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Term:lysophospholipase activity
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Accession:GO:0004622 term browser browse the term
Definition:Catalysis of the reaction: 2-lysophosphatidylcholine + H2O = glycerophosphocholine + a carboxylate.
Synonyms:exact_synonym: 2-lysophosphatidylcholine acylhydrolase activity;   lecithinase B activity;   lecitholipase activity;   lysolecithinase activity;   lysophosphatidase activity;   lysophosphatidylcholine hydrolase activity;   phospholipase B activity
 related_synonym: lysophopholipase L2;   lysophospholipase A1;   phosphatidase B
 alt_id: GO:0045126
 xref: EC:;   MetaCyc:LYSOPHOSPHOLIPASE-RXN;   RHEA:15177;   reactome:R-HSA-1482545 "2-acyl LPE is hydrolyzed to GPETA by PLA2G4C";   reactome:R-HSA-1482571 "1-acyl LPE is hydrolyzed to GPETA by PLA2G4C";   reactome:R-HSA-1482612 "2-acyl LPC is hydrolyzed to GPCho by PLA2[8]";   reactome:R-HSA-1482629 "2-acyl LPC is hydrolyzed to GPCho by PLA2G4C";   reactome:R-HSA-1482685 "1-acyl LPC is hydrolyzed to GPCho by PLA2[8]";   reactome:R-HSA-1482696 "1-acyl LPC is hydrolyzed to GPCho by PLA2G4C";   reactome:R-HSA-6814254 "PNPLA6 hydrolyzes LysoPtdCho";   reactome:R-HSA-6814766 "GDPD1 hydrolyzes LysoPtdCho";   reactome:R-HSA-6814778 "GDPD3 hydrolyzes LysoPtdCho";   reactome:R-HSA-8847912 "PNPLA7 hydrolyzes LysoPtdCho"

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lysophospholipase activity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Abhd12 abhydrolase domain containing 12, lysophospholipase JBrowse link NW_004955415 31,284,947 31,337,703 RGD:9068941
G Abhd12b abhydrolase domain containing 12B JBrowse link NW_004955409 12,007,471 12,036,999 RGD:9068941
G Abhd16a abhydrolase domain containing 16A, phospholipase JBrowse link NW_004955437 227,407 241,702 RGD:9068941
G Abhd4 abhydrolase domain containing 4, N-acyl phospholipase B JBrowse link NW_004955409 37,650,220 37,662,950 RGD:9068941
G Aspg asparaginase JBrowse link NW_004955538 2,765,215 2,785,390 RGD:9068941
G Enpp2 ectonucleotide pyrophosphatase/phosphodiesterase 2 JBrowse link NW_004955417 25,308,424 25,384,307 RGD:9068941
G Gde1 glycerophosphodiester phosphodiesterase 1 JBrowse link NW_004955442 3,186,440 3,219,092 RGD:9068941
G Gdpd1 glycerophosphodiester phosphodiesterase domain containing 1 JBrowse link NW_004955451 3,751,229 3,799,651 RGD:9068941
G Gdpd3 glycerophosphodiester phosphodiesterase domain containing 3 JBrowse link NW_004955493 6,876,943 6,883,716 RGD:9068941
G Lipc lipase C, hepatic type JBrowse link NW_004955450 15,947,869 16,062,449 RGD:9068941
G Lypla1 lysophospholipase 1 JBrowse link NW_004955454 13,356,851 13,385,110 RGD:9068941
G Lypla2 lysophospholipase 2 JBrowse link NW_004955452 3,710,818 3,715,047 RGD:9068941
G Lyplal1 lysophospholipase like 1 JBrowse link NW_004955520 4,251,863 4,281,775 RGD:9068941
G Mgll monoglyceride lipase JBrowse link NW_004955429 15,760,159 15,960,774 RGD:9068941
G Pla2g15 phospholipase A2 group XV JBrowse link NW_004955484 8,386,274 8,412,952 RGD:9068941
G Pla2g4a phospholipase A2 group IVA JBrowse link NW_004955406 25,257,361 25,392,079 RGD:9068941
G Pla2g4b phospholipase A2 group IVB JBrowse link NW_004955416 8,633,249 8,643,219 RGD:9068941
G Pla2g4c phospholipase A2 group IVC JBrowse link NW_004955609 182,706 212,102 RGD:9068941
G Pla2g4f phospholipase A2 group IVF JBrowse link NW_004955416 8,876,560 8,889,764 RGD:9068941
G Pla2g6 phospholipase A2 group VI JBrowse link NW_004955413 24,431,592 24,482,229 RGD:9068941
G Plb1 phospholipase B1 JBrowse link NW_004955469 10,370,646 10,511,263 RGD:9068941
G Pnpla6 patatin like phospholipase domain containing 6 JBrowse link NW_004955563 1,681,112 1,703,287 RGD:9068941
G Pnpla7 patatin like phospholipase domain containing 7 JBrowse link NW_004955513 5,376,690 5,436,095 RGD:9068941
G Pnpla8 patatin like phospholipase domain containing 8 JBrowse link NW_004955410 12,715,072 12,753,433 RGD:9068941

Term paths to the root
Path 1
Term Annotations click to browse term
  molecular_function 14704
    catalytic activity 5182
      hydrolase activity 2258
        hydrolase activity, acting on ester bonds 711
          carboxylic ester hydrolase activity 124
            lysophospholipase activity 24
Path 2
Term Annotations click to browse term
  molecular_function 14704
    catalytic activity 5182
      hydrolase activity 2258
        hydrolase activity, acting on ester bonds 711
          lipase activity 121
            phospholipase activity 101
              lysophospholipase activity 24
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.