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ONTOLOGY REPORT - ANNOTATIONS


Term:endoribonuclease activity
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Accession:GO:0004521 term browser browse the term
Definition:Catalysis of the hydrolysis of ester linkages within ribonucleic acid by creating internal breaks.
Synonyms:related_synonym: endonuclease G activity
 xref: reactome:R-HSA-425923 "IRE1alpha hydrolyzes Xbp1 mRNA and Xbp1 mRNA is spliced";   reactome:R-HSA-426520 "Endonucleolytic RISC hydrolyzes target RNAs";   reactome:R-HSA-5601887 "PLD6 dimer cleaves primary piRNA transcript to pre-piRNA";   reactome:R-HSA-5601910 "Complexed PIWIL2:2'-O-methyl-piRNA cleaves transposon RNA";   reactome:R-HSA-6791223 "18SE pre-rRNA in pre-40S particles is nucleolytically processed during translocation from the nucleus to the cytosol";   reactome:R-HSA-6814555 "Integrator complex processes the 3' end of snRNA";   reactome:R-HSA-9009936 "RNASEL cleaves cellular ssRNA";   reactome:R-HSA-9009941 "RNASEL cleaves viral ssRNA";   reactome:R-HSA-9023909 "C3PO hydrolyzes cleaved passenger strand";   reactome:R-HSA-9023912 "AGO2 cleaves passenger strand of duplex siRNA";   reactome:R-HSA-927836 "SMG6 hydrolyzes mRNA with premature termination codon"


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endoribonuclease activity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G AC118772.1 RGD:13792537
G Ago1 argonaute RISC component 1 JBrowse link 5 144,444,390 144,479,430 RGD:1624291
G Ago2 argonaute RISC catalytic component 2 JBrowse link 7 114,339,607 114,377,277 RGD:1624291
G Ago3 argonaute RISC catalytic component 3 JBrowse link 5 144,355,792 144,436,509 RGD:1624291
G Apex1 apurinic/apyrimidinic endodeoxyribonuclease 1 JBrowse link 15 27,849,943 27,852,083 RGD:2315668
G Cpsf3 cleavage and polyadenylation specific factor 3 JBrowse link 6 43,363,792 43,391,712 RGD:1624291
RGD:13792537
G Dicer1 dicer 1 ribonuclease III JBrowse link 6 128,388,084 128,453,234 RGD:1624291
G Drosha drosha ribonuclease III JBrowse link 2 62,887,267 63,000,307 RGD:1624291
G Endog endonuclease G JBrowse link 3 8,741,833 8,744,414 RGD:13792537
G Endou endonuclease, poly(U)-specific JBrowse link 7 139,202,342 139,223,022 RGD:1624291
RGD:13792537
G Ern1 endoplasmic reticulum to nucleus signaling 1 JBrowse link 10 94,588,555 94,682,072 RGD:1624291
RGD:13792537
G Ern2 endoplasmic reticulum to nucleus signaling 2 JBrowse link 1 192,126,023 192,142,865 RGD:13792537
G Exog exo/endonuclease G JBrowse link 8 128,133,398 128,153,110 RGD:13792537
G Khnyn KH and NYN domain containing JBrowse link 15 34,551,570 34,563,729 RGD:13792537
G Lactb2 lactamase, beta 2 JBrowse link 5 4,982,348 5,005,111 RGD:1624291
RGD:13792537
RGD:1600115
G Nob1 NIN1 (RPN12) binding protein 1 homolog JBrowse link 19 38,397,466 38,409,924 RGD:1624291
RGD:13792537
G Nynrin NYN domain and retroviral integrase containing JBrowse link 15 34,520,040 34,541,671 RGD:13792537
G Piwil1 piwi-like RNA-mediated gene silencing 1 JBrowse link 12 31,608,641 31,629,961 RGD:1624291
G Piwil2 piwi-like RNA-mediated gene silencing 2 JBrowse link 15 52,037,693 52,116,277 RGD:1624291
G Piwil4 piwi-like RNA-mediated gene silencing 4 JBrowse link 8 13,208,774 13,251,970 RGD:1624291
RGD:1600115
G Rcl1 RNA terminal phosphate cyclase-like 1 JBrowse link 1 247,228,012 247,272,369 RGD:13792537
G Rnasek ribonuclease K JBrowse link 10 56,848,367 56,850,085 RGD:1624291
RGD:13792537
G Rnaset2 ribonuclease T2 JBrowse link 1 53,174,879 53,192,048 RGD:13792537
G Slfn13 schlafen family member 13 JBrowse link 10 70,326,157 70,343,024 RGD:13601999
G Slfn14 schlafen family member 14 JBrowse link 10 70,493,340 70,504,810 RGD:1624291
G Smg6 SMG6 nonsense mediated mRNA decay factor JBrowse link 10
10
61,526,024
61,771,912
61,542,583
62,007,030
RGD:1624291
G Snd1 staphylococcal nuclease and tudor domain containing 1 JBrowse link 4 55,772,377 56,171,669 RGD:1624291
RGD:1600115
G Tsn translin JBrowse link 13 34,240,809 34,251,671 RGD:13792537
G Tsnax translin-associated factor X JBrowse link 19 57,771,539 57,785,567 RGD:13792537
G Ybey ybeY metalloendoribonuclease JBrowse link 20 12,917,111 12,926,587 RGD:1624291
G Zc3h12a zinc finger CCCH type containing 12A JBrowse link 5 143,111,342 143,120,131 RGD:1600115
RGD:13792537
RGD:1624291
G Zc3h12b zinc finger CCCH-type containing 12B JBrowse link X 65,040,032 65,074,857 RGD:13792537
G Zc3h12c zinc finger CCCH type containing 12C JBrowse link 8 56,639,439 56,696,968 RGD:13792537
G Zc3h12d zinc finger CCCH type containing 12D JBrowse link 1 1,937,620 1,972,919 RGD:13792537
3'-tRNA processing endoribonuclease activity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Elac1 elaC ribonuclease Z 1 JBrowse link 18 69,706,522 69,723,869 RGD:13792537
G Elac2 elaC ribonuclease Z 2 JBrowse link 10 51,478,378 51,501,167 RGD:13792537
endoribonuclease activity, cleaving miRNA-paired mRNA term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ago2 argonaute RISC catalytic component 2 JBrowse link 7 114,339,607 114,377,277 RGD:1600115
RGD:1624291
G Ago3 argonaute RISC catalytic component 3 JBrowse link 5 144,355,792 144,436,509 RGD:1624291
endoribonuclease activity, cleaving siRNA-paired mRNA term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ago2 argonaute RISC catalytic component 2 JBrowse link 7 114,339,607 114,377,277 RGD:1600115
RGD:1624291
endoribonuclease activity, producing 3'-phosphomonoesters term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Rida reactive intermediate imine deaminase A homolog JBrowse link 7 73,256,506 73,270,308 RGD:9685547
endoribonuclease activity, producing 5'-phosphomonoesters term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Endov endonuclease V JBrowse link 10 108,630,723 108,646,679 RGD:13792537
RGD:1624291
phosphodiesterase decapping endonuclease activity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Edc3 enhancer of mRNA decapping 3 JBrowse link 8 62,482,126 62,527,665 RGD:1624291
G LOC688828 similar to Nucleoside diphosphate-linked moiety X motif 16 (Nudix motif 16) JBrowse link 8 113,687,983 113,689,657 RGD:13792537
G Nudt16 nudix hydrolase 16 JBrowse link 8 113,673,069 113,675,124 RGD:1624291
RGD:13792537
G Nudt16l1 nudix hydrolase 16 like 1 JBrowse link 10 10,829,866 10,831,782 RGD:13792537
ribonuclease A activity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G LOC103690354 ribonuclease pancreatic beta-type JBrowse link 15 28,073,963 28,075,677 RGD:1600115
G LOC103694852 ribonuclease K6-like RGD:1624291
G LOC103694853 ribonuclease pancreatic gamma-type RGD:1600115
G Rnase1 ribonuclease A family member 1, pancreatic RGD:1600115
G Rnase1l1 ribonuclease, RNase A family, 1-like 1 (pancreatic) JBrowse link 15 28,043,491 28,045,098 RGD:1600115
G Rnase1l2 ribonuclease, RNase A family, 1-like 2 (pancreatic) JBrowse link 15 28,127,147 28,128,797 RGD:1600115
ribonuclease III activity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Dgcr8 DGCR8 microprocessor complex subunit JBrowse link 11 86,852,682 86,885,233 RGD:1624291
RGD:13792537
G Dicer1 dicer 1 ribonuclease III JBrowse link 6 128,388,084 128,453,234 RGD:1624291
RGD:13792537
G Drosha drosha ribonuclease III JBrowse link 2 62,887,267 63,000,307 RGD:1624291
RGD:13792537
G Mrpl44 mitochondrial ribosomal protein L44 JBrowse link 9 85,542,763 85,547,814 RGD:13792537
ribonuclease P activity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Pop1 POP1 homolog, ribonuclease P/MRP subunit JBrowse link 7 73,270,403 73,298,209 RGD:1624291
RGD:13792537
G Pop4 POP4 homolog, ribonuclease P/MRP subunit JBrowse link 1 94,661,127 94,669,461 RGD:1624291
RGD:13792537
RGD:1600115
G Pop5 POP5 homolog, ribonuclease P/MRP subunit JBrowse link 12 47,138,346 47,143,152 RGD:1624291
RGD:13792537
G Pop7 POP7 homolog, ribonuclease P/MRP subunit JBrowse link 12 22,259,713 22,260,754 RGD:13792537
RGD:1624291
G Prorp protein only RNase P catalytic subunit JBrowse link 6 76,079,880 76,171,298 RGD:1600115
RGD:13792537
RGD:1624291
G Rpp14 ribonuclease P/MRP subunit p14 JBrowse link 15 18,625,963 18,636,157 RGD:1624291
G Rpp21 ribonuclease P/MRP subunit p21 JBrowse link 20 2,515,541 2,517,471 RGD:1624291
RGD:13792537
G Rpp25 ribonuclease P and MRP subunit p25 JBrowse link 8 62,283,336 62,284,716 RGD:1624291
RGD:1600115
G Rpp30 ribonuclease P/MRP subunit p30 JBrowse link 1 254,697,247 254,720,093 RGD:1624291
RGD:13792537
G Rpp38 ribonuclease P/MRP subunit p38 JBrowse link 17 78,915,450 78,919,144 RGD:1624291
RGD:13792537
G Rpp40 ribonuclease P/MRP subunit p40 JBrowse link 17 29,638,647 29,647,709 RGD:1624291
RGD:13792537
ribonuclease T2 activity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Rnaset2 ribonuclease T2 JBrowse link 1 53,174,879 53,192,048 RGD:1600115
RNA lariat debranching enzyme activity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Dbr1 debranching RNA lariats 1 JBrowse link 8 107,826,690 107,838,186 RGD:1624291
RGD:13792537
RNA-DNA hybrid ribonuclease activity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Fen1 flap structure-specific endonuclease 1 JBrowse link 1 226,251,516 226,256,160 RGD:1624291
RGD:13792537
G Rnaseh1 ribonuclease H1 JBrowse link 6 47,916,188 47,925,582 RGD:1624291
RGD:13792537
RGD:1600115
G Rnaseh2a ribonuclease H2, subunit A JBrowse link 19 26,074,980 26,084,780 RGD:1624291
RGD:13792537
RGD:1600115
G Rnaseh2b ribonuclease H2, subunit B JBrowse link 15 45,422,010 45,472,792 RGD:1624291
RGD:13792537
tRNA-intron endonuclease activity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Tsen2 tRNA splicing endonuclease subunit 2 JBrowse link 4 147,455,506 147,490,869 RGD:13792537
G Tsen34 tRNA splicing endonuclease subunit 34 JBrowse link 1 64,023,924 64,031,756 RGD:13792537
G Tsen34l1 tRNA splicing endonuclease subunit 34-like 1 JBrowse link 1 64,092,224 64,100,061 RGD:13792537

Term paths to the root
Path 1
Term Annotations click to browse term
  molecular_function 20216
    catalytic activity 6044
      catalytic activity, acting on RNA 355
        ribonuclease activity 127
          endoribonuclease activity 69
            endoribonuclease activity involved in viral induction of host mRNA catabolic process 0
            endoribonuclease activity, producing 3'-phosphomonoesters + 11
            endoribonuclease activity, producing 5'-phosphomonoesters + 29
Path 2
Term Annotations click to browse term
  molecular_function 20216
    catalytic activity 6044
      hydrolase activity 2624
        hydrolase activity, acting on ester bonds 800
          nuclease activity 220
            endonuclease activity 126
              endoribonuclease activity 69
                endoribonuclease activity involved in viral induction of host mRNA catabolic process 0
                endoribonuclease activity, producing 3'-phosphomonoesters + 11
                endoribonuclease activity, producing 5'-phosphomonoesters + 29
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.