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ONTOLOGY REPORT - ANNOTATIONS


Term:phosphodiesterase I activity
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Accession:GO:0004528 term browser browse the term
Definition:Catalysis of the sequential hydrolytic removal of 5'-nucleotides from the 3'-hydroxy termini of 3'-hydroxy-terminated oligonucleotides.
Synonyms:broad_synonym: phosphodiesterase activity
 related_synonym: 5' nucleotide phosphodiesterase/alkaline phosphodiesterase I activity;   5'-NPDase activity;   5'-PDE activity;   5'-PDase activity;   5'-exonuclease activity;   5'-nucleotide phosphodiesterase activity;   5'-phosphodiesterase activity;   5'NPDE activity;   PDE I activity;   alkaline phosphodiesterase activity;   exonuclease I activity;   nucleotide pyrophosphatase/phosphodiesterase I activity;   oligonucleate 5'-nucleotidohydrolase activity;   orthophosphoric diester phosphohydrolase activity
 xref: EC:3.1.4.1;   MetaCyc:3.1.4.1-RXN


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phosphodiesterase I activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Apex1 apurinic/apyrimidinic endodeoxyribonuclease 1 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr15:27,849,943...27,852,083
Ensembl chr15:27,849,979...27,852,082
JBrowse link
G Apex2 apurinic/apyrimidinic endodeoxyribonuclease 2 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr  X:23,146,085...23,166,676
Ensembl chr  X:23,146,085...23,166,675
JBrowse link
G Enpp1 ectonucleotide pyrophosphatase/phosphodiesterase 1 IDA
ISO
IEA
IBA
ISS
(MGI:67562|PMID:1647027)
GO_REF:0000107
PMID:21873635
GO_REF:0000024
(PMID:27467858)
RGD
Ensembl
UniProt
PMID:1647027, PMID:27467858, PMID:17187902, PMID:21873635 GO_REF:0000024, GO_REF:0000107, MGI:67562, RGD:13204714, RGD:13792537 NCBI chr 1:21,748,201...21,813,205
Ensembl chr 1:21,748,261...21,813,371
JBrowse link
G Enpp2 ectonucleotide pyrophosphatase/phosphodiesterase 2 IMP
IEA
IBA
GO_REF:0000002
PMID:21873635
InterPro PMID:17307740, PMID:21873635 GO_REF:0000002, RGD:9685416, RGD:13792537 NCBI chr 7:94,479,931...94,563,086
Ensembl chr 7:94,480,396...94,563,001
JBrowse link
G Enpp3 ectonucleotide pyrophosphatase/phosphodiesterase 3 TAS
ISS
ISO
GO_REF:0000024
(PMID:11342463)
UniProt
RGD
PMID:11342463, PMID:9096610 GO_REF:0000024, RGD:1299489 NCBI chr 1:21,613,148...21,684,483
Ensembl chr 1:21,613,148...21,684,480
JBrowse link
G Fan1 FANCD2 and FANCI associated nuclease 1 IEA GO_REF:0000003 UniProt GO_REF:0000003 NCBI chr 1:125,182,117...125,209,772
Ensembl chr 1:125,181,838...125,209,727
JBrowse link

Term paths to the root
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Term Annotations click to browse term
  molecular_function 20457
    catalytic activity 6065
      hydrolase activity 2637
        hydrolase activity, acting on ester bonds 804
          phosphoric ester hydrolase activity 377
            phosphoric diester hydrolase activity 90
              phosphodiesterase I activity 6
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.