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ONTOLOGY REPORT - ANNOTATIONS


Term:endoribonuclease activity
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Accession:GO:0004521 term browser browse the term
Definition:Catalysis of the hydrolysis of ester linkages within ribonucleic acid by creating internal breaks.
Synonyms:related_synonym: endonuclease G activity
 xref: reactome:R-HSA-425923 "IRE1alpha hydrolyzes Xbp1 mRNA and Xbp1 mRNA is spliced";   reactome:R-HSA-426520 "Endonucleolytic RISC hydrolyzes target RNAs";   reactome:R-HSA-5601887 "PLD6 dimer cleaves primary piRNA transcript to pre-piRNA";   reactome:R-HSA-5601910 "Complexed PIWIL2:2'-O-methyl-piRNA cleaves transposon RNA";   reactome:R-HSA-6791223 "18SE pre-rRNA in pre-40S particles is nucleolytically processed during translocation from the nucleus to the cytosol";   reactome:R-HSA-6814555 "Integrator complex processes the 3' end of snRNA";   reactome:R-HSA-9009936 "RNASEL cleaves cellular ssRNA";   reactome:R-HSA-9009941 "RNASEL cleaves viral ssRNA";   reactome:R-HSA-9023909 "C3PO hydrolyzes cleaved passenger strand";   reactome:R-HSA-9023912 "AGO2 cleaves passenger strand of duplex siRNA";   reactome:R-HSA-927836 "SMG6 hydrolyzes mRNA with premature termination codon"


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endoribonuclease activity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ago2 argonaute RISC catalytic component 2 JBrowse link NW_004936470 10,641,109 10,690,587 RGD:9068941
G Apex1 apurinic/apyrimidinic endodeoxyribonuclease 1 JBrowse link NW_004936877 666,545 669,351 RGD:9068941
G Cpsf3 cleavage and polyadenylation specific factor 3 JBrowse link NW_004936532 5,814,331 5,850,188 RGD:9068941
G Dicer1 dicer 1, ribonuclease III JBrowse link NW_004936846 528,768 584,599 RGD:9068941
G Drosha drosha ribonuclease III JBrowse link NW_004936518 9,100,094 9,218,405 RGD:9068941
G Endou endonuclease, poly(U) specific JBrowse link NW_004936512 5,607,657 5,627,513 RGD:9068941
G Ern1 endoplasmic reticulum to nucleus signaling 1 JBrowse link NW_004936541 4,613,197 4,705,911 RGD:9068941
G Lactb2 lactamase beta 2 JBrowse link NW_004936496 15,292,216 15,319,800 RGD:9068941
G Nob1 NIN1 (RPN12) binding protein 1 homolog JBrowse link NW_004936475 19,794,199 19,808,142 RGD:9068941
G Piwil1 piwi like RNA-mediated gene silencing 1 JBrowse link NW_004936660 1,398,640 1,418,865 RGD:9068941
G Piwil2 piwi like RNA-mediated gene silencing 2 JBrowse link NW_004936555 6,078,681 6,133,184 RGD:9068941
G Piwil4 piwi like RNA-mediated gene silencing 4 JBrowse link NW_004936674 355,302 402,388 RGD:9068941
G Rnasek ribonuclease K JBrowse link NW_004936595 284,313 286,167 RGD:9068941
G Smg6 SMG6 nonsense mediated mRNA decay factor JBrowse link NW_004936538 8,126,307 8,361,920 RGD:9068941
G Snd1 staphylococcal nuclease and tudor domain containing 1 JBrowse link NW_004936479 14,848,438 15,259,735 RGD:9068941
G Ybey ybeY metalloendoribonuclease JBrowse link NW_004936778 265,855 273,053 RGD:9068941
G Zc3h12a zinc finger CCCH-type containing 12A JBrowse link NW_004936474 19,714,145 19,722,512 RGD:9068941
endoribonuclease activity, cleaving miRNA-paired mRNA term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ago2 argonaute RISC catalytic component 2 JBrowse link NW_004936470 10,641,109 10,690,587 RGD:9068941
endoribonuclease activity, cleaving siRNA-paired mRNA term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ago2 argonaute RISC catalytic component 2 JBrowse link NW_004936470 10,641,109 10,690,587 RGD:9068941
endoribonuclease activity, producing 3'-phosphomonoesters term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Rida reactive intermediate imine deaminase A homolog JBrowse link NW_004936470 44,710,481 44,721,159 RGD:9068941
endoribonuclease activity, producing 5'-phosphomonoesters term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Endov endonuclease V JBrowse link NW_004936594 4,332,225 4,345,743 RGD:9068941
phosphodiesterase decapping endonuclease activity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Edc3 enhancer of mRNA decapping 3 JBrowse link NW_004936471 33,617,256 33,667,371 RGD:9068941
G LOC101965734 U8 snoRNA-decapping enzyme JBrowse link NW_004936529 4,825,277 4,827,011 RGD:9068941
ribonuclease III activity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Dgcr8 DGCR8 microprocessor complex subunit JBrowse link NW_004936619 3,977,307 4,014,490 RGD:9068941
G Dicer1 dicer 1, ribonuclease III JBrowse link NW_004936846 528,768 584,599 RGD:9068941
G Drosha drosha ribonuclease III JBrowse link NW_004936518 9,100,094 9,218,405 RGD:9068941
ribonuclease P activity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Pop1 POP1 homolog, ribonuclease P/MRP subunit JBrowse link NW_004936470 44,676,798 44,710,397 RGD:9068941
G Pop4 POP4 homolog, ribonuclease P/MRP subunit JBrowse link NW_004936570 5,704,692 5,714,666 RGD:9068941
G Pop5 POP5 homolog, ribonuclease P/MRP subunit JBrowse link NW_004936668 385,945 388,688 RGD:9068941
G Pop7 POP7 homolog, ribonuclease P/MRP subunit JBrowse link NW_004936543 725,338 732,707 RGD:9068941
G Prorp protein only RNase P catalytic subunit JBrowse link NW_004936494 9,282,894 9,414,350 RGD:9068941
G Rpp14 ribonuclease P/MRP subunit p14 JBrowse link NW_004936473 2,670,918 2,678,629 RGD:9068941
G Rpp21 ribonuclease P/MRP subunit p21 JBrowse link NW_004936837 105,369 107,747 RGD:9068941
G Rpp25 ribonuclease P and MRP subunit p25 JBrowse link NW_004936471 33,903,275 33,905,766 RGD:9068941
G Rpp30 ribonuclease P/MRP subunit p30 JBrowse link NW_004936601 3,520,066 3,549,189 RGD:9068941
G Rpp38 ribonuclease P/MRP subunit p38 JBrowse link NW_004936574 5,648,696 5,653,030 RGD:9068941
G Rpp40 ribonuclease P/MRP subunit p40 JBrowse link NW_004936534 7,471,209 7,480,457 RGD:9068941
RNA lariat debranching enzyme activity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Dbr1 debranching RNA lariats 1 JBrowse link NW_004936540 504,638 515,913 RGD:9068941
RNA-DNA hybrid ribonuclease activity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Fen1 flap structure-specific endonuclease 1 JBrowse link NW_004936581 1,328,685 1,332,713 RGD:9068941
G Rnaseh1 ribonuclease H1 JBrowse link NW_004936532 1,700,414 1,714,689 RGD:9068941
G Rnaseh2a ribonuclease H2 subunit A JBrowse link NW_004936659 1,897,777 1,905,526 RGD:9068941
G Rnaseh2b ribonuclease H2 subunit B JBrowse link NW_004936565 3,791,305 3,839,991 RGD:9068941

Term paths to the root
Path 1
Term Annotations click to browse term
  molecular_function 13925
    catalytic activity 3545
      catalytic activity, acting on RNA 207
        ribonuclease activity 78
          endoribonuclease activity 38
            endoribonuclease activity involved in viral induction of host mRNA catabolic process 0
            endoribonuclease activity, producing 3'-phosphomonoesters + 1
            endoribonuclease activity, producing 5'-phosphomonoesters + 23
Path 2
Term Annotations click to browse term
  molecular_function 13925
    catalytic activity 3545
      hydrolase activity 1362
        hydrolase activity, acting on ester bonds 517
          nuclease activity 142
            endonuclease activity 75
              endoribonuclease activity 38
                endoribonuclease activity involved in viral induction of host mRNA catabolic process 0
                endoribonuclease activity, producing 3'-phosphomonoesters + 1
                endoribonuclease activity, producing 5'-phosphomonoesters + 23
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.