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ONTOLOGY REPORT - ANNOTATIONS


Term:enoyl-CoA hydratase activity
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Accession:GO:0004300 term browser browse the term
Definition:Catalysis of the reaction: (3S)-3-hydroxyacyl-CoA = trans-2-enoyl-CoA + H2O.
Synonyms:exact_synonym: short-chain enoyl-CoA hydratase activity
 broad_synonym: D-3-hydroxyacyl-CoA dehydratase;   enoyl coenzyme A hydrase (D)
 related_synonym: (3S)-3-hydroxyacyl-CoA hydro-lyase activity;   2-enoyl-CoA hydratase activity;   2-octenoyl coenzyme A hydrase activity;   ECH;   acyl coenzyme A hydrase activity;   beta-hydroxyacid dehydrase activity;   beta-hydroxyacyl-CoA dehydrase activity;   crotonyl hydrase activity;   enol-CoA hydratase activity;   enoyl coenzyme A hydrase (L);   enoyl coenzyme A hydratase activity;   enoyl hydrase activity;   hydratase, enoyl coenzyme A;   short chain enoyl coenzyme A hydratase activity;   trans-2-enoyl-CoA hydratase activity;   unsaturated acyl-CoA hydratase activity
 alt_id: GO:0016510
 xref: EC:4.2.1.17;   MetaCyc:ENOYL-COA-HYDRAT-RXN;   RHEA:16105;   Reactome:R-HSA-70870 "ECHS1 hydrates methacrylyl-CoA";   UM-BBD_enzymeID:e0014;   reactome:R-HSA-70830 "tiglyl-CoA + H2O <=> alpha-methyl-beta-hydroxybutyryl-CoA";   reactome:R-HSA-77256 "2-trans-Dodecenoyl-CoA+H2O<=>(S)-3-Hydroxydodecanoyl-CoA";   reactome:R-HSA-77277 "trans-Tetradec-2-enoyl-CoA+H2O<=>(S)-3-Hydroxytetradecanoyl-CoA";   reactome:R-HSA-77301 "trans-Hexadec-2-enoyl-CoA+H2O<=>(S)-3-Hydroxyhexadecanoyl-CoA";   reactome:R-HSA-77314 "Crotonoyl-CoA+H2O<=>(S)-3-Hydroxybutanoyl-CoA";   reactome:R-HSA-77325 "trans-Hex-2-enoyl-CoA+H2O<=>(S)-Hydroxyhexanoyl-CoA";   reactome:R-HSA-77333 "trans-Oct-2-enoyl-CoA+H2O<=>(S)-Hydroxyoctanoyl-CoA";   reactome:R-HSA-77344 "trans-Dec-2-enoyl-CoA+H2O<=>(S)-Hydroxydecanoyl-CoA"


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enoyl-CoA hydratase activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Auh AU RNA binding methylglutaconyl-CoA hydratase ISO
IBA
(MGI:MGI:1332868|PMID:10072761)
PMID:21873635
(PMID:7892223)
RGD PMID:7892223, PMID:10072761, PMID:21873635 MGI:MGI:1332868, RGD:13792537 NCBI chr17:12,310,178...12,405,224
Ensembl chr17:12,310,214...12,405,205
JBrowse link
G Echdc1 ethylmalonyl-CoA decarboxylase 1 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 1:30,874,410...30,921,117
Ensembl chr 1:30,874,418...30,917,882
JBrowse link
G Echdc2 enoyl CoA hydratase domain containing 2 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 5:127,770,570...127,789,568
Ensembl chr 5:127,770,570...127,789,567
JBrowse link
G Echdc3 enoyl CoA hydratase domain containing 3 IMP PMID:11009615 UniProt PMID:11009615 RGD:30309943 NCBI chr17:76,002,304...76,022,813
Ensembl chr17:76,002,275...76,022,813
JBrowse link
G Echs1 enoyl-CoA hydratase, short chain 1 IDA
IBA
ISO
IMP
PMID:21873635
(PMID:26251176)
RGD PMID:26251176, PMID:7993901, PMID:21873635, PMID:12379132 RGD:2317611, RGD:13792537, RGD:2317616 NCBI chr 1:212,570,213...212,579,040
Ensembl chr 1:212,570,195...212,579,057
JBrowse link
G Eci1 enoyl-CoA delta isomerase 1 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr10:13,797,573...13,810,918
Ensembl chr10:13,797,562...13,810,913
JBrowse link
G Ehhadh enoyl-CoA hydratase and 3-hydroxyacyl CoA dehydrogenase IDA
ISO
PMID:12106015
(PMID:15060085)
RGD PMID:15060085, PMID:12106015 RGD:21201263 NCBI chr11:82,945,104...82,978,364
Ensembl chr11:82,945,104...82,978,364
JBrowse link
G Hadha hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha IMP
IBA
IDA
PMID:21873635 RGD
GO_Central
PMID:8253773, PMID:21873635, PMID:1730633 RGD:632874, RGD:13792537, RGD:1600572 NCBI chr 6:27,589,840...27,628,921
Ensembl chr 6:27,589,657...27,629,175
JBrowse link
G Hsd17b4 hydroxysteroid (17-beta) dehydrogenase 4 ISO
IBA
IEA
ISS
(PMID:10706581), (PMID:15060085), (PMID:9482850)
PMID:21873635
GO_REF:0000107
GO_REF:0000024
RGD
Ensembl
UniProt
PMID:9482850, PMID:10706581, PMID:15060085, PMID:21873635 GO_REF:0000024, GO_REF:0000107, RGD:13792537 NCBI chr18:44,810,462...44,897,677
Ensembl chr18:44,810,388...44,897,640
JBrowse link
G LOC100911186 enoyl-CoA hydratase, mitochondrial-like IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 1:141,821,909...141,830,770
Ensembl chr 1:141,821,916...141,830,764
JBrowse link

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Term Annotations click to browse term
  molecular_function 20457
    catalytic activity 6065
      lyase activity 212
        carbon-oxygen lyase activity 92
          hydro-lyase activity 71
            enoyl-CoA hydratase activity 10
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.