568196, PMID:21873635 RGD:68318, RGD:13792537 NCBI chr 4:86,359,762...86,925,044
Ensembl chr 4:86,359,820...86,630,543
JBrowse link
calmodulin-dependent cyclic-nucleotide phosphodiesterase activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pde1c phosphodiesterase 1C IDA RGD PMID:7568196 RGD:68318 NCBI chr 4:86,359,762...86,925,044
Ensembl chr 4:86,359,820...86,630,543
JBrowse link
cGMP-stimulated cyclic-nucleotide phosphodiesterase activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pde10a phosphodiesterase 10A ISO
IBA
ISS
(PMID:19689430)
PMID:21873635
GO_REF:0000024
RGD
UniProt
PMID:19689430, PMID:21873635, PMID:19689430 GO_REF:0000024, RGD:13792537, RGD:12790642 NCBI chr 1:52,360,296...52,544,448
Ensembl chr 1:52,360,296...52,544,450
JBrowse link
G Pde11a phosphodiesterase 11A ISO
IBA
ISS
(PMID:19689430)
PMID:21873635
GO_REF:0000024
RGD
UniProt
PMID:19689430, PMID:21873635 GO_REF:0000024, RGD:13792537 NCBI chr 3:62,818,502...63,211,843
Ensembl chr 3:62,818,502...63,211,845
JBrowse link
G Pde11a_v3 phosphodiesterase 11A, variant 3 ISS
IBA
GO_REF:0000024
PMID:21873635
UniProt PMID:21873635 GO_REF:0000024, RGD:13792537
G Pde2a phosphodiesterase 2A IEA
ISO
IBA
GO_REF:0000107
(MGI:5294304|PMID:15210692)
PMID:21873635
(PMID:17329248), (PMID:19689430)
Ensembl
RGD
PMID:15210692, PMID:17329248, PMID:19689430, PMID:21873635 GO_REF:0000107, MGI:5294304, RGD:13792537 NCBI chr 1:166,534,643...166,626,158
Ensembl chr 1:166,534,643...166,626,158
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  molecular_function 20457
    catalytic activity 6065
      hydrolase activity 2637
        hydrolase activity, acting on ester bonds 804
          phosphoric ester hydrolase activity 377
            phosphoric diester hydrolase activity 90
              cyclic-nucleotide phosphodiesterase activity 30
                2',3'-cyclic-nucleotide 2'-phosphodiesterase activity 1
                2',3'-cyclic-nucleotide 3'-phosphodiesterase activity 1
                3',5'-cyclic-nucleotide phosphodiesterase activity + 26
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.