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ONTOLOGY REPORT - ANNOTATIONS


Term:endoribonuclease activity
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Accession:GO:0004521 term browser browse the term
Definition:Catalysis of the hydrolysis of ester linkages within ribonucleic acid by creating internal breaks.
Synonyms:related_synonym: endonuclease G activity
 xref: reactome:R-HSA-425923 "IRE1alpha hydrolyzes Xbp1 mRNA and Xbp1 mRNA is spliced";   reactome:R-HSA-426520 "Endonucleolytic RISC hydrolyzes target RNAs";   reactome:R-HSA-5601887 "PLD6 dimer cleaves primary piRNA transcript to pre-piRNA";   reactome:R-HSA-5601910 "Complexed PIWIL2:2'-O-methyl-piRNA cleaves transposon RNA";   reactome:R-HSA-6791223 "18SE pre-rRNA in pre-40S particles is nucleolytically processed during translocation from the nucleus to the cytosol";   reactome:R-HSA-6814555 "Integrator complex processes the 3' end of snRNA";   reactome:R-HSA-9009936 "RNASEL cleaves cellular ssRNA";   reactome:R-HSA-9009941 "RNASEL cleaves viral ssRNA";   reactome:R-HSA-9023909 "C3PO hydrolyzes cleaved passenger strand";   reactome:R-HSA-9023912 "AGO2 cleaves passenger strand of duplex siRNA";   reactome:R-HSA-927836 "SMG6 hydrolyzes mRNA with premature termination codon"


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endoribonuclease activity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G AGO1 argonaute RISC component 1 JBrowse link 1 36,324,733 36,370,798 RGD:9068941
G AGO2 argonaute RISC catalytic component 2 JBrowse link 8 140,278,610 140,361,124 RGD:9068941
G APEX1 apurinic/apyrimidinic endodeoxyribonuclease 1 JBrowse link 14 19,381,911 19,384,542 RGD:9068941
G CPSF3 cleavage and polyadenylation specific factor 3 JBrowse link 2A 9,576,871 9,626,202 RGD:9068941
G DICER1 dicer 1, ribonuclease III JBrowse link 14 95,036,385 95,107,940 RGD:9068941
G DROSHA drosha ribonuclease III JBrowse link 5 84,191,596 84,322,590 RGD:9068941
G ENDOU endonuclease, poly(U) specific JBrowse link 12 41,882,397 41,898,189 RGD:9068941
G ERN1 endoplasmic reticulum to nucleus signaling 1 JBrowse link 17 63,226,949 63,317,825 RGD:9068941
G LACTB2 lactamase beta 2 JBrowse link 8 68,823,061 68,854,992 RGD:9068941
G LOC100968913 argonaute RISC catalytic component 3 JBrowse link 1 36,371,926 36,497,190 RGD:9068941
G NOB1 NIN1 (RPN12) binding protein 1 homolog JBrowse link 16 69,506,425 69,517,932 RGD:9068941
G PIWIL1 piwi like RNA-mediated gene silencing 1 JBrowse link 12 132,169,820 132,199,374 RGD:9068941
G PIWIL2 piwi like RNA-mediated gene silencing 2 JBrowse link 8 18,459,052 18,546,688 RGD:9068941
G PIWIL4 piwi like RNA-mediated gene silencing 4 JBrowse link 11 93,098,926 93,151,404 RGD:9068941
G RNASEK ribonuclease K JBrowse link 17 7,031,283 7,033,393 RGD:9068941
G SLFN11 schlafen family member 11 JBrowse link 17 21,705,803 21,728,810 RGD:9068941
G SLFN13 schlafen family member 13 JBrowse link 17 21,638,342 21,647,766 RGD:9068941
G SLFN14 schlafen family member 14 JBrowse link 17 21,530,009 21,539,589 RGD:9068941
G SMG6 SMG6 nonsense mediated mRNA decay factor JBrowse link 17 1,937,630 2,179,535 RGD:9068941
G SND1 staphylococcal nuclease and tudor domain containing 1 JBrowse link 7 132,302,137 132,738,223 RGD:9068941
G YBEY ybeY metalloendoribonuclease JBrowse link 21 45,879,517 45,888,717 RGD:9068941
G ZC3H12A zinc finger CCCH-type containing 12A JBrowse link 1 38,093,036 38,103,556 RGD:9068941
endoribonuclease activity, cleaving miRNA-paired mRNA term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G AGO2 argonaute RISC catalytic component 2 JBrowse link 8 140,278,610 140,361,124 RGD:9068941
G LOC100968913 argonaute RISC catalytic component 3 JBrowse link 1 36,371,926 36,497,190 RGD:9068941
endoribonuclease activity, cleaving siRNA-paired mRNA term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G AGO2 argonaute RISC catalytic component 2 JBrowse link 8 140,278,610 140,361,124 RGD:9068941
endoribonuclease activity, producing 3'-phosphomonoesters term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G RIDA reactive intermediate imine deaminase A homolog JBrowse link 8 96,923,776 96,938,512 RGD:9068941
endoribonuclease activity, producing 5'-phosphomonoesters term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G ENDOV endonuclease V JBrowse link 17 80,576,451 80,591,856 RGD:9068941
phosphodiesterase decapping endonuclease activity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G EDC3 enhancer of mRNA decapping 3 JBrowse link 15 73,196,823 73,262,222 RGD:9068941
G NUDT16 nudix hydrolase 16 JBrowse link 3 135,788,354 135,795,417 RGD:9068941
ribonuclease III activity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G DGCR8 DGCR8 microprocessor complex subunit JBrowse link 22 18,518,789 18,544,740 RGD:9068941
G DICER1 dicer 1, ribonuclease III JBrowse link 14 95,036,385 95,107,940 RGD:9068941
G DROSHA drosha ribonuclease III JBrowse link 5 84,191,596 84,322,590 RGD:9068941
ribonuclease P activity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G POP1 POP1 homolog, ribonuclease P/MRP subunit JBrowse link 8 96,938,574 96,980,896 RGD:9068941
G POP4 POP4 homolog, ribonuclease P/MRP subunit JBrowse link 19 35,296,084 35,307,008 RGD:9068941
G POP5 POP5 homolog, ribonuclease P/MRP subunit JBrowse link 12 121,535,005 121,537,350 RGD:9068941
G POP7 POP7 homolog, ribonuclease P/MRP subunit JBrowse link 7 106,124,018 106,135,430 RGD:9068941
G PRORP protein only RNase P catalytic subunit JBrowse link 14 34,056,234 34,209,657 RGD:9068941
G RPP14 ribonuclease P/MRP subunit p14 JBrowse link 3 59,653,220 59,666,531 RGD:9068941
G RPP21 ribonuclease P/MRP subunit p21 JBrowse link 6 30,994,039 30,995,764 RGD:9068941
G RPP25 ribonuclease P and MRP subunit p25 RGD:9068941
G RPP30 ribonuclease P/MRP subunit p30 JBrowse link 10 91,138,993 91,171,848 RGD:9068941
G RPP38 ribonuclease P/MRP subunit p38 JBrowse link 10 15,694,410 15,701,569 RGD:9068941
G RPP40 ribonuclease P/MRP subunit p40 JBrowse link 6 5,015,953 5,024,540 RGD:9068941
RNA lariat debranching enzyme activity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G DBR1 debranching RNA lariats 1 JBrowse link 3 142,639,712 142,653,016 RGD:9068941
RNA-DNA hybrid ribonuclease activity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G FEN1 flap structure-specific endonuclease 1 JBrowse link 11 60,452,750 60,457,354 RGD:9068941
G RNASEH1 ribonuclease H1 JBrowse link 2A 3,482,772 3,496,978 RGD:9068941
G RNASEH2A ribonuclease H2 subunit A JBrowse link 19 13,112,242 13,119,514 RGD:9068941
G RNASEH2B ribonuclease H2 subunit B JBrowse link 13 50,804,013 50,839,440 RGD:9068941

Term paths to the root
Path 1
Term Annotations click to browse term
  molecular_function 14776
    catalytic activity 3691
      catalytic activity, acting on RNA 217
        ribonuclease activity 86
          endoribonuclease activity 43
            endoribonuclease activity involved in viral induction of host mRNA catabolic process 0
            endoribonuclease activity, producing 3'-phosphomonoesters + 1
            endoribonuclease activity, producing 5'-phosphomonoesters + 24
Path 2
Term Annotations click to browse term
  molecular_function 14776
    catalytic activity 3691
      hydrolase activity 1410
        hydrolase activity, acting on ester bonds 534
          nuclease activity 151
            endonuclease activity 80
              endoribonuclease activity 43
                endoribonuclease activity involved in viral induction of host mRNA catabolic process 0
                endoribonuclease activity, producing 3'-phosphomonoesters + 1
                endoribonuclease activity, producing 5'-phosphomonoesters + 24
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.