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ONTOLOGY REPORT - ANNOTATIONS


Term:lysophospholipase activity
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Accession:GO:0004622 term browser browse the term
Definition:Catalysis of the reaction: 2-lysophosphatidylcholine + H2O = glycerophosphocholine + a carboxylate.
Synonyms:exact_synonym: 2-lysophosphatidylcholine acylhydrolase activity;   lecithinase B activity;   lecitholipase activity;   lysolecithinase activity;   lysophosphatidase activity;   lysophosphatidylcholine hydrolase activity;   phospholipase B activity
 related_synonym: lysophopholipase L2;   lysophospholipase A1;   phosphatidase B
 alt_id: GO:0045126
 xref: EC:3.1.1.5;   MetaCyc:LYSOPHOSPHOLIPASE-RXN;   RHEA:15177;   reactome:R-HSA-1482545 "2-acyl LPE is hydrolyzed to GPETA by PLA2G4C";   reactome:R-HSA-1482571 "1-acyl LPE is hydrolyzed to GPETA by PLA2G4C";   reactome:R-HSA-1482612 "2-acyl LPC is hydrolyzed to GPCho by PLA2[8]";   reactome:R-HSA-1482629 "2-acyl LPC is hydrolyzed to GPCho by PLA2G4C";   reactome:R-HSA-1482685 "1-acyl LPC is hydrolyzed to GPCho by PLA2[8]";   reactome:R-HSA-1482696 "1-acyl LPC is hydrolyzed to GPCho by PLA2G4C";   reactome:R-HSA-6814254 "PNPLA6 hydrolyzes LysoPtdCho";   reactome:R-HSA-6814766 "GDPD1 hydrolyzes LysoPtdCho";   reactome:R-HSA-6814778 "GDPD3 hydrolyzes LysoPtdCho";   reactome:R-HSA-8847912 "PNPLA7 hydrolyzes LysoPtdCho"


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lysophospholipase activity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Abhd12 abhydrolase domain containing 12 JBrowse link 2 150,832,493 150,904,779 RGD:2290270
G Abhd12b abhydrolase domain containing 12B JBrowse link 12 70,154,124 70,190,096 RGD:2290270
G Abhd4 abhydrolase domain containing 4 JBrowse link 14 54,254,129 54,269,169 RGD:2290270
G Alkbh5 alkB homolog 5, RNA demethylase JBrowse link 11 60,537,683 60,558,512 RGD:2290270
G Aspg asparaginase JBrowse link 12 112,106,683 112,127,573 RGD:2290270
G Cel carboxyl ester lipase JBrowse link 2 28,555,819 28,563,403 RGD:2290270
G Enpp2 ectonucleotide pyrophosphatase/phosphodiesterase 2 JBrowse link 15 54,838,901 54,952,789 RGD:2290270
G Gde1 glycerophosphodiester phosphodiesterase 1 JBrowse link 7 118,688,558 118,705,738 RGD:2290270
G Gdpd1 glycerophosphodiester phosphodiesterase domain containing 1 JBrowse link 11 87,033,794 87,074,137 RGD:2290270
G Gdpd3 glycerophosphodiester phosphodiesterase domain containing 3 JBrowse link 7 126,766,414 126,775,645 RGD:2290270
G Lipc lipase, hepatic JBrowse link 9 70,798,128 70,952,221 RGD:2290270
G Lypla1 lysophospholipase 1 JBrowse link 1 4,807,823 4,846,735 RGD:2290270
G Lypla2 lysophospholipase 2 JBrowse link 4 135,968,224 135,972,612 RGD:2290270
G Pla2g15 phospholipase A2, group XV JBrowse link 8 106,150,354 106,164,718 RGD:2290270
G Pla2g4a phospholipase A2, group IVA (cytosolic, calcium-dependent) JBrowse link 1 149,829,618 149,961,290 RGD:2290270
G Pla2g4b phospholipase A2, group IVB (cytosolic) JBrowse link 2 120,033,433 120,043,033 RGD:2290270
G Pla2g4f phospholipase A2, group IVF JBrowse link 2 120,299,952 120,314,165 RGD:2290270
G Pla2g6 phospholipase A2, group VI JBrowse link 15 79,286,228 79,328,385 RGD:2290270
G Plb1 phospholipase B1 JBrowse link 5 32,232,691 32,364,356 RGD:2290270
G Pnpla6 patatin-like phospholipase domain containing 6 JBrowse link 8 3,515,235 3,544,267 RGD:2290270
G Pnpla7 patatin-like phospholipase domain containing 7 JBrowse link 2 24,975,990 25,054,072 RGD:2290270
G Pnpla8 patatin-like phospholipase domain containing 8 JBrowse link 12 44,269,132 44,315,936 RGD:2290270

Term paths to the root
Path 1
Term Annotations click to browse term
  molecular_function 22376
    catalytic activity 5700
      hydrolase activity 2473
        hydrolase activity, acting on ester bonds 761
          carboxylic ester hydrolase activity 164
            lysophospholipase activity 22
Path 2
Term Annotations click to browse term
  molecular_function 22376
    catalytic activity 5700
      hydrolase activity 2473
        hydrolase activity, acting on ester bonds 761
          lipase activity 123
            phospholipase activity 91
              lysophospholipase activity 22
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.