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ONTOLOGY REPORT - ANNOTATIONS


Term:phenylalanine 4-monooxygenase activity
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Accession:GO:0004505 term browser browse the term
Definition:Catalysis of the reaction: L-phenylalanine + tetrahydrobiopterin + O2 = L-tyrosine + 4-alpha-hydroxytetrahydrobiopterin.
Synonyms:exact_synonym: L-phenylalanine,tetrahydrobiopterin:oxygen oxidoreductase (4-hydroxylating);   PAH activity;   phenylalaninase activity;   phenylalanine 4-hydroxylase activity;   phenylalanine hydroxylase activity
 xref: EC:1.14.16.1;   MetaCyc:PHENYLALANINE-4-MONOOXYGENASE-RXN;   RHEA:20273;   Reactome:R-HSA-5649483 "Defective PAH does not hydroxylate L-Phe to L-Tyr";   reactome:R-HSA-71118 "PAH tetramer hydroxylates L-Phe to L-Tyr"


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phenylalanine 4-monooxygenase activity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G PAH phenylalanine hydroxylase JBrowse link 12 102,836,889 102,958,441 RGD:2290271
G PCBD1 pterin-4 alpha-carbinolamine dehydratase 1 JBrowse link 10 70,882,280 70,888,565 RGD:2290271
G PCBD2 pterin-4 alpha-carbinolamine dehydratase 2 JBrowse link 5 134,905,131 134,962,644 RGD:2290271

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.