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ONTOLOGY REPORT - ANNOTATIONS


Term:threonine-type endopeptidase activity
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Accession:GO:0004298 term browser browse the term
Definition:Catalysis of the hydrolysis of internal peptide bonds in a polypeptide chain by a mechanism in which the hydroxyl group of a threonine residue at the active center acts as a nucleophile.
Synonyms:exact_synonym: threonine endopeptidase activity
 narrow_synonym: large multicatalytic protease;   lens neutral proteinase;   multicatalytic proteinase;   multicatalytic proteinase (complex);   proteasome endopeptidase complex;   tricorn protease;   tricorn proteinase
 related_synonym: 26S protease;   MCP;   alkaline protease;   ingensin;   multicatalytic endopeptidase complex;   prosome
 xref: EC:3.4.25


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threonine-type endopeptidase activity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G H AC018523.2 novel protein RGD:2290271
G R LOC100360846 proteasome subunit beta type 6-like JBrowse link 2 96,031,967 96,033,538 RGD:1600115
G D LOC102152879 proteasome subunit alpha type-1-like JBrowse link 30 24,114,023 24,116,951 RGD:13508589
G P PRORP protein only RNase P catalytic subunit JBrowse link 7 64,620,514 64,763,272 RGD:14298760
G M Prss50 serine protease 50 RGD:9068941
G V PRSS50 serine protease 50 JBrowse link 22 8,135,011 8,142,455 RGD:9068941
G P PRSS50 serine protease 50 JBrowse link 13 29,633,575 29,638,994 RGD:9068941
G S Prss50 serine protease 50 JBrowse link NW_004936596 541,918 544,866 RGD:9068941
G D PRSS50 serine protease 50 JBrowse link 20 42,046,177 42,051,517 RGD:13508589
G B PRSS50 serine protease 50 JBrowse link 3 46,610,119 46,616,435 RGD:9068941
G C Prss50 serine protease 50 JBrowse link NW_004955420 25,424,082 25,427,705 RGD:9068941
G R Prss50 serine protease 50 JBrowse link 8 119,134,966 119,141,255 RGD:1624291
RGD:13792537
G M Prss50 protease, serine 50 JBrowse link 9 110,857,964 110,864,629 RGD:2290270
G H PRSS50 serine protease 50 JBrowse link 3 46,712,117 46,717,869 RGD:2290271
G P PSMA1 proteasome 20S subunit alpha 1 JBrowse link 2 44,740,102 44,755,296 RGD:14298760
G D PSMA1 proteasome 20S subunit alpha 1 JBrowse link 21 37,230,253 37,243,356 RGD:13508589
G R Psma1 proteasome 20S subunit alpha 1 JBrowse link 1 183,733,567 183,744,586 RGD:1600115
G M Psma1 proteasome subunit alpha 1 JBrowse link 7 114,264,550 114,276,116 RGD:2290270
G H PSMA1 proteasome 20S subunit alpha 1 JBrowse link 11 14,504,876 14,643,634 RGD:2290271
G P PSMA2 proteasome 20S subunit alpha 2 JBrowse link 18 51,909,399 51,919,859 RGD:14298760
G D PSMA2 proteasome 20S subunit alpha 2 JBrowse link 18 7,218,150 7,228,859 RGD:13508589
G R Psma2 proteasome 20S subunit alpha 2 JBrowse link 17 53,091,937 53,102,324 RGD:1600115
G M Psma2 proteasome subunit alpha 2 JBrowse link 13 14,613,242 14,625,673 RGD:2290270
G H PSMA2 proteasome 20S subunit alpha 2 JBrowse link 7 42,916,861 42,932,174 RGD:2290271
G P PSMA3 proteasome 20S subunit alpha 3 JBrowse link 1 187,342,231 187,371,149 RGD:14298760
G D PSMA3 proteasome 20S subunit alpha 3 JBrowse link 8 33,616,735 33,642,434 RGD:13508589
G R Psma3 proteasome 20S subunit alpha 3 JBrowse link 6 93,423,029 93,444,223 RGD:1600115
G M Psma3 proteasome subunit alpha 3 JBrowse link 12 70,969,283 70,995,877 RGD:2290270
G H PSMA3 proteasome 20S subunit alpha 3 JBrowse link 14 58,244,805 58,272,009 RGD:2290271
G R Psma3l proteasome subunit alpha type 3-like RGD:1600115
G P PSMA4 proteasome 20S subunit alpha 4 JBrowse link 7 47,440,576 47,448,599 RGD:14298760
G R Psma4 proteasome 20S subunit alpha 4 JBrowse link 8 59,532,456 59,539,916 RGD:1600115
G M Psma4 proteasome subunit alpha 4 JBrowse link 9 54,950,781 54,958,034 RGD:2290270
G H PSMA4 proteasome 20S subunit alpha 4 JBrowse link 15 78,540,405 78,552,417 RGD:2290271
G P PSMA5 proteasome 20S subunit alpha 5 JBrowse link 4 110,695,429 110,717,308 RGD:14298760
G D PSMA5 proteasome 20S subunit alpha 5 JBrowse link 6 42,425,590 42,450,074 RGD:13508589
G R Psma5 proteasome 20S subunit alpha 5 JBrowse link 2 211,050,344 211,073,706 RGD:1600115
G M Psma5 proteasome subunit alpha 5 JBrowse link 3 108,256,926 108,279,952 RGD:2290270
G H PSMA5 proteasome 20S subunit alpha 5 JBrowse link 1 109,399,042 109,426,448 RGD:2290271
G P PSMA6 proteasome 20S subunit alpha 6 JBrowse link 7 64,578,247 64,603,351 RGD:14298760
G D PSMA6 proteasome 20S subunit alpha 6 JBrowse link 8 14,010,899 14,038,141 RGD:13508589
G R Psma6 proteasome 20S subunit alpha 6 JBrowse link 6 76,174,460 76,205,429 RGD:1600115
G M Psma6 proteasome subunit alpha 6 JBrowse link 12 55,384,222 55,418,459 RGD:2290270
G H PSMA6 proteasome 20S subunit alpha 6 JBrowse link 14 35,278,558 35,317,493 RGD:2290271
G P PSMA7 proteasome 20S subunit alpha 7 JBrowse link 17 61,566,373 61,571,516 RGD:14298760
G D PSMA7 proteasome 20S subunit alpha 7 JBrowse link 24 46,182,344 46,186,241 RGD:13508589
G R Psma7 proteasome 20S subunit alpha 7 JBrowse link 3 175,420,042 175,426,384 RGD:1600115
G M Psma7 proteasome subunit alpha 7 JBrowse link 2 180,036,367 180,042,464 RGD:2290270
G H PSMA7 proteasome 20S subunit alpha 7 JBrowse link 20 62,136,733 62,143,394 RGD:2290271
G P PSMA8 proteasome 20S subunit alpha 8 JBrowse link 6 110,799,065 110,836,937 RGD:14298760
G D PSMA8 proteasome 20S subunit alpha 8 JBrowse link 7 62,432,477 62,472,984 RGD:13508589
G R Psma8 proteasome 20S subunit alpha 8 JBrowse link 18 6,114,757 6,182,393 RGD:1600115
G M Psma8 proteasome subunit alpha 8 JBrowse link 18 14,706,135 14,762,301 RGD:2290270
G H PSMA8 proteasome 20S subunit alpha 8 JBrowse link 18 26,133,869 26,193,355 RGD:2290271
G P PSMB1 proteasome 20S subunit beta 1 JBrowse link 1 23,827 40,033 RGD:14298760
G D PSMB1 proteasome 20S subunit beta 1 JBrowse link 12 72,440,224 72,456,304 RGD:13508589
G R Psmb1 proteasome 20S subunit beta 1 JBrowse link 1 57,470,878 57,491,359 RGD:1600115
G M Psmb1 proteasome (prosome, macropain) subunit, beta type 1 JBrowse link 17 15,475,721 15,498,276 RGD:2290270
G H PSMB1 proteasome 20S subunit beta 1 JBrowse link 6 170,535,120 170,553,307 RGD:2290271
G P PSMB10 proteasome 20S subunit beta 10 JBrowse link 6 28,544,910 28,547,609 RGD:14298760
G D PSMB10 proteasome 20S subunit beta 10 JBrowse link 5 81,560,750 81,563,571 RGD:13508589
G R Psmb10 proteasome 20S subunit beta 10 JBrowse link 19 37,909,543 37,912,027 RGD:1600115
G M Psmb10 proteasome (prosome, macropain) subunit, beta type 10 JBrowse link 8 105,935,728 105,938,392 RGD:2290270
G H PSMB10 proteasome 20S subunit beta 10 JBrowse link 16 67,934,506 67,936,850 RGD:2290271
G P PSMB11 proteasome subunit beta 11 JBrowse link 7 76,005,609 76,006,728 RGD:14298760
G R Psmb11 proteasome subunit beta 11 JBrowse link 15 33,267,413 33,273,587 RGD:1600115
G M Psmb11 proteasome (prosome, macropain) subunit, beta type, 11 JBrowse link 14 54,625,310 54,629,556 RGD:2290270
G H PSMB11 proteasome subunit beta 11 JBrowse link 14 23,042,212 23,044,060 RGD:2290271
G P PSMB2 proteasome 20S subunit beta 2 JBrowse link 6 91,792,055 91,829,942 RGD:14298760
G D PSMB2 proteasome 20S subunit beta 2 JBrowse link 15 6,511,281 6,544,859 RGD:13508589
G R Psmb2 proteasome 20S subunit beta 2 JBrowse link 5 144,702,004 144,734,220 RGD:1600115
G M Psmb2 proteasome (prosome, macropain) subunit, beta type 2 JBrowse link 4 126,677,637 126,709,715 RGD:2290270
G H PSMB2 proteasome 20S subunit beta 2 JBrowse link 1 35,599,541 35,641,526 RGD:2290271
G P PSMB3 proteasome 20S subunit beta 3 JBrowse link 12 23,347,060 23,357,616 RGD:14298760
G D PSMB3 proteasome 20S subunit beta 3 JBrowse link 9 23,474,476 23,484,408 RGD:13508589
G R Psmb3 proteasome 20S subunit beta 3 JBrowse link 10 85,646,646 85,653,729 RGD:1600115
G M Psmb3 proteasome (prosome, macropain) subunit, beta type 3 JBrowse link 11 97,703,434 97,713,500 RGD:2290270
G H PSMB3 proteasome 20S subunit beta 3 JBrowse link 17 38,752,741 38,764,225 RGD:2290271
G P PSMB4 proteasome 20S subunit beta 4 JBrowse link 4 97,835,544 97,837,909 RGD:14298760
G D PSMB4 proteasome 20S subunit beta 4 JBrowse link 17 60,461,208 60,463,604 RGD:13508589
G R Psmb4 proteasome 20S subunit beta 4 JBrowse link 2 196,043,546 196,046,320 RGD:1600115
G M Psmb4 proteasome (prosome, macropain) subunit, beta type 4 JBrowse link 3 94,884,324 94,886,958 RGD:2290270
G H PSMB4 proteasome 20S subunit beta 4 JBrowse link 1 151,399,573 151,401,937 RGD:2290271
G D PSMB5 proteasome 20S subunit beta 5 JBrowse link 8 3,344,157 3,349,921 RGD:13508589
G R Psmb5 proteasome 20S subunit beta 5 JBrowse link 15 33,259,039 33,263,634 RGD:1600115
G M Psmb5 proteasome (prosome, macropain) subunit, beta type 5 JBrowse link 14 54,614,120 54,617,995 RGD:2290270
G H PSMB5 proteasome 20S subunit beta 5 JBrowse link 14 23,025,851 23,035,220 RGD:2290271
G P PSMB6 proteasome 20S subunit beta 6 JBrowse link 12 52,096,009 52,098,164 RGD:14298760
G D PSMB6 proteasome 20S subunit beta 6 JBrowse link 5 31,776,286 31,778,789 RGD:13508589
G R Psmb6 proteasome 20S subunit beta 6 JBrowse link 10 57,131,339 57,133,685 RGD:1600115
G M Psmb6 proteasome (prosome, macropain) subunit, beta type 6 JBrowse link 11 70,525,324 70,527,858 RGD:2290270
G H PSMB6 proteasome 20S subunit beta 6 JBrowse link 17 4,796,144 4,798,503 RGD:2290271
G P PSMB7 proteasome 20S subunit beta 7 JBrowse link 1 265,172,257 265,235,389 RGD:14298760
G D PSMB7 proteasome 20S subunit beta 7 JBrowse link 9 58,529,646 58,593,016 RGD:13508589
G R Psmb7 proteasome 20S subunit beta 7 JBrowse link 3 22,890,072 22,951,718 RGD:1600115
G M Psmb7 proteasome (prosome, macropain) subunit, beta type 7 JBrowse link 2 38,588,046 38,643,952 RGD:2290270
G H PSMB7 proteasome 20S subunit beta 7 JBrowse link 9 124,353,465 124,415,442 RGD:2290271
G P PSMB8 proteasome 20S subunit beta 8 JBrowse link 7 25,058,456 25,061,666 RGD:14298760
G D PSMB8 proteasome 20S subunit beta 8 JBrowse link 12 2,419,456 2,422,832 RGD:13508589
G R Psmb8 proteasome 20S subunit beta 8 JBrowse link 20 3,990,809 3,993,772 RGD:1600115
G M Psmb8 proteasome (prosome, macropain) subunit, beta type 8 (large multifunctional peptidase 7) JBrowse link 17 34,198,195 34,201,454 RGD:2290270
G H PSMB8 proteasome 20S subunit beta 8 JBrowse link 6 32,840,717 32,844,679 RGD:2290271
G P PSMB9 proteasome 20S subunit beta 9 JBrowse link 7 25,072,133 25,077,508 RGD:14298760
G D PSMB9 proteasome 20S subunit beta 9 JBrowse link 12 2,432,287 2,438,920 RGD:13508589
G R Psmb9 proteasome 20S subunit beta 9 JBrowse link 20 3,973,424 3,978,845 RGD:1600115
G M Psmb9 proteasome (prosome, macropain) subunit, beta type 9 (large multifunctional peptidase 2) JBrowse link 17 34,182,030 34,187,330 RGD:2290270
G H PSMB9 proteasome 20S subunit beta 9 JBrowse link 6 32,854,192 32,859,851 RGD:2290271
G M Tasp1 taspase 1 RGD:9068941
G V TASP1 taspase 1 JBrowse link 2 42,284,264 42,529,551 RGD:9068941
G P TASP1 taspase 1 JBrowse link 17 21,963,369 22,358,444 RGD:14298760
G S Tasp1 taspase 1 JBrowse link NW_004936485 6,163,809 6,460,361 RGD:9068941
G D TASP1 taspase 1 JBrowse link 24 9,001,175 9,314,212 RGD:13508589
G B TASP1 taspase 1 JBrowse link 20 13,350,135 13,599,861 RGD:9068941
G C Tasp1 taspase 1 JBrowse link NW_004955415 22,856,382 23,091,732 RGD:9068941
G R Tasp1 taspase 1 JBrowse link 3 132,888,785 133,131,213 RGD:1624291
RGD:13792537
G M Tasp1 taspase, threonine aspartase 1 JBrowse link 2 139,833,479 140,066,847 RGD:2290270
G H TASP1 taspase 1 JBrowse link 20 13,104,760 13,638,936 RGD:2290271

Term paths to the root
Path 1
Term Annotations click to browse term
  molecular_function 138873
    catalytic activity 39356
      hydrolase activity 16527
        peptidase activity 4239
          endopeptidase activity 2752
            threonine-type endopeptidase activity 113
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.