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ONTOLOGY REPORT - ANNOTATIONS


Term:histone acetyltransferase activity
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Accession:GO:0004402 term browser browse the term
Definition:Catalysis of the reaction: acetyl-CoA + histone = CoA + acetyl-histone.
Comment:Note that the term 'histone lysine acetyltransferase activity ; GO:0046971' was merged into this term because only lysine residues are ever acetylated in histones, and so the term was redundant.
Synonyms:exact_synonym: acetyl-CoA:histone acetyltransferase activity;   histone acetokinase activity;   histone acetylase activity;   histone lysine acetyltransferase activity;   histone transacetylase activity
 narrow_synonym: H2A/H2B histone acetyltransferase activity;   H3/H4 histone acetyltransferase activity;   H4/H2 histone acetyltransferase activity;   H4/H2A acetyltransferase activity
 related_synonym: nucleosome-histone acetyltransferase activity
 alt_id: GO:0004403;   GO:0004404;   GO:0004405;   GO:0004406;   GO:0043166;   GO:0046971
 xref: EC:2.3.1.48;   MetaCyc:HISTONE-ACETYLTRANSFERASE-RXN;   RHEA:21992;   reactome:R-HSA-3301237 "KAT2 complexes acetylate histone H3";   reactome:R-HSA-3301345 "Elongator complex acetylates replicative histone H3, H4";   reactome:R-HSA-3318413 "KAT7-containing ING4/5 complexes acetylate Me3K-histone H3";   reactome:R-HSA-3318415 "ATF2 acetylates histone H2B, H4";   reactome:R-HSA-3318486 "KAT6A, KAT6B-containing ING5 complexes acetylate replicative histone H3";   reactome:R-HSA-3321805 "NSL acetylates histone H4";   reactome:R-HSA-3321883 "MSL acetylates histone H4";   reactome:R-HSA-3321975 "NuA4 complex acetylates histone H2A, HIST1H4";   reactome:R-HSA-3451147 "KAT5 HAT complex acetylates TCF4 gene at histone H4";   reactome:R-HSA-3662318 "Type B histone acetlytransferase complex acetylates histone H4";   reactome:R-HSA-3662335 "EP300 acetylates histone H2A, H2B, H3, H4";   reactome:R-HSA-3697008 "CREBBP acetylates histone H2B, H3, H4";   reactome:R-HSA-3697920 "CLOCK acetylates lysine-10 of histone H3, H4";   reactome:R-HSA-5144542 "CLOCK acetylates lysine-15 of histone H3, H4";   reactome:R-HSA-5250938 "B-WICH:histone acetyltransferase acetylates histone H3 at lysine-9"


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histone acetyltransferase activity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G ARRB1 arrestin beta 1 JBrowse link 11 73,624,254 73,670,495 RGD:9068941
G BRCA2 BRCA2 DNA repair associated JBrowse link 13 32,009,039 32,092,463 RGD:9068941
G CLOCK clock circadian regulator JBrowse link 4 74,954,284 75,071,210 RGD:9068941
G CREBBP CREB binding protein JBrowse link 16 3,820,507 3,974,200 RGD:9068941
G EP300 E1A binding protein p300 JBrowse link 22 40,079,214 40,168,936 RGD:9068941
G EPC1 enhancer of polycomb homolog 1 JBrowse link 10 32,985,456 33,095,070 RGD:9068941
G ING3 inhibitor of growth family member 3 JBrowse link 7 125,643,311 125,671,566 RGD:9068941
G KAT14 lysine acetyltransferase 14 JBrowse link 20 18,082,402 18,128,470 RGD:9068941
G KAT2A lysine acetyltransferase 2A JBrowse link 17 15,416,075 15,424,197 RGD:9068941
G KAT2B lysine acetyltransferase 2B JBrowse link 3 20,286,080 20,399,970 RGD:9068941
G KAT5 lysine acetyltransferase 5 JBrowse link 11 64,405,088 64,412,667 RGD:9068941
G KAT6A lysine acetyltransferase 6A JBrowse link 8 38,622,419 38,742,273 RGD:9068941
G KAT6B lysine acetyltransferase 6B JBrowse link 10 74,020,143 74,225,546 RGD:9068941
G KAT7 lysine acetyltransferase 7 JBrowse link 17 48,605,488 48,645,784 RGD:9068941
G KAT8 lysine acetyltransferase 8 JBrowse link 16 31,486,288 31,500,185 RGD:9068941
G MCM3AP minichromosome maintenance complex component 3 associated protein JBrowse link 21 45,828,365 45,878,100 RGD:9068941
G MED24 mediator complex subunit 24 JBrowse link 17 17,456,031 17,489,989 RGD:9068941
G METTL8 methyltransferase like 8 JBrowse link 2B 176,070,609 176,183,862 RGD:9068941
G NCOA3 nuclear receptor coactivator 3 JBrowse link 20 44,919,348 45,073,549 RGD:9068941
G OGA O-GlcNAcase JBrowse link 10 101,858,879 101,892,479 RGD:9068941
G SUPT3H SPT3 homolog, SAGA and STAGA complex component JBrowse link 6 45,687,038 46,239,155 RGD:9068941
G SUPT7L SPT7 like, STAGA complex subunit gamma JBrowse link 2A 27,734,763 27,747,802 RGD:9068941
G TADA2A transcriptional adaptor 2A JBrowse link 17 19,897,659 19,967,926 RGD:9068941
G TADA3 transcriptional adaptor 3 JBrowse link 3 9,969,550 9,982,389 RGD:9068941
G TAF1 TATA-box binding protein associated factor 1 JBrowse link X 70,684,192 70,784,292 RGD:9068941
G TAF10 TATA-box binding protein associated factor 10 JBrowse link 11 6,421,205 6,427,243 RGD:9068941
G TAF12 TATA-box binding protein associated factor 12 JBrowse link 1 28,907,540 28,948,322 RGD:9068941
G TAF5L TATA-box binding protein associated factor 5 like JBrowse link 1 210,168,370 210,200,903 RGD:9068941
G TAF9 TATA-box binding protein associated factor 9 JBrowse link 5 46,201,985 46,207,254 RGD:9068941
H2A histone acetyltransferase activity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G NAA40 N-alpha-acetyltransferase 40, NatD catalytic subunit JBrowse link 11 62,646,077 62,661,595 RGD:9068941
H3 histone acetyltransferase activity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G BRCA2 BRCA2 DNA repair associated JBrowse link 13 32,009,039 32,092,463 RGD:9068941
G KAT2A lysine acetyltransferase 2A JBrowse link 17 15,416,075 15,424,197 RGD:9068941
G MCM3AP minichromosome maintenance complex component 3 associated protein JBrowse link 21 45,828,365 45,878,100 RGD:9068941
H4 histone acetyltransferase activity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G BRCA2 BRCA2 DNA repair associated JBrowse link 13 32,009,039 32,092,463 RGD:9068941
G HAT1 histone acetyltransferase 1 JBrowse link 2B 176,670,029 176,739,120 RGD:9068941
G NAA40 N-alpha-acetyltransferase 40, NatD catalytic subunit JBrowse link 11 62,646,077 62,661,595 RGD:9068941
G NAA50 N-alpha-acetyltransferase 50, NatE catalytic subunit JBrowse link 3 117,781,455 117,808,913 RGD:9068941
G NAA60 N-alpha-acetyltransferase 60, NatF catalytic subunit JBrowse link 16 3,543,418 3,586,299 RGD:9068941
G USP22 ubiquitin specific peptidase 22 JBrowse link 17 35,468,177 35,511,672 RGD:9068941
histone acetyltransferase activity (H3-K23 specific) term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G BRPF1 bromodomain and PHD finger containing 1 JBrowse link 3 9,922,769 9,939,025 RGD:9068941
histone acetyltransferase activity (H4-K12 specific) term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G KAT2A lysine acetyltransferase 2A JBrowse link 17 15,416,075 15,424,197 RGD:9068941
histone acetyltransferase activity (H4-K16 specific) term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G KANSL1 KAT8 regulatory NSL complex subunit 1 JBrowse link 17 11,295,596 11,456,593 RGD:9068941
G KANSL2 KAT8 regulatory NSL complex subunit 2 JBrowse link 12 40,941,614 40,970,079 RGD:9068941
G KANSL3 KAT8 regulatory NSL complex subunit 3 JBrowse link 2A 97,517,112 97,562,253 RGD:9068941
G KAT8 lysine acetyltransferase 8 JBrowse link 16 31,486,288 31,500,185 RGD:9068941
G MCRS1 microspherule protein 1 JBrowse link 12 40,073,860 40,083,655 RGD:9068941
G MSL3 MSL complex subunit 3 JBrowse link X 11,676,301 11,693,474 RGD:9068941
G OGT O-linked N-acetylglucosamine (GlcNAc) transferase JBrowse link X 70,852,687 70,894,921 RGD:9068941
G PHF20 PHD finger protein 20 JBrowse link 20 33,252,044 33,404,375 RGD:9068941
G WDR5 WD repeat domain 5 JBrowse link 9 133,848,185 133,872,889 RGD:9068941
histone acetyltransferase activity (H4-K5 specific) term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G KANSL1 KAT8 regulatory NSL complex subunit 1 JBrowse link 17 11,295,596 11,456,593 RGD:9068941
G KANSL2 KAT8 regulatory NSL complex subunit 2 JBrowse link 12 40,941,614 40,970,079 RGD:9068941
G KANSL3 KAT8 regulatory NSL complex subunit 3 JBrowse link 2A 97,517,112 97,562,253 RGD:9068941
G KAT8 lysine acetyltransferase 8 JBrowse link 16 31,486,288 31,500,185 RGD:9068941
G MCRS1 microspherule protein 1 JBrowse link 12 40,073,860 40,083,655 RGD:9068941
G OGT O-linked N-acetylglucosamine (GlcNAc) transferase JBrowse link X 70,852,687 70,894,921 RGD:9068941
G PHF20 PHD finger protein 20 JBrowse link 20 33,252,044 33,404,375 RGD:9068941
G WDR5 WD repeat domain 5 JBrowse link 9 133,848,185 133,872,889 RGD:9068941
histone acetyltransferase activity (H4-K8 specific) term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G KANSL1 KAT8 regulatory NSL complex subunit 1 JBrowse link 17 11,295,596 11,456,593 RGD:9068941
G KANSL2 KAT8 regulatory NSL complex subunit 2 JBrowse link 12 40,941,614 40,970,079 RGD:9068941
G KANSL3 KAT8 regulatory NSL complex subunit 3 JBrowse link 2A 97,517,112 97,562,253 RGD:9068941
G KAT8 lysine acetyltransferase 8 JBrowse link 16 31,486,288 31,500,185 RGD:9068941
G MCRS1 microspherule protein 1 JBrowse link 12 40,073,860 40,083,655 RGD:9068941
G OGT O-linked N-acetylglucosamine (GlcNAc) transferase JBrowse link X 70,852,687 70,894,921 RGD:9068941
G PHF20 PHD finger protein 20 JBrowse link 20 33,252,044 33,404,375 RGD:9068941
G WDR5 WD repeat domain 5 JBrowse link 9 133,848,185 133,872,889 RGD:9068941

Term paths to the root
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Term Annotations click to browse term
  molecular_function 14776
    catalytic activity 3691
      transferase activity 1625
        transferase activity, transferring acyl groups 202
          transferase activity, transferring acyl groups other than amino-acyl groups 185
            N-acyltransferase activity 88
              N-acetyltransferase activity 63
                peptide N-acetyltransferase activity 49
                  peptide-lysine-N-acetyltransferase activity 45
                    histone acetyltransferase activity 43
                      H2A histone acetyltransferase activity + 1
                      H2B histone acetyltransferase activity + 0
                      H3 histone acetyltransferase activity + 4
                      H4 histone acetyltransferase activity + 16
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.